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Nutraceuticals: potential for chondroprotection and molecular targeting of osteoarthritis.

Abstract

Osteoarthritis (OA) is a degenerative joint disease and a leading cause of adult disability. There is no cure for OA, and no effective treatments which arrest or slow its progression. Current pharmacologic treatments such as analgesics may improve pain relief but do not alter OA disease progression. Prolonged consumption of these drugs can result in severe adverse effects. Given the nature of OA, life-long treatment will likely be required to arrest or slow its progression. Consequently, there is an urgent need for OA disease-modifying therapies which also improve symptoms and are safe for clinical use over long periods of time. Nutraceuticals-food or food products that provide medical or health benefits, including the prevention and/or treatment of a disease-offer not only favorable safety profiles, but may exert disease- and symptom-modification effects in OA. Forty-seven percent of OA patients use alternative medications, including nutraceuticals. This review will overview the efficacy and mechanism of action of commonly used nutraceuticals, discuss recent experimental and clinical data on the effects of select nutraceuticals, such as phytoflavonoids, polyphenols, and bioflavonoids on OA, and highlight their known molecular actions and limitations of their current use. We will conclude with a proposed novel nutraceutical-based molecular targeting strategy for chondroprotection and OA treatment.

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  • Authors+Show Affiliations

    ,

    Department of Orthopaedic Surgery, Albert Einstein College of Medicine and Montefiore Medical Center, Bronx, NY 10461, USA. herb.sun@einstein.yu.edu.

    , , , ,

    Source

    International journal of molecular sciences 14:11 2013 Nov 21 pg 23063-85

    MeSH

    Dietary Supplements
    Flavonoids
    Ginger
    Humans
    Molecular Targeted Therapy
    Osteoarthritis
    Oxidative Stress
    Polyphenols
    Punicaceae
    Tea

    Pub Type(s)

    Journal Article
    Review

    Language

    eng

    PubMed ID

    24284399

    Citation

    Leong, Daniel J., et al. "Nutraceuticals: Potential for Chondroprotection and Molecular Targeting of Osteoarthritis." International Journal of Molecular Sciences, vol. 14, no. 11, 2013, pp. 23063-85.
    Leong DJ, Choudhury M, Hirsh DM, et al. Nutraceuticals: potential for chondroprotection and molecular targeting of osteoarthritis. Int J Mol Sci. 2013;14(11):23063-85.
    Leong, D. J., Choudhury, M., Hirsh, D. M., Hardin, J. A., Cobelli, N. J., & Sun, H. B. (2013). Nutraceuticals: potential for chondroprotection and molecular targeting of osteoarthritis. International Journal of Molecular Sciences, 14(11), pp. 23063-85. doi:10.3390/ijms141123063.
    Leong DJ, et al. Nutraceuticals: Potential for Chondroprotection and Molecular Targeting of Osteoarthritis. Int J Mol Sci. 2013 Nov 21;14(11):23063-85. PubMed PMID: 24284399.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Nutraceuticals: potential for chondroprotection and molecular targeting of osteoarthritis. AU - Leong,Daniel J, AU - Choudhury,Marwa, AU - Hirsh,David M, AU - Hardin,John A, AU - Cobelli,Neil J, AU - Sun,Hui B, Y1 - 2013/11/21/ PY - 2013/08/16/received PY - 2013/10/30/revised PY - 2013/11/01/accepted PY - 2013/11/29/entrez PY - 2013/11/29/pubmed PY - 2014/6/4/medline SP - 23063 EP - 85 JF - International journal of molecular sciences JO - Int J Mol Sci VL - 14 IS - 11 N2 - Osteoarthritis (OA) is a degenerative joint disease and a leading cause of adult disability. There is no cure for OA, and no effective treatments which arrest or slow its progression. Current pharmacologic treatments such as analgesics may improve pain relief but do not alter OA disease progression. Prolonged consumption of these drugs can result in severe adverse effects. Given the nature of OA, life-long treatment will likely be required to arrest or slow its progression. Consequently, there is an urgent need for OA disease-modifying therapies which also improve symptoms and are safe for clinical use over long periods of time. Nutraceuticals-food or food products that provide medical or health benefits, including the prevention and/or treatment of a disease-offer not only favorable safety profiles, but may exert disease- and symptom-modification effects in OA. Forty-seven percent of OA patients use alternative medications, including nutraceuticals. This review will overview the efficacy and mechanism of action of commonly used nutraceuticals, discuss recent experimental and clinical data on the effects of select nutraceuticals, such as phytoflavonoids, polyphenols, and bioflavonoids on OA, and highlight their known molecular actions and limitations of their current use. We will conclude with a proposed novel nutraceutical-based molecular targeting strategy for chondroprotection and OA treatment. SN - 1422-0067 UR - https://www.unboundmedicine.com/medline/citation/24284399/full_citation L2 - http://www.mdpi.com/resolver?pii=ijms141123063 DB - PRIME DP - Unbound Medicine ER -