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Source of dietary fibre and diverticular disease incidence: a prospective study of UK women.
Gut 2014; 63(9):1450-6Gut

Abstract

BACKGROUND

Previous prospective studies have found the incidence of intestinal diverticular disease decreased with increasing intakes of dietary fibre, but associations by the fibre source are less well characterised. We assessed these associations in a large UK prospective study of middle-aged women.

METHODS AND FINDINGS

During 6 (SD 1) years follow-up of 690 075 women without known diverticular disease who had not changed their diet in the last 5 years, 17 325 were admitted to hospital or died with diverticular disease. Dietary fibre intake was assessed using a validated 40-item food questionnaire and remeasured 1 year later in 4265 randomly-selected women. Mean total dietary fibre intake at baseline was 13.8 (SD 5.0) g/day, of which 42% came from cereals, 22% from fruits, 19% from vegetables (not potatoes) and 15% from potatoes. The relative risk (95% CI) for diverticular disease per 5 g/day fibre intake was 0.86 (0.84 to 0.88). There was significant heterogeneity by the four main sources of fibre (p<0.0001), with relative risks, adjusted for each of the other sources of dietary fibre of 0.84 (0.81 to 0.88) per 5 g/day for cereal, 0.81 (0.77 to 0.86) per 5 g/day for fruit, 1.03 (0.93 to 1.14) per 5 g/day for vegetable and 1.04 (1.02 to 1.07) per 1 g/day for potato fibre.

CONCLUSIONS

A higher intake of dietary fibre is associated with a reduced risk of diverticular disease. The associations with diverticular disease appear to vary by fibre source, and the reasons for this variation are unclear.

Authors+Show Affiliations

Cancer Epidemiology Unit, Nuffield Department of Population Health, University of Oxford, Oxford, UK.Cancer Epidemiology Unit, Nuffield Department of Population Health, University of Oxford, Oxford, UK.Cancer Epidemiology Unit, Nuffield Department of Population Health, University of Oxford, Oxford, UK.Cancer Epidemiology Unit, Nuffield Department of Population Health, University of Oxford, Oxford, UK.Cancer Epidemiology Unit, Nuffield Department of Population Health, University of Oxford, Oxford, UK.Cancer Epidemiology Unit, Nuffield Department of Population Health, University of Oxford, Oxford, UK.Cancer Epidemiology Unit, Nuffield Department of Population Health, University of Oxford, Oxford, UK.Cancer Epidemiology Unit, Nuffield Department of Population Health, University of Oxford, Oxford, UK.No affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

24385599

Citation

Crowe, Francesca L., et al. "Source of Dietary Fibre and Diverticular Disease Incidence: a Prospective Study of UK Women." Gut, vol. 63, no. 9, 2014, pp. 1450-6.
Crowe FL, Balkwill A, Cairns BJ, et al. Source of dietary fibre and diverticular disease incidence: a prospective study of UK women. Gut. 2014;63(9):1450-6.
Crowe, F. L., Balkwill, A., Cairns, B. J., Appleby, P. N., Green, J., Reeves, G. K., ... Beral, V. (2014). Source of dietary fibre and diverticular disease incidence: a prospective study of UK women. Gut, 63(9), pp. 1450-6. doi:10.1136/gutjnl-2013-304644.
Crowe FL, et al. Source of Dietary Fibre and Diverticular Disease Incidence: a Prospective Study of UK Women. Gut. 2014;63(9):1450-6. PubMed PMID: 24385599.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Source of dietary fibre and diverticular disease incidence: a prospective study of UK women. AU - Crowe,Francesca L, AU - Balkwill,Angela, AU - Cairns,Benjamin J, AU - Appleby,Paul N, AU - Green,Jane, AU - Reeves,Gillian K, AU - Key,Timothy J, AU - Beral,Valerie, AU - ,, AU - ,, Y1 - 2014/01/02/ PY - 2014/1/4/entrez PY - 2014/1/5/pubmed PY - 2014/10/1/medline KW - diet KW - dietary fibre KW - diverticular disease KW - prospective SP - 1450 EP - 6 JF - Gut JO - Gut VL - 63 IS - 9 N2 - BACKGROUND: Previous prospective studies have found the incidence of intestinal diverticular disease decreased with increasing intakes of dietary fibre, but associations by the fibre source are less well characterised. We assessed these associations in a large UK prospective study of middle-aged women. METHODS AND FINDINGS: During 6 (SD 1) years follow-up of 690 075 women without known diverticular disease who had not changed their diet in the last 5 years, 17 325 were admitted to hospital or died with diverticular disease. Dietary fibre intake was assessed using a validated 40-item food questionnaire and remeasured 1 year later in 4265 randomly-selected women. Mean total dietary fibre intake at baseline was 13.8 (SD 5.0) g/day, of which 42% came from cereals, 22% from fruits, 19% from vegetables (not potatoes) and 15% from potatoes. The relative risk (95% CI) for diverticular disease per 5 g/day fibre intake was 0.86 (0.84 to 0.88). There was significant heterogeneity by the four main sources of fibre (p<0.0001), with relative risks, adjusted for each of the other sources of dietary fibre of 0.84 (0.81 to 0.88) per 5 g/day for cereal, 0.81 (0.77 to 0.86) per 5 g/day for fruit, 1.03 (0.93 to 1.14) per 5 g/day for vegetable and 1.04 (1.02 to 1.07) per 1 g/day for potato fibre. CONCLUSIONS: A higher intake of dietary fibre is associated with a reduced risk of diverticular disease. The associations with diverticular disease appear to vary by fibre source, and the reasons for this variation are unclear. SN - 1468-3288 UR - https://www.unboundmedicine.com/medline/citation/24385599/full_citation L2 - http://gut.bmj.com/cgi/pmidlookup?view=long&amp;pmid=24385599 DB - PRIME DP - Unbound Medicine ER -