Alcohol quantity and type on risk of recurrent gout attacks: an internet-based case-crossover study.
Am J Med. 2014 Apr; 127(4):311-8.AJ

Abstract

OBJECTIVES

Although beer and liquor have been associated with risk of incident gout, wine has not. Yet anecdotally, wine is thought to trigger gout attacks. Further, how much alcohol intake is needed to increase the risk of gout attack is not known. We examined the quantity and type of alcohol consumed on risk of recurrent gout attacks.

METHODS

We conducted a prospective Internet-based case-crossover study in the US among participants with gout and who had at least one attack during the 1 year of follow-up. We evaluated the association of alcohol intake over the prior 24 hours as well as the type of alcoholic beverage with risk of recurrent gout attack, adjusting for potential time-varying confounders.

RESULTS

This study included 724 participants with gout (78% men, mean age 54 years). There was a significant dose-response relationship between amount of alcohol consumption and risk of recurrent gout attacks (P <.001 for trend). The risk of recurrent gout attack was 1.36 (95% confidence interval [CI], 1.00-1.88) and 1.51 (95% CI, 1.09-2.09) times higher for >1-2 and >2-4 alcoholic beverages, respectively, compared with no alcohol consumption in the prior 24 hours. Consuming wine, beer, or liquor was each associated with an increased risk of gout attack.

CONCLUSIONS

Episodic alcohol consumption, regardless of type of alcoholic beverage, was associated with an increased risk of recurrent gout attacks, including potentially with moderate amounts. Individuals with gout should limit alcohol intake of all types to reduce the risk of recurrent gout attacks.

Links

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Authors+Show Affiliations

Neogi T

Clinical Epidemiology Research and Training Unit, Boston University School of Medicine, Boston, Mass. Electronic address: tneogi@bu.edu.

Chen C

Data Coordinating Center, Boston University School of Public Health, Boston, Mass.

Niu J

Clinical Epidemiology Research and Training Unit, Boston University School of Medicine, Boston, Mass.

Chaisson C

Data Coordinating Center, Boston University School of Public Health, Boston, Mass.

Hunter DJ

Kolling Institute, University of Sydney and Royal North Shore Hospital, New South Wales, Australia.

Zhang Y

Clinical Epidemiology Research and Training Unit, Boston University School of Medicine, Boston, Mass.

MeSH

AdultAgedAged, 80 and overAlcohol DrinkingAlcoholic BeveragesCross-Over StudiesFemaleGoutHumansInternetMaleMiddle AgedProspective StudiesRecurrenceRisk AssessmentYoung Adult

Pub Type(s)

Journal Article

Research Support, N.I.H., Extramural

Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

24440541

Citation

Neogi, Tuhina, et al. "Alcohol Quantity and Type On Risk of Recurrent Gout Attacks: an Internet-based Case-crossover Study." The American Journal of Medicine, vol. 127, no. 4, 2014, pp. 311-8.

Neogi T, Chen C, Niu J, et al. Alcohol quantity and type on risk of recurrent gout attacks: an internet-based case-crossover study. Am J Med. 2014;127(4):311-8.

Neogi, T., Chen, C., Niu, J., Chaisson, C., Hunter, D. J., & Zhang, Y. (2014). Alcohol quantity and type on risk of recurrent gout attacks: an internet-based case-crossover study. The American Journal of Medicine, 127(4), 311-8. https://doi.org/10.1016/j.amjmed.2013.12.019

Neogi T, et al. Alcohol Quantity and Type On Risk of Recurrent Gout Attacks: an Internet-based Case-crossover Study. Am J Med. 2014;127(4):311-8. PubMed PMID: 24440541.

* Article titles in AMA citation format should be in sentence-case

TY - JOUR T1 - Alcohol quantity and type on risk of recurrent gout attacks: an internet-based case-crossover study. AU - Neogi,Tuhina, AU - Chen,Clara, AU - Niu,Jingbo, AU - Chaisson,Christine, AU - Hunter,David J, AU - Zhang,Yuqing, Y1 - 2014/01/17/ PY - 2013/09/20/received PY - 2013/12/23/revised PY - 2013/12/26/accepted PY - 2014/1/21/entrez PY - 2014/1/21/pubmed PY - 2014/5/13/medline KW - Alcohol KW - Case-crossover KW - Gout attacks KW - Internet KW - Triggers SP - 311 EP - 8 JF - The American journal of medicine JO - Am J Med VL - 127 IS - 4 N2 - OBJECTIVES: Although beer and liquor have been associated with risk of incident gout, wine has not. Yet anecdotally, wine is thought to trigger gout attacks. Further, how much alcohol intake is needed to increase the risk of gout attack is not known. We examined the quantity and type of alcohol consumed on risk of recurrent gout attacks. METHODS: We conducted a prospective Internet-based case-crossover study in the US among participants with gout and who had at least one attack during the 1 year of follow-up. We evaluated the association of alcohol intake over the prior 24 hours as well as the type of alcoholic beverage with risk of recurrent gout attack, adjusting for potential time-varying confounders. RESULTS: This study included 724 participants with gout (78% men, mean age 54 years). There was a significant dose-response relationship between amount of alcohol consumption and risk of recurrent gout attacks (P <.001 for trend). The risk of recurrent gout attack was 1.36 (95% confidence interval [CI], 1.00-1.88) and 1.51 (95% CI, 1.09-2.09) times higher for >1-2 and >2-4 alcoholic beverages, respectively, compared with no alcohol consumption in the prior 24 hours. Consuming wine, beer, or liquor was each associated with an increased risk of gout attack. CONCLUSIONS: Episodic alcohol consumption, regardless of type of alcoholic beverage, was associated with an increased risk of recurrent gout attacks, including potentially with moderate amounts. Individuals with gout should limit alcohol intake of all types to reduce the risk of recurrent gout attacks. SN - 1555-7162 UR - https://www.unboundmedicine.com/medline/citation/24440541/full_citation DB - PRIME DP - Unbound Medicine ER -

Tags

Alcohol quantity and type on risk of recurrent gout attacks: an internet-based case-crossover study.Am J Med. 2014 Apr; 127(4):311-8.AJ