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Modifying effect of N-acetyltransferase 2 genotype on the association between systemic lupus erythematosus and consumption of alcohol and caffeine-rich beverages.
Arthritis Care Res (Hoboken) 2014; 66(7):1048-56AC

Abstract

OBJECTIVE

N-acetyltransferase 2 (NAT2) is involved in the metabolism of various environmental substances, both with and without carcinogenic potential. Alcoholic and nonalcoholic caffeine-rich beverages may be associated with markers of inflammation. Systemic lupus erythematosus (SLE) is a chronic, multifaceted inflammatory disease. We investigated the effects of alcoholic and nonalcoholic caffeine-rich beverages on risk of SLE and determined whether the effects were modified by NAT2 status.

METHODS

The NAT2 polymorphism was genotyped in 152 SLE cases and 427 healthy controls, all women and Japanese. We assessed effect modification by testing an interaction term for the NAT2 polymorphism and consumption of beverages.

RESULTS

Consumption of black tea (odds ratio [OR] 1.88, 95% confidence interval [95% CI] 1.03-3.41) and coffee (OR 1.57, 95% CI 0.95-2.61), but not green tea, was associated with an increased risk of SLE, while alcohol use (OR 0.33, 95% CI 0.20-0.55) was associated with a decreased risk of SLE. There were significant interactions between the NAT2 polymorphism and either alcohol use (Pinteraction = 0.026) or consumption of black tea (Pinteraction = 0.048).

CONCLUSION

The NAT2 polymorphism significantly modified the effects of alcohol use and black tea consumption on SLE, emphasizing the importance of incorporating genetic and metabolic information in studies on management of SLE. Additional studies are warranted to confirm the findings suggested in this study.

Authors+Show Affiliations

Kyushu University, Fukuoka, Japan.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Randomized Controlled Trial
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

24470392

Citation

Kiyohara, Chikako, et al. "Modifying Effect of N-acetyltransferase 2 Genotype On the Association Between Systemic Lupus Erythematosus and Consumption of Alcohol and Caffeine-rich Beverages." Arthritis Care & Research, vol. 66, no. 7, 2014, pp. 1048-56.
Kiyohara C, Washio M, Horiuchi T, et al. Modifying effect of N-acetyltransferase 2 genotype on the association between systemic lupus erythematosus and consumption of alcohol and caffeine-rich beverages. Arthritis Care Res (Hoboken). 2014;66(7):1048-56.
Kiyohara, C., Washio, M., Horiuchi, T., Asami, T., Ide, S., Atsumi, T., ... Tada, Y. (2014). Modifying effect of N-acetyltransferase 2 genotype on the association between systemic lupus erythematosus and consumption of alcohol and caffeine-rich beverages. Arthritis Care & Research, 66(7), pp. 1048-56. doi:10.1002/acr.22282.
Kiyohara C, et al. Modifying Effect of N-acetyltransferase 2 Genotype On the Association Between Systemic Lupus Erythematosus and Consumption of Alcohol and Caffeine-rich Beverages. Arthritis Care Res (Hoboken). 2014;66(7):1048-56. PubMed PMID: 24470392.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Modifying effect of N-acetyltransferase 2 genotype on the association between systemic lupus erythematosus and consumption of alcohol and caffeine-rich beverages. AU - Kiyohara,Chikako, AU - Washio,Masakazu, AU - Horiuchi,Takahiko, AU - Asami,Toyoko, AU - Ide,Saburo, AU - Atsumi,Tatsuya, AU - Kobashi,Gen, AU - Takahashi,Hiroki, AU - Tada,Yoshifumi, AU - ,, PY - 2013/09/27/received PY - 2014/01/02/accepted PY - 2014/1/29/entrez PY - 2014/1/29/pubmed PY - 2014/9/2/medline SP - 1048 EP - 56 JF - Arthritis care & research JO - Arthritis Care Res (Hoboken) VL - 66 IS - 7 N2 - OBJECTIVE: N-acetyltransferase 2 (NAT2) is involved in the metabolism of various environmental substances, both with and without carcinogenic potential. Alcoholic and nonalcoholic caffeine-rich beverages may be associated with markers of inflammation. Systemic lupus erythematosus (SLE) is a chronic, multifaceted inflammatory disease. We investigated the effects of alcoholic and nonalcoholic caffeine-rich beverages on risk of SLE and determined whether the effects were modified by NAT2 status. METHODS: The NAT2 polymorphism was genotyped in 152 SLE cases and 427 healthy controls, all women and Japanese. We assessed effect modification by testing an interaction term for the NAT2 polymorphism and consumption of beverages. RESULTS: Consumption of black tea (odds ratio [OR] 1.88, 95% confidence interval [95% CI] 1.03-3.41) and coffee (OR 1.57, 95% CI 0.95-2.61), but not green tea, was associated with an increased risk of SLE, while alcohol use (OR 0.33, 95% CI 0.20-0.55) was associated with a decreased risk of SLE. There were significant interactions between the NAT2 polymorphism and either alcohol use (Pinteraction = 0.026) or consumption of black tea (Pinteraction = 0.048). CONCLUSION: The NAT2 polymorphism significantly modified the effects of alcohol use and black tea consumption on SLE, emphasizing the importance of incorporating genetic and metabolic information in studies on management of SLE. Additional studies are warranted to confirm the findings suggested in this study. SN - 2151-4658 UR - https://www.unboundmedicine.com/medline/citation/24470392/full_citation L2 - https://doi.org/10.1002/acr.22282 DB - PRIME DP - Unbound Medicine ER -