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Coffee consumption and risk of fractures: a systematic review and dose-response meta-analysis.
Bone 2014; 63:20-8BONE

Abstract

PURPOSE

The data on the association between coffee consumption and the risk of fractures are inconclusive. We performed a comprehensive literature review and meta-analysis to better quantify this association.

METHODS

We identified all potentially relevant articles by searching MEDLINE, EMBASE, Cochrane Library, Web of Science, SCOPUS, and CINAHL (until February 2013). The keywords "coffee," "caffeine," "drink," and "beverage" were used as the exposure factors, and the keyword "fracture" was used as the outcome factor. We determined the overall relative risk (RR) and confidence interval (CI) for the highest and lowest levels of coffee consumption. A dose-response analysis was performed to assess the risk of fractures based on the level of coffee consumption.

RESULTS

We included 253,514 participants with 12,939 fracture cases from 9 cohort and 6 case-control studies. The estimated RR of fractures at the highest level of coffee consumption was 1.14 (95% CI: 1.05-1.24; I(2)=0.0%) in women and 0.76 (95% CI: 0.62-0.94; I(2)=7.3%) in men. In the dose-response analysis, the pooled RRs of fractures in women who consumed 2 and 8 cups of coffee per day were 1.02 (95% CI: 1.01-1.04) and 1.54 (95% CI: 1.19-1.99), respectively.

CONCLUSIONS

Our meta-analysis suggests that daily consumption of coffee is associated with an increased risk of fractures in women and a contrasting decreased risk in men. However, future well-designed studies should be performed to confirm these findings.

Authors+Show Affiliations

Department of Family Medicine, Wonkwang University Sanbon Hospital, Wonkwang University School of Medicine, Gunpo, Republic of Korea. Electronic address: rednose7695@gmail.com.Department of Family Medicine, Wonkwang University Sanbon Hospital, Wonkwang University School of Medicine, Gunpo, Republic of Korea. Electronic address: tracheo@naver.com.Department of Health Sciences, Centre of Biostatistics for Clinical Epidemiology, University of Milan-Bicocca, Monza, Italy; Dipartimento di Epidemiologia, IRCCS - Istituto di Ricerche Farmacologiche "Mario Negri", Milano, Italy. Electronic address: rota.matteo@libero.it.Department of Biostatistics, Korea University College of Medicine, Seoul, Republic of Korea. Electronic address: jyleeuf@korea.ac.kr.Department of Preventive Medicine, College of Medicine, Korea University, Seoul, Republic of Korea. Electronic address: hsahn@korea.ac.kr.Department of Family Medicine, Seoul National University Hospital, Seoul National University College of Medicine, Republic of Korea; Department of Biomedical Sciences, Seoul National University College of Medicine, 101 Daehangno, Jongno-gu, Seoul 110-744, Republic of Korea. Electronic address: smpark.snuh@gmail.com.Jangseong Public Health Center, Jangseong, Republic of Korea. Electronic address: doosup87@gmail.com.

Pub Type(s)

Journal Article
Meta-Analysis
Research Support, Non-U.S. Gov't
Review
Systematic Review

Language

eng

PubMed ID

24576685

Citation

Lee, Dong Ryul, et al. "Coffee Consumption and Risk of Fractures: a Systematic Review and Dose-response Meta-analysis." Bone, vol. 63, 2014, pp. 20-8.
Lee DR, Lee J, Rota M, et al. Coffee consumption and risk of fractures: a systematic review and dose-response meta-analysis. Bone. 2014;63:20-8.
Lee, D. R., Lee, J., Rota, M., Lee, J., Ahn, H. S., Park, S. M., & Shin, D. (2014). Coffee consumption and risk of fractures: a systematic review and dose-response meta-analysis. Bone, 63, pp. 20-8. doi:10.1016/j.bone.2014.02.007.
Lee DR, et al. Coffee Consumption and Risk of Fractures: a Systematic Review and Dose-response Meta-analysis. Bone. 2014;63:20-8. PubMed PMID: 24576685.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Coffee consumption and risk of fractures: a systematic review and dose-response meta-analysis. AU - Lee,Dong Ryul, AU - Lee,Jungun, AU - Rota,Matteo, AU - Lee,Juneyoung, AU - Ahn,Hyeong Sik, AU - Park,Sang Min, AU - Shin,Doosup, Y1 - 2014/02/24/ PY - 2013/08/07/received PY - 2014/01/28/revised PY - 2014/02/15/accepted PY - 2014/3/1/entrez PY - 2014/3/1/pubmed PY - 2014/12/17/medline KW - Caffeine KW - Coffee KW - Dose–response relationship KW - Fracture KW - Meta-analysis SP - 20 EP - 8 JF - Bone JO - Bone VL - 63 N2 - PURPOSE: The data on the association between coffee consumption and the risk of fractures are inconclusive. We performed a comprehensive literature review and meta-analysis to better quantify this association. METHODS: We identified all potentially relevant articles by searching MEDLINE, EMBASE, Cochrane Library, Web of Science, SCOPUS, and CINAHL (until February 2013). The keywords "coffee," "caffeine," "drink," and "beverage" were used as the exposure factors, and the keyword "fracture" was used as the outcome factor. We determined the overall relative risk (RR) and confidence interval (CI) for the highest and lowest levels of coffee consumption. A dose-response analysis was performed to assess the risk of fractures based on the level of coffee consumption. RESULTS: We included 253,514 participants with 12,939 fracture cases from 9 cohort and 6 case-control studies. The estimated RR of fractures at the highest level of coffee consumption was 1.14 (95% CI: 1.05-1.24; I(2)=0.0%) in women and 0.76 (95% CI: 0.62-0.94; I(2)=7.3%) in men. In the dose-response analysis, the pooled RRs of fractures in women who consumed 2 and 8 cups of coffee per day were 1.02 (95% CI: 1.01-1.04) and 1.54 (95% CI: 1.19-1.99), respectively. CONCLUSIONS: Our meta-analysis suggests that daily consumption of coffee is associated with an increased risk of fractures in women and a contrasting decreased risk in men. However, future well-designed studies should be performed to confirm these findings. SN - 1873-2763 UR - https://www.unboundmedicine.com/medline/citation/24576685/full_citation L2 - https://linkinghub.elsevier.com/retrieve/pii/S8756-3282(14)00044-1 DB - PRIME DP - Unbound Medicine ER -