Prime

Type your tag names separated by a space and hit enter

Brain tocopherols related to Alzheimer's disease neuropathology in humans.

Abstract

Randomized trials of α-tocopherol supplements on cognitive decline are negative, whereas studies of dietary tocopherols have shown benefit. We investigated these inconsistencies by analyzing the relations of α- and γ-tocopherol brain concentrations to Alzheimer's disease (AD) neuropathology among 115 deceased participants of the prospective Rush Memory and Aging Project. Associations of amyloid load and neurofibrillary tangle severity with brain tocopherol concentrations were examined in separate adjusted linear regression models. γ-Tocopherol concentrations were associated with lower amyloid load (β = -2.10, P = .002) and lower neurofibrillary tangle severity (β = -1.16, P = .02). Concentrations of α-tocopherol were not associated with AD neuropathology, except as modified by γ-tocopherol: high α-tocopherol was associated with higher amyloid load when γ-tocopherol levels were low and with lower amyloid levels when γ-tocopherol levels were high (P for interaction = 0.03). Brain concentrations of γ- and α-tocopherols may be associated with AD neuropathology in interrelated, complex ways. Randomized trials should consider the contribution of γ-tocopherol.

Links

  • PMC Free PDF
  • Aggregator Full Text
  • Authors+Show Affiliations

    ,

    Section on Nutrition and Nutritional Epidemiology, Department of Internal Medicine, Rush Alzheimer Disease Center, Rush University Medical Center, Chicago, IL, USA. Electronic address: martha_c_morris@rush.edu.

    ,

    Department of Neurology, Rush University Medical Center, Chicago, IL, USA; Department of Pathology, Rush University Medical Center, Chicago, IL, USA.

    ,

    Section on Nutrition and Nutritional Epidemiology, Department of Internal Medicine, Rush Alzheimer Disease Center, Rush University Medical Center, Chicago, IL, USA.

    ,

    Department of Clinical Nutrition, Rush University Medical Center, Chicago, IL, USA.

    ,

    Department of Neurology, Rush University Medical Center, Chicago, IL, USA; Department of Pathology, Rush University Medical Center, Chicago, IL, USA.

    ,

    Department of Neurology, Rush University Medical Center, Chicago, IL, USA.

    ,

    Department of Psychiatry, University of British Columbia, Vancouver, BC, Canada.

    Department of Neurology, Rush University Medical Center, Chicago, IL, USA.

    Source

    MeSH

    Aged
    Aged, 80 and over
    Aging
    Alzheimer Disease
    Brain
    Cohort Studies
    Female
    Humans
    Male
    Neurofibrillary Tangles
    Plaque, Amyloid
    alpha-Tocopherol
    gamma-Tocopherol

    Pub Type(s)

    Journal Article
    Research Support, N.I.H., Extramural

    Language

    eng

    PubMed ID

    24589434

    Citation

    TY - JOUR T1 - Brain tocopherols related to Alzheimer's disease neuropathology in humans. AU - Morris,Martha Clare, AU - Schneider,Julie A, AU - Li,Hong, AU - Tangney,Christy C, AU - Nag,Sukriti, AU - Bennett,David A, AU - Honer,William G, AU - Barnes,Lisa L, Y1 - 2014/02/28/ PY - 2013/4/17/received PY - 2013/11/25/revised PY - 2013/12/17/accepted PY - 2014/2/28/aheadofprint PY - 2014/3/5/entrez PY - 2016/1/1/pmc-release PY - 2014/3/5/pubmed PY - 2015/7/15/medline KW - Alzheimer's disease KW - Amyloid beta KW - Cohort studies KW - Neurofiibrillary tangles KW - Nutritional KW - Tocopherols KW - Vitamin E SP - 32 EP - 9 JF - Alzheimer's & dementia : the journal of the Alzheimer's Association JO - Alzheimers Dement VL - 11 IS - 1 N2 - Randomized trials of α-tocopherol supplements on cognitive decline are negative, whereas studies of dietary tocopherols have shown benefit. We investigated these inconsistencies by analyzing the relations of α- and γ-tocopherol brain concentrations to Alzheimer's disease (AD) neuropathology among 115 deceased participants of the prospective Rush Memory and Aging Project. Associations of amyloid load and neurofibrillary tangle severity with brain tocopherol concentrations were examined in separate adjusted linear regression models. γ-Tocopherol concentrations were associated with lower amyloid load (β = -2.10, P = .002) and lower neurofibrillary tangle severity (β = -1.16, P = .02). Concentrations of α-tocopherol were not associated with AD neuropathology, except as modified by γ-tocopherol: high α-tocopherol was associated with higher amyloid load when γ-tocopherol levels were low and with lower amyloid levels when γ-tocopherol levels were high (P for interaction = 0.03). Brain concentrations of γ- and α-tocopherols may be associated with AD neuropathology in interrelated, complex ways. Randomized trials should consider the contribution of γ-tocopherol. SN - 1552-5279 UR - https://www.unboundmedicine.com/medline/citation/24589434/full_citation L2 - https://www.clinicalkey.com/content/playBy/pii?v=S1552-5260(13)02942-7 ER -