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Brain tocopherols related to Alzheimer's disease neuropathology in humans.
Alzheimers Dement. 2015 Jan; 11(1):32-9.AD

Abstract

Randomized trials of α-tocopherol supplements on cognitive decline are negative, whereas studies of dietary tocopherols have shown benefit. We investigated these inconsistencies by analyzing the relations of α- and γ-tocopherol brain concentrations to Alzheimer's disease (AD) neuropathology among 115 deceased participants of the prospective Rush Memory and Aging Project. Associations of amyloid load and neurofibrillary tangle severity with brain tocopherol concentrations were examined in separate adjusted linear regression models. γ-Tocopherol concentrations were associated with lower amyloid load (β = -2.10, P = .002) and lower neurofibrillary tangle severity (β = -1.16, P = .02). Concentrations of α-tocopherol were not associated with AD neuropathology, except as modified by γ-tocopherol: high α-tocopherol was associated with higher amyloid load when γ-tocopherol levels were low and with lower amyloid levels when γ-tocopherol levels were high (P for interaction = 0.03). Brain concentrations of γ- and α-tocopherols may be associated with AD neuropathology in interrelated, complex ways. Randomized trials should consider the contribution of γ-tocopherol.

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Authors+Show Affiliations

Morris MC
Section on Nutrition and Nutritional Epidemiology, Department of Internal Medicine, Rush Alzheimer Disease Center, Rush University Medical Center, Chicago, IL, USA. Electronic address: martha_c_morris@rush.edu.
Schneider JA
Department of Neurology, Rush University Medical Center, Chicago, IL, USA; Department of Pathology, Rush University Medical Center, Chicago, IL, USA.
Li H
Section on Nutrition and Nutritional Epidemiology, Department of Internal Medicine, Rush Alzheimer Disease Center, Rush University Medical Center, Chicago, IL, USA.
Tangney CC
Department of Clinical Nutrition, Rush University Medical Center, Chicago, IL, USA.
Nag S
Department of Neurology, Rush University Medical Center, Chicago, IL, USA; Department of Pathology, Rush University Medical Center, Chicago, IL, USA.
Bennett DA
Department of Neurology, Rush University Medical Center, Chicago, IL, USA.
Honer WG
Department of Psychiatry, University of British Columbia, Vancouver, BC, Canada.
Barnes LL
Department of Neurology, Rush University Medical Center, Chicago, IL, USA.

MeSH

AgedAged, 80 and overAgingAlzheimer DiseaseBrainCohort StudiesFemaleHumansMaleNeurofibrillary TanglesPlaque, Amyloidalpha-Tocopherolgamma-Tocopherol

Pub Type(s)

Journal Article
Research Support, N.I.H., Extramural

Language

eng

PubMed ID

24589434

Citation

Morris, Martha Clare, et al. "Brain Tocopherols Related to Alzheimer's Disease Neuropathology in Humans." Alzheimer's & Dementia : the Journal of the Alzheimer's Association, vol. 11, no. 1, 2015, pp. 32-9.
Morris MC, Schneider JA, Li H, et al. Brain tocopherols related to Alzheimer's disease neuropathology in humans. Alzheimers Dement. 2015;11(1):32-9.
Morris, M. C., Schneider, J. A., Li, H., Tangney, C. C., Nag, S., Bennett, D. A., Honer, W. G., & Barnes, L. L. (2015). Brain tocopherols related to Alzheimer's disease neuropathology in humans. Alzheimer's & Dementia : the Journal of the Alzheimer's Association, 11(1), 32-9. https://doi.org/10.1016/j.jalz.2013.12.015
Morris MC, et al. Brain Tocopherols Related to Alzheimer's Disease Neuropathology in Humans. Alzheimers Dement. 2015;11(1):32-9. PubMed PMID: 24589434.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Brain tocopherols related to Alzheimer's disease neuropathology in humans. AU - Morris,Martha Clare, AU - Schneider,Julie A, AU - Li,Hong, AU - Tangney,Christy C, AU - Nag,Sukriti, AU - Bennett,David A, AU - Honer,William G, AU - Barnes,Lisa L, Y1 - 2014/02/28/ PY - 2013/04/17/received PY - 2013/11/25/revised PY - 2013/12/17/accepted PY - 2014/3/5/entrez PY - 2014/3/5/pubmed PY - 2015/7/15/medline KW - Alzheimer's disease KW - Amyloid beta KW - Cohort studies KW - Neurofiibrillary tangles KW - Nutritional KW - Tocopherols KW - Vitamin E SP - 32 EP - 9 JF - Alzheimer's & dementia : the journal of the Alzheimer's Association JO - Alzheimers Dement VL - 11 IS - 1 N2 - Randomized trials of α-tocopherol supplements on cognitive decline are negative, whereas studies of dietary tocopherols have shown benefit. We investigated these inconsistencies by analyzing the relations of α- and γ-tocopherol brain concentrations to Alzheimer's disease (AD) neuropathology among 115 deceased participants of the prospective Rush Memory and Aging Project. Associations of amyloid load and neurofibrillary tangle severity with brain tocopherol concentrations were examined in separate adjusted linear regression models. γ-Tocopherol concentrations were associated with lower amyloid load (β = -2.10, P = .002) and lower neurofibrillary tangle severity (β = -1.16, P = .02). Concentrations of α-tocopherol were not associated with AD neuropathology, except as modified by γ-tocopherol: high α-tocopherol was associated with higher amyloid load when γ-tocopherol levels were low and with lower amyloid levels when γ-tocopherol levels were high (P for interaction = 0.03). Brain concentrations of γ- and α-tocopherols may be associated with AD neuropathology in interrelated, complex ways. Randomized trials should consider the contribution of γ-tocopherol. SN - 1552-5279 UR - https://www.unboundmedicine.com/medline/citation/24589434/full_citation DB - PRIME DP - Unbound Medicine ER -