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Alcohol intake and risk of Parkinson's disease: a meta-analysis of observational studies.

Abstract

BACKGROUND

The association of alcohol intake with risk of Parkinson's disease remains unclear.

METHODS

Pertinent studies were identified in PubMed and EMBASE. The fixed-effect or random-effect model was selected based on heterogeneity. The dose-response relationship was assessed by restricted cubic splines.

RESULTS

We included 32 articles, involving 677,550 subjects (9994 cases). The smoking-adjusted risk of Parkinson's disease for the highest versus lowest level of alcohol intake was relative risk (RR) 0.78 (95% confidence interval [CI], 0.67-0.92) overall, 0.86 (95% CI, 0.75-0.995) in prospective studies, and 0.74 (95% CI, 0.58-0.96) in matched case-control studies. A significant association was found with beer (0.59; 95% CI, 0.39-0.90) but not with wine and liquor, and for males (0.65; 95% CI, 0.47-0.90) after a sensitivity analysis but not for females. The risk of Parkinson's disease decreased by 5% (0.95; 95% CI, 0.89-1.02) for every 1 drink/day increment in alcohol intake in a linear (Pfor nonlinearity  = 0.85) dose-response manner.

CONCLUSIONS

Alcohol intake, especially beer, might be inversely associated with risk of Parkinson's disease

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  • Publisher Full Text
  • Authors+Show Affiliations

    ,

    Department of Epidemiology and Health Statistics, Qingdao University Medical College, Qingdao, P.R. China.

    ,

    Source

    MeSH

    Alcohol Drinking
    Databases, Bibliographic
    Female
    Humans
    Male
    Parkinson Disease
    Risk

    Pub Type(s)

    Journal Article
    Meta-Analysis
    Observational Study
    Research Support, Non-U.S. Gov't

    Language

    eng

    PubMed ID

    24590499

    Citation

    TY - JOUR T1 - Alcohol intake and risk of Parkinson's disease: a meta-analysis of observational studies. AU - Zhang,Dongfeng, AU - Jiang,Hong, AU - Xie,Junxia, Y1 - 2014/03/03/ PY - 2013/11/3/received PY - 2014/2/9/revised PY - 2014/2/13/accepted PY - 2014/3/3/aheadofprint PY - 2014/3/5/entrez PY - 2014/3/5/pubmed PY - 2014/12/20/medline KW - Parkinson's disease KW - alcohol KW - meta-analysis KW - observational study SP - 819 EP - 22 JF - Movement disorders : official journal of the Movement Disorder Society JO - Mov. Disord. VL - 29 IS - 6 N2 - BACKGROUND: The association of alcohol intake with risk of Parkinson's disease remains unclear. METHODS: Pertinent studies were identified in PubMed and EMBASE. The fixed-effect or random-effect model was selected based on heterogeneity. The dose-response relationship was assessed by restricted cubic splines. RESULTS: We included 32 articles, involving 677,550 subjects (9994 cases). The smoking-adjusted risk of Parkinson's disease for the highest versus lowest level of alcohol intake was relative risk (RR) 0.78 (95% confidence interval [CI], 0.67-0.92) overall, 0.86 (95% CI, 0.75-0.995) in prospective studies, and 0.74 (95% CI, 0.58-0.96) in matched case-control studies. A significant association was found with beer (0.59; 95% CI, 0.39-0.90) but not with wine and liquor, and for males (0.65; 95% CI, 0.47-0.90) after a sensitivity analysis but not for females. The risk of Parkinson's disease decreased by 5% (0.95; 95% CI, 0.89-1.02) for every 1 drink/day increment in alcohol intake in a linear (Pfor nonlinearity  = 0.85) dose-response manner. CONCLUSIONS: Alcohol intake, especially beer, might be inversely associated with risk of Parkinson's disease SN - 1531-8257 UR - https://www.unboundmedicine.com/medline/citation/24590499/full_citation L2 - http://dx.doi.org/10.1002/mds.25863 ER -