Tags

Type your tag names separated by a space and hit enter

Alcohol intake and risk of Parkinson's disease: a meta-analysis of observational studies.
Mov Disord 2014; 29(6):819-22MD

Abstract

BACKGROUND

The association of alcohol intake with risk of Parkinson's disease remains unclear.

METHODS

Pertinent studies were identified in PubMed and EMBASE. The fixed-effect or random-effect model was selected based on heterogeneity. The dose-response relationship was assessed by restricted cubic splines.

RESULTS

We included 32 articles, involving 677,550 subjects (9994 cases). The smoking-adjusted risk of Parkinson's disease for the highest versus lowest level of alcohol intake was relative risk (RR) 0.78 (95% confidence interval [CI], 0.67-0.92) overall, 0.86 (95% CI, 0.75-0.995) in prospective studies, and 0.74 (95% CI, 0.58-0.96) in matched case-control studies. A significant association was found with beer (0.59; 95% CI, 0.39-0.90) but not with wine and liquor, and for males (0.65; 95% CI, 0.47-0.90) after a sensitivity analysis but not for females. The risk of Parkinson's disease decreased by 5% (0.95; 95% CI, 0.89-1.02) for every 1 drink/day increment in alcohol intake in a linear (Pfor nonlinearity = 0.85) dose-response manner.

CONCLUSIONS

Alcohol intake, especially beer, might be inversely associated with risk of Parkinson's disease

Authors+Show Affiliations

Department of Epidemiology and Health Statistics, Qingdao University Medical College, Qingdao, P.R. China.No affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Meta-Analysis
Observational Study
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

24590499

Citation

Zhang, Dongfeng, et al. "Alcohol Intake and Risk of Parkinson's Disease: a Meta-analysis of Observational Studies." Movement Disorders : Official Journal of the Movement Disorder Society, vol. 29, no. 6, 2014, pp. 819-22.
Zhang D, Jiang H, Xie J. Alcohol intake and risk of Parkinson's disease: a meta-analysis of observational studies. Mov Disord. 2014;29(6):819-22.
Zhang, D., Jiang, H., & Xie, J. (2014). Alcohol intake and risk of Parkinson's disease: a meta-analysis of observational studies. Movement Disorders : Official Journal of the Movement Disorder Society, 29(6), pp. 819-22. doi:10.1002/mds.25863.
Zhang D, Jiang H, Xie J. Alcohol Intake and Risk of Parkinson's Disease: a Meta-analysis of Observational Studies. Mov Disord. 2014;29(6):819-22. PubMed PMID: 24590499.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Alcohol intake and risk of Parkinson's disease: a meta-analysis of observational studies. AU - Zhang,Dongfeng, AU - Jiang,Hong, AU - Xie,Junxia, Y1 - 2014/03/03/ PY - 2013/11/03/received PY - 2014/02/09/revised PY - 2014/02/13/accepted PY - 2014/3/5/entrez PY - 2014/3/5/pubmed PY - 2014/12/20/medline KW - Parkinson's disease KW - alcohol KW - meta-analysis KW - observational study SP - 819 EP - 22 JF - Movement disorders : official journal of the Movement Disorder Society JO - Mov. Disord. VL - 29 IS - 6 N2 - BACKGROUND: The association of alcohol intake with risk of Parkinson's disease remains unclear. METHODS: Pertinent studies were identified in PubMed and EMBASE. The fixed-effect or random-effect model was selected based on heterogeneity. The dose-response relationship was assessed by restricted cubic splines. RESULTS: We included 32 articles, involving 677,550 subjects (9994 cases). The smoking-adjusted risk of Parkinson's disease for the highest versus lowest level of alcohol intake was relative risk (RR) 0.78 (95% confidence interval [CI], 0.67-0.92) overall, 0.86 (95% CI, 0.75-0.995) in prospective studies, and 0.74 (95% CI, 0.58-0.96) in matched case-control studies. A significant association was found with beer (0.59; 95% CI, 0.39-0.90) but not with wine and liquor, and for males (0.65; 95% CI, 0.47-0.90) after a sensitivity analysis but not for females. The risk of Parkinson's disease decreased by 5% (0.95; 95% CI, 0.89-1.02) for every 1 drink/day increment in alcohol intake in a linear (Pfor nonlinearity = 0.85) dose-response manner. CONCLUSIONS: Alcohol intake, especially beer, might be inversely associated with risk of Parkinson's disease SN - 1531-8257 UR - https://www.unboundmedicine.com/medline/citation/24590499/full_citation L2 - https://doi.org/10.1002/mds.25863 DB - PRIME DP - Unbound Medicine ER -