Citation
van Nielen, Monique, et al. "Dietary Protein Intake and Incidence of Type 2 Diabetes in Europe: the EPIC-InterAct Case-Cohort Study." Diabetes Care, vol. 37, no. 7, 2014, pp. 1854-62.
van Nielen M, Feskens EJ, Mensink M, et al. Dietary protein intake and incidence of type 2 diabetes in Europe: the EPIC-InterAct Case-Cohort Study. Diabetes Care. 2014;37(7):1854-62.
van Nielen, M., Feskens, E. J., Mensink, M., Sluijs, I., Molina, E., Amiano, P., Ardanaz, E., Balkau, B., Beulens, J. W., Boeing, H., Clavel-Chapelon, F., Fagherazzi, G., Franks, P. W., Halkjaer, J., Huerta, J. M., Katzke, V., Key, T. J., Khaw, K. T., Krogh, V., ... Wareham, N. J. (2014). Dietary protein intake and incidence of type 2 diabetes in Europe: the EPIC-InterAct Case-Cohort Study. Diabetes Care, 37(7), 1854-62. https://doi.org/10.2337/dc13-2627
van Nielen M, et al. Dietary Protein Intake and Incidence of Type 2 Diabetes in Europe: the EPIC-InterAct Case-Cohort Study. Diabetes Care. 2014;37(7):1854-62. PubMed PMID: 24722499.
TY - JOUR
T1 - Dietary protein intake and incidence of type 2 diabetes in Europe: the EPIC-InterAct Case-Cohort Study.
AU - van Nielen,Monique,
AU - Feskens,Edith J M,
AU - Mensink,Marco,
AU - Sluijs,Ivonne,
AU - Molina,Esther,
AU - Amiano,Pilar,
AU - Ardanaz,Eva,
AU - Balkau,Beverly,
AU - Beulens,Joline W J,
AU - Boeing,Heiner,
AU - Clavel-Chapelon,Françoise,
AU - Fagherazzi,Guy,
AU - Franks,Paul W,
AU - Halkjaer,Jytte,
AU - Huerta,José Maria,
AU - Katzke,Verena,
AU - Key,Timothy J,
AU - Khaw,Kay Tee,
AU - Krogh,Vittorio,
AU - Kühn,Tilman,
AU - Menéndez,Virginia V M,
AU - Nilsson,Peter,
AU - Overvad,Kim,
AU - Palli,Domenico,
AU - Panico,Salvatore,
AU - Rolandsson,Olov,
AU - Romieu,Isabelle,
AU - Sacerdote,Carlotta,
AU - Sánchez,Maria-José,
AU - Schulze,Matthias B,
AU - Spijkerman,Annemieke M W,
AU - Tjonneland,Anne,
AU - Tumino,Rosario,
AU - van der A,Daphne L,
AU - Würtz,Anne M L,
AU - Zamora-Ros,Raul,
AU - Langenberg,Claudia,
AU - Sharp,Stephen J,
AU - Forouhi,Nita G,
AU - Riboli,Elio,
AU - Wareham,Nicholas J,
AU - ,,
Y1 - 2014/04/10/
PY - 2014/4/12/entrez
PY - 2014/4/12/pubmed
PY - 2014/12/15/medline
SP - 1854
EP - 62
JF - Diabetes care
JO - Diabetes Care
VL - 37
IS - 7
N2 - OBJECTIVE: The long-term association between dietary protein and type 2 diabetes incidence is uncertain. We aimed to investigate the association between total, animal, and plant protein intake and the incidence of type 2 diabetes. RESEARCH DESIGN AND METHODS: The prospective European Prospective Investigation into Cancer and Nutrition (EPIC)-InterAct case-cohort study consists of 12,403 incident type 2 diabetes cases and a stratified subcohort of 16,154 individuals from eight European countries, with an average follow-up time of 12.0 years. Pooled country-specific hazard ratios (HRs) and 95% CI of prentice-weighted Cox regression analyses were used to estimate type 2 diabetes incidence according to protein intake. RESULTS: After adjustment for important diabetes risk factors and dietary factors, the incidence of type 2 diabetes was higher in those with high intake of total protein (per 10 g: HR 1.06 [95% CI 1.02-1.09], P(trend) < 0.001) and animal protein (per 10 g: 1.05 [1.02-1.08], P(trend) = 0.001). Effect modification by sex (P < 0.001) and BMI among women (P < 0.001) was observed. Compared with the overall analyses, associations were stronger in women, more specifically obese women with a BMI >30 kg/m(2) (per 10 g animal protein: 1.19 [1.09-1.32]), and nonsignificant in men. Plant protein intake was not associated with type 2 diabetes (per 10 g: 1.04 [0.93-1.16], P(trend) = 0.098). CONCLUSIONS: High total and animal protein intake was associated with a modest elevated risk of type 2 diabetes in a large cohort of European adults. In view of the rapidly increasing prevalence of type 2 diabetes, limiting iso-energetic diets high in dietary proteins, particularly from animal sources, should be considered.
SN - 1935-5548
UR - https://www.unboundmedicine.com/medline/citation/24722499/full_citation
DB - PRIME
DP - Unbound Medicine
ER -
