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Cross-sectional analysis of obesity and serum analytes in males identifies sRAGE as a novel biomarker inversely associated with diverticulosis.

Abstract

Diverticulosis can lead to diverticulitis, a colon condition involving inflammation and other complications. Diverticulosis can result from biological, behavioral, or genetic causes. However, the etiology of diverticulosis is unknown. Although diet is associated with diverticulosis, recent studies suggest other factors influence risk. We sought to identify anthropometric or serum markers that were associated with the presence of diverticulosis. To determine these associations, 126 asymptomatic men (48-65 yr) were recruited at the time of preventative screening colonoscopy. Anthropometric measures were taken, and blood was collected for serum protein analysis. Data were analyzed by logistic regression and factor analysis. Obese individuals (BMI >30) were 7.8 (CI: 2.3-26.3) times more likely than normal weight (BMI <25) individuals to have diverticulosis. The relationship was similar for waist circumference. Individuals with a waist circumference >45 inches were 8.1 (CI: 2.8-23.8) times more likely to have diverticulosis than those with a waist circumference <38 inches. Leptin was also positively associated with diverticulosis (OR = 5.5, CI: 2.0-14.7). Both low molecular weight adiponectin (LMW, OR = 0.50; CI: 0.3-0.8) and the soluble receptor for advanced glycation end products (sRAGE, OR = 0.4, CI: 0.3-0.7) were inversely related to the presence of diverticulosis. sRAGE levels were not correlated with leptin or C-peptide concentrations. The pattern of high BMI, waist circumference, leptin and C-peptide increased the odds of diverticulosis while the pattern of high levels of sRAGE and LMW adiponectin decreased the odds of diverticulosis. Associations between diverticulosis and anthropometric or serum markers may elucidate the origins of diverticulosis and may enable physicians to identify individuals at risk for diverticulitis.

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  • Authors+Show Affiliations

    ,

    Department of Food Science and Human Nutrition, Michigan State University, East Lansing, Michigan, United States of America.

    ,

    Department of Food Science and Human Nutrition, Michigan State University, East Lansing, Michigan, United States of America.

    ,

    Department of Epidemiology and Biostatistics, Michigan State University, East Lansing, Michigan, United States of America.

    ,

    College of Osteopathic Medicine, Michigan State University, East Lansing, Michigan, United States of America.

    ,

    College of Osteopathic Medicine, Michigan State University, East Lansing, Michigan, United States of America; Tri-County Gastroenterology, Professional Corporation, Clinton Township, Michigan, United States of America.

    Department of Food Science and Human Nutrition, Michigan State University, East Lansing, Michigan, United States of America; College of Osteopathic Medicine, Michigan State University, East Lansing, Michigan, United States of America.

    Source

    PloS one 9:4 2014 pg e95232

    MeSH

    Adiponectin
    Aged
    Anthropometry
    Asymptomatic Diseases
    Biomarkers
    Body Mass Index
    C-Peptide
    Colonoscopy
    Cross-Sectional Studies
    Diverticulum
    Factor Analysis, Statistical
    Humans
    Leptin
    Logistic Models
    Male
    Middle Aged
    Obesity
    Receptor for Advanced Glycation End Products
    Receptors, Immunologic
    Waist Circumference

    Pub Type(s)

    Journal Article
    Research Support, N.I.H., Extramural
    Research Support, Non-U.S. Gov't

    Language

    eng

    PubMed ID

    24740401

    Citation

    Comstock, Sarah S., et al. "Cross-sectional Analysis of Obesity and Serum Analytes in Males Identifies sRAGE as a Novel Biomarker Inversely Associated With Diverticulosis." PloS One, vol. 9, no. 4, 2014, pp. e95232.
    Comstock SS, Lewis MM, Pathak DR, et al. Cross-sectional analysis of obesity and serum analytes in males identifies sRAGE as a novel biomarker inversely associated with diverticulosis. PLoS ONE. 2014;9(4):e95232.
    Comstock, S. S., Lewis, M. M., Pathak, D. R., Hortos, K., Kovan, B., & Fenton, J. I. (2014). Cross-sectional analysis of obesity and serum analytes in males identifies sRAGE as a novel biomarker inversely associated with diverticulosis. PloS One, 9(4), pp. e95232. doi:10.1371/journal.pone.0095232.
    Comstock SS, et al. Cross-sectional Analysis of Obesity and Serum Analytes in Males Identifies sRAGE as a Novel Biomarker Inversely Associated With Diverticulosis. PLoS ONE. 2014;9(4):e95232. PubMed PMID: 24740401.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Cross-sectional analysis of obesity and serum analytes in males identifies sRAGE as a novel biomarker inversely associated with diverticulosis. AU - Comstock,Sarah S, AU - Lewis,Markita M, AU - Pathak,Dorothy R, AU - Hortos,Kari, AU - Kovan,Bruce, AU - Fenton,Jenifer I, Y1 - 2014/04/16/ PY - 2013/12/16/received PY - 2014/03/24/accepted PY - 2014/4/18/entrez PY - 2014/4/18/pubmed PY - 2015/6/2/medline SP - e95232 EP - e95232 JF - PloS one JO - PLoS ONE VL - 9 IS - 4 N2 - Diverticulosis can lead to diverticulitis, a colon condition involving inflammation and other complications. Diverticulosis can result from biological, behavioral, or genetic causes. However, the etiology of diverticulosis is unknown. Although diet is associated with diverticulosis, recent studies suggest other factors influence risk. We sought to identify anthropometric or serum markers that were associated with the presence of diverticulosis. To determine these associations, 126 asymptomatic men (48-65 yr) were recruited at the time of preventative screening colonoscopy. Anthropometric measures were taken, and blood was collected for serum protein analysis. Data were analyzed by logistic regression and factor analysis. Obese individuals (BMI >30) were 7.8 (CI: 2.3-26.3) times more likely than normal weight (BMI <25) individuals to have diverticulosis. The relationship was similar for waist circumference. Individuals with a waist circumference >45 inches were 8.1 (CI: 2.8-23.8) times more likely to have diverticulosis than those with a waist circumference <38 inches. Leptin was also positively associated with diverticulosis (OR = 5.5, CI: 2.0-14.7). Both low molecular weight adiponectin (LMW, OR = 0.50; CI: 0.3-0.8) and the soluble receptor for advanced glycation end products (sRAGE, OR = 0.4, CI: 0.3-0.7) were inversely related to the presence of diverticulosis. sRAGE levels were not correlated with leptin or C-peptide concentrations. The pattern of high BMI, waist circumference, leptin and C-peptide increased the odds of diverticulosis while the pattern of high levels of sRAGE and LMW adiponectin decreased the odds of diverticulosis. Associations between diverticulosis and anthropometric or serum markers may elucidate the origins of diverticulosis and may enable physicians to identify individuals at risk for diverticulitis. SN - 1932-6203 UR - https://www.unboundmedicine.com/medline/citation/24740401/full_citation L2 - http://dx.plos.org/10.1371/journal.pone.0095232 DB - PRIME DP - Unbound Medicine ER -