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Osteoarthritis, obesity and weight loss: evidence, hypotheses and horizons - a scoping review.

Abstract

Obesity is widely acknowledged as a risk factor for both the incidence and progression of osteoarthritis, and has a negative influence on outcomes. Loss of at least 10% of body weight, coupled with exercise, is recognized as a cornerstone in the management of obese patients with osteoarthritis, and can lead to significant improvement in symptoms, pain relief, physical function and health-related quality of life. However, questions still remain surrounding optimal management. Given the significant health, social and economic burden of osteoarthritis, especially in obese patients, it is imperative to advance our knowledge of osteoarthritis and obesity, and apply this to improving care and outcomes. This paper overviews what is already known about osteoarthritis and obesity, discusses current key challenges and ongoing hypotheses arising from research in these areas, and finally, postulates what the future may hold in terms of new horizons for obese patients with osteoarthritis.

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  • Authors+Show Affiliations

    ,

    The Parker Institute, Department of Rheumatology, Copenhagen University Hospital, Bispebjerg and Frederiksberg, Denmark.

    ,

    Source

    MeSH

    Diet, Reducing
    Disease Progression
    Humans
    Obesity
    Osteoarthritis
    Prevalence
    Quality of Life
    Risk Factors
    Weight Loss

    Pub Type(s)

    Journal Article
    Research Support, Non-U.S. Gov't
    Review

    Language

    eng

    PubMed ID

    24751192

    Citation

    Bliddal, H, et al. "Osteoarthritis, Obesity and Weight Loss: Evidence, Hypotheses and Horizons - a Scoping Review." Obesity Reviews : an Official Journal of the International Association for the Study of Obesity, vol. 15, no. 7, 2014, pp. 578-86.
    Bliddal H, Leeds AR, Christensen R. Osteoarthritis, obesity and weight loss: evidence, hypotheses and horizons - a scoping review. Obes Rev. 2014;15(7):578-86.
    Bliddal, H., Leeds, A. R., & Christensen, R. (2014). Osteoarthritis, obesity and weight loss: evidence, hypotheses and horizons - a scoping review. Obesity Reviews : an Official Journal of the International Association for the Study of Obesity, 15(7), pp. 578-86. doi:10.1111/obr.12173.
    Bliddal H, Leeds AR, Christensen R. Osteoarthritis, Obesity and Weight Loss: Evidence, Hypotheses and Horizons - a Scoping Review. Obes Rev. 2014;15(7):578-86. PubMed PMID: 24751192.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Osteoarthritis, obesity and weight loss: evidence, hypotheses and horizons - a scoping review. AU - Bliddal,H, AU - Leeds,A R, AU - Christensen,R, Y1 - 2014/04/22/ PY - 2013/12/20/received PY - 2014/01/10/revised PY - 2014/01/14/accepted PY - 2014/4/23/entrez PY - 2014/4/23/pubmed PY - 2015/3/31/medline KW - Obesity KW - osteoarthritis KW - treatment KW - weight loss SP - 578 EP - 86 JF - Obesity reviews : an official journal of the International Association for the Study of Obesity JO - Obes Rev VL - 15 IS - 7 N2 - Obesity is widely acknowledged as a risk factor for both the incidence and progression of osteoarthritis, and has a negative influence on outcomes. Loss of at least 10% of body weight, coupled with exercise, is recognized as a cornerstone in the management of obese patients with osteoarthritis, and can lead to significant improvement in symptoms, pain relief, physical function and health-related quality of life. However, questions still remain surrounding optimal management. Given the significant health, social and economic burden of osteoarthritis, especially in obese patients, it is imperative to advance our knowledge of osteoarthritis and obesity, and apply this to improving care and outcomes. This paper overviews what is already known about osteoarthritis and obesity, discusses current key challenges and ongoing hypotheses arising from research in these areas, and finally, postulates what the future may hold in terms of new horizons for obese patients with osteoarthritis. SN - 1467-789X UR - https://www.unboundmedicine.com/medline/citation/24751192/full_citation L2 - https://doi.org/10.1111/obr.12173 DB - PRIME DP - Unbound Medicine ER -