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Weight change in middle adulthood and breast cancer risk in the EPIC-PANACEA study.

Abstract

Long-term weight gain (i.e., weight gain since age 20) has been related to higher risk of postmenopausal breast cancer, but a lower risk of premenopausal breast cancer. The effect of weight change in middle adulthood is unclear. We investigated the association between weight change in middle adulthood (i.e., women aged 40-50 years) and the risk of breast cancer before and after the age of 50. We included female participants of the European Prospective Investigation into Cancer and Nutrition cohort, with information on anthropometric measures at recruitment and after a median follow-up of 4.3 years. Annual weight change was categorized using quintiles taking quintile 2 and 3 as the reference category (-0.44 to 0.36 kg/year). Multivariable Cox proportional hazards regression analysis was used to examine the association. 205,723 women were included and 4,663 incident breast cancer cases were diagnosed during a median follow-up of 7.5 years (from second weight assessment onward). High weight gain (Q5: 0.83-4.98 kg/year) was related to a slightly, but significantly higher breast cancer risk (HRQ5_versus_Q2/3 : 1.09, 95% CI: 1.01-1.18). The association was more pronounced for breast cancer diagnosed before or at age 50 (HRQ5_versus_Q2/3 : 1.37, 95% CI: 1.02-1.85). Weight loss was not associated with breast cancer risk. There was no evidence for heterogeneity by hormone receptor status. In conclusion, high weight gain in middle adulthood increases the risk of breast cancer. The association seems to be more pronounced for breast cancer diagnosed before or at age 50. Our results illustrate the importance of avoiding weight gain in middle adulthood.

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  • Authors+Show Affiliations

    ,

    Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht, the Netherlands.

    , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , ,

    Source

    International journal of cancer 135:12 2014 Dec 15 pg 2887-99

    MeSH

    Adult
    Body Weight
    Breast Neoplasms
    Europe
    Female
    Follow-Up Studies
    Humans
    Middle Aged
    Overweight
    Premenopause
    Proportional Hazards Models
    Prospective Studies
    Risk Factors
    Weight Gain

    Pub Type(s)

    Journal Article
    Research Support, Non-U.S. Gov't

    Language

    eng

    PubMed ID

    24771551

    Citation

    Emaus, Marleen J., et al. "Weight Change in Middle Adulthood and Breast Cancer Risk in the EPIC-PANACEA Study." International Journal of Cancer, vol. 135, no. 12, 2014, pp. 2887-99.
    Emaus MJ, van Gils CH, Bakker MF, et al. Weight change in middle adulthood and breast cancer risk in the EPIC-PANACEA study. Int J Cancer. 2014;135(12):2887-99.
    Emaus, M. J., van Gils, C. H., Bakker, M. F., Bisschop, C. N., Monninkhof, E. M., Bueno-de-Mesquita, H. B., ... May, A. M. (2014). Weight change in middle adulthood and breast cancer risk in the EPIC-PANACEA study. International Journal of Cancer, 135(12), pp. 2887-99. doi:10.1002/ijc.28926.
    Emaus MJ, et al. Weight Change in Middle Adulthood and Breast Cancer Risk in the EPIC-PANACEA Study. Int J Cancer. 2014 Dec 15;135(12):2887-99. PubMed PMID: 24771551.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Weight change in middle adulthood and breast cancer risk in the EPIC-PANACEA study. AU - Emaus,Marleen J, AU - van Gils,Carla H, AU - Bakker,Marije F, AU - Bisschop,Charlotte N Steins, AU - Monninkhof,Evelyn M, AU - Bueno-de-Mesquita,H B, AU - Travier,Noémie, AU - Berentzen,Tina Landsvig, AU - Overvad,Kim, AU - Tjønneland,Anne, AU - Romieu,Isabelle, AU - Rinaldi,Sabina, AU - Chajes,Veronique, AU - Gunter,Marc J, AU - Clavel-Chapelon,Françoise, AU - Fagherazzi,Guy, AU - Mesrine,Sylvie, AU - Chang-Claude,Jenny, AU - Kaaks,Rudolf, AU - Boeing,Heiner, AU - Aleksandrova,Krasimira, AU - Trichopoulou,Antonia, AU - Naska,Androniki, AU - Orfanos,Philippos, AU - Palli,Domenico, AU - Agnoli,Claudia, AU - Tumino,Rosario, AU - Vineis,Paolo, AU - Mattiello,Amalia, AU - Braaten,Tonje, AU - Borch,Kristin Benjaminsen, AU - Lund,Eiliv, AU - Menéndez,Virginia, AU - Sánchez,María-José, AU - Navarro,Carmen, AU - Barricarte,Aurelio, AU - Amiano,Pilar, AU - Sund,Malin, AU - Andersson,Anne, AU - Borgquist,Signe, AU - Olsson,Asa, AU - Khaw,Kay-Tee, AU - Wareham,Nick, AU - Travis,Ruth C, AU - Riboli,Elio, AU - Peeters,Petra H M, AU - May,Anne M, Y1 - 2014/05/16/ PY - 2014/01/13/received PY - 2014/03/20/accepted PY - 2014/4/29/entrez PY - 2014/4/29/pubmed PY - 2014/12/15/medline KW - adult weight gain KW - breast cancer KW - estrogen receptor KW - menopausal status KW - progesterone receptor SP - 2887 EP - 99 JF - International journal of cancer JO - Int. J. Cancer VL - 135 IS - 12 N2 - Long-term weight gain (i.e., weight gain since age 20) has been related to higher risk of postmenopausal breast cancer, but a lower risk of premenopausal breast cancer. The effect of weight change in middle adulthood is unclear. We investigated the association between weight change in middle adulthood (i.e., women aged 40-50 years) and the risk of breast cancer before and after the age of 50. We included female participants of the European Prospective Investigation into Cancer and Nutrition cohort, with information on anthropometric measures at recruitment and after a median follow-up of 4.3 years. Annual weight change was categorized using quintiles taking quintile 2 and 3 as the reference category (-0.44 to 0.36 kg/year). Multivariable Cox proportional hazards regression analysis was used to examine the association. 205,723 women were included and 4,663 incident breast cancer cases were diagnosed during a median follow-up of 7.5 years (from second weight assessment onward). High weight gain (Q5: 0.83-4.98 kg/year) was related to a slightly, but significantly higher breast cancer risk (HRQ5_versus_Q2/3 : 1.09, 95% CI: 1.01-1.18). The association was more pronounced for breast cancer diagnosed before or at age 50 (HRQ5_versus_Q2/3 : 1.37, 95% CI: 1.02-1.85). Weight loss was not associated with breast cancer risk. There was no evidence for heterogeneity by hormone receptor status. In conclusion, high weight gain in middle adulthood increases the risk of breast cancer. The association seems to be more pronounced for breast cancer diagnosed before or at age 50. Our results illustrate the importance of avoiding weight gain in middle adulthood. SN - 1097-0215 UR - https://www.unboundmedicine.com/medline/citation/24771551/full_citation L2 - https://doi.org/10.1002/ijc.28926 DB - PRIME DP - Unbound Medicine ER -