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Blood-brain barrier disruption: mechanistic links between Western diet consumption and dementia.

Abstract

Both obesity and Alzheimer's disease (AD) are major health burdens in Western societies. While commonly viewed as having separate etiologies, this review highlights data suggesting that intake of "Western diets", diets high in saturated fatty acids (SFA) and simple carbohydrates, may pose a common environmental risk factor contributing to the development of both of these adverse pathologies. We discuss the effects of Western Diet intake on learning and memory processes that are dependent on the hippocampus, as well as the importance of this brain region in both obesity development and the onset of Alzheimer's and other dementias. A putative mechanism is discussed that mechanistically links Western diet consumption, blood brain barrier (BBB) degradation, and subsequent hippocampal damage and dementia pathology.

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    Pub Type(s)

    REVIEW

    Language

    ENG

    PubMed ID

    24847262

    Citation

    TY - JOUR T1 - Blood-brain barrier disruption: mechanistic links between Western diet consumption and dementia. A1 - Hsu,Ted M, AU - Kanoski,Scott E, Y1 - 2014/5/09/ PY - 2014///ecollection PY - 2014/3/20/received PY - 2014/4/24/accepted PY - 2014/5/09/epublish PY - 2014/5/22/entrez PY - 2014/5/23/pubmed PY - 2014/5/23/medline KW - Alzheimer’s KW - Western diet KW - blood-brain barrier KW - cognitive impairment KW - hippocampus KW - obesity SP - 88 EP - 88 JF - Frontiers in aging neuroscience JO - Front Aging Neurosci VL - 6 N2 - Both obesity and Alzheimer's disease (AD) are major health burdens in Western societies. While commonly viewed as having separate etiologies, this review highlights data suggesting that intake of "Western diets", diets high in saturated fatty acids (SFA) and simple carbohydrates, may pose a common environmental risk factor contributing to the development of both of these adverse pathologies. We discuss the effects of Western Diet intake on learning and memory processes that are dependent on the hippocampus, as well as the importance of this brain region in both obesity development and the onset of Alzheimer's and other dementias. A putative mechanism is discussed that mechanistically links Western diet consumption, blood brain barrier (BBB) degradation, and subsequent hippocampal damage and dementia pathology. SN - 1663-4365 UR - https://www.unboundmedicine.com/medline/citation/24847262/full_citation L2 - http://dx.doi.org/10.3389/fnagi.2014.00088 ER -