Blood-brain barrier disruption: mechanistic links between Western diet consumption and dementia.
Front Aging Neurosci. 2014; 6:88.FA

Abstract

Both obesity and Alzheimer's disease (AD) are major health burdens in Western societies. While commonly viewed as having separate etiologies, this review highlights data suggesting that intake of "Western diets", diets high in saturated fatty acids (SFA) and simple carbohydrates, may pose a common environmental risk factor contributing to the development of both of these adverse pathologies. We discuss the effects of Western Diet intake on learning and memory processes that are dependent on the hippocampus, as well as the importance of this brain region in both obesity development and the onset of Alzheimer's and other dementias. A putative mechanism is discussed that mechanistically links Western diet consumption, blood brain barrier (BBB) degradation, and subsequent hippocampal damage and dementia pathology.

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Authors+Show Affiliations

Hsu TM

Neuroscience Graduate Program, University of Southern California Los Angeles, CA, USA.

Kanoski SE

Neuroscience Graduate Program, University of Southern California Los Angeles, CA, USA ; Department of Biological Sciences, University of Southern California Los Angeles, CA, USA.

Pub Type(s)

Journal Article

Review

Language

eng

PubMed ID

24847262

Citation

Hsu, Ted M., and Scott E. Kanoski. "Blood-brain Barrier Disruption: Mechanistic Links Between Western Diet Consumption and Dementia." Frontiers in Aging Neuroscience, vol. 6, 2014, p. 88.

Hsu TM, Kanoski SE. Blood-brain barrier disruption: mechanistic links between Western diet consumption and dementia. Front Aging Neurosci. 2014;6:88.

Hsu, T. M., & Kanoski, S. E. (2014). Blood-brain barrier disruption: mechanistic links between Western diet consumption and dementia. Frontiers in Aging Neuroscience, 6, 88. https://doi.org/10.3389/fnagi.2014.00088

Hsu TM, Kanoski SE. Blood-brain Barrier Disruption: Mechanistic Links Between Western Diet Consumption and Dementia. Front Aging Neurosci. 2014;6:88. PubMed PMID: 24847262.

* Article titles in AMA citation format should be in sentence-case

TY - JOUR T1 - Blood-brain barrier disruption: mechanistic links between Western diet consumption and dementia. AU - Hsu,Ted M, AU - Kanoski,Scott E, Y1 - 2014/05/09/ PY - 2014/03/20/received PY - 2014/04/24/accepted PY - 2014/5/22/entrez PY - 2014/5/23/pubmed PY - 2014/5/23/medline KW - Alzheimer’s KW - Western diet KW - blood-brain barrier KW - cognitive impairment KW - hippocampus KW - obesity SP - 88 EP - 88 JF - Frontiers in aging neuroscience JO - Front Aging Neurosci VL - 6 N2 - Both obesity and Alzheimer's disease (AD) are major health burdens in Western societies. While commonly viewed as having separate etiologies, this review highlights data suggesting that intake of "Western diets", diets high in saturated fatty acids (SFA) and simple carbohydrates, may pose a common environmental risk factor contributing to the development of both of these adverse pathologies. We discuss the effects of Western Diet intake on learning and memory processes that are dependent on the hippocampus, as well as the importance of this brain region in both obesity development and the onset of Alzheimer's and other dementias. A putative mechanism is discussed that mechanistically links Western diet consumption, blood brain barrier (BBB) degradation, and subsequent hippocampal damage and dementia pathology. SN - 1663-4365 UR - https://www.unboundmedicine.com/medline/citation/24847262/full_citation DB - PRIME DP - Unbound Medicine ER -

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Blood-brain barrier disruption: mechanistic links between Western diet consumption and dementia.Front Aging Neurosci. 2014; 6:88.FA