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Dairy foods intake and risk of Parkinson's disease: a dose-response meta-analysis of prospective cohort studies.

Abstract

Dairy foods have been linked to Parkinson's disease (PD), and a meta-analysis of prospective cohort studies on dairy foods intake and PD risk was conducted. Eligible studies were identified in a literature search of EMBASE and PubMed up to April 2014. Seven results from prospective studies were included, including 1,083 PD cases among 304,193 subjects. The combined risk of PD for highest vs. lowest level of dairy foods intake was 1.40 (1.20-1.63) overall, 1.66 (1.29-2.14) for men and 1.15 (0.85-1.56) for women. For highest vs. lowest level, the PD risk was 1.45 (1.23-1.73) for milk, 1.26 (0.99-1.60) for cheese, 0.95 (0.76-1.20) for yogurt and 0.76 (0.51-1.13) for butter. The linear dose-response relationship showed that PD risk increased by 17% [1.17 (1.06-1.30)] for every 200 g/day increment in milk intake (Pfor non-linearity = 0.22), and 13% [1.13 (0.91-1.40)] for every 10 g/day increment in cheese intake (Pfor non-linearity = 0.39). The absolute risk differences were estimated to be 2-4 PD cases per 100,000 person-years for every 200 g/day increment in milk intake, and 1-3 PD cases per 100,000 person-years for every 10 g/day increment in cheese intake. Dairy foods (milk, cheese) might be positively associated with increased risk of PD, especially for men.

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  • Publisher Full Text
  • Authors+Show Affiliations

    ,

    Department of Epidemiology and Health Statistics, Qingdao University Medical College, Dongzhou Road, No.38, Qingdao, 266021, Shandong, People's Republic of China, jiangwjqd@aliyun.com.

    , ,

    Source

    European journal of epidemiology 29:9 2014 Sep pg 613-9

    MeSH

    Animals
    Cheese
    Dairy Products
    Diet
    Dietary Fats
    Dose-Response Relationship, Drug
    Female
    Humans
    Male
    Middle Aged
    Milk
    Parkinson Disease
    Prospective Studies
    Questionnaires
    Risk Assessment
    Risk Factors
    Yogurt

    Pub Type(s)

    Journal Article
    Meta-Analysis
    Research Support, Non-U.S. Gov't

    Language

    eng

    PubMed ID

    24894826

    Citation

    TY - JOUR T1 - Dairy foods intake and risk of Parkinson's disease: a dose-response meta-analysis of prospective cohort studies. AU - Jiang,Wenjie, AU - Ju,Chuanxia, AU - Jiang,Hong, AU - Zhang,Dongfeng, Y1 - 2014/06/04/ PY - 2013/12/9/received PY - 2014/5/22/accepted PY - 2014/6/4/aheadofprint PY - 2014/6/5/entrez PY - 2014/6/5/pubmed PY - 2014/11/6/medline SP - 613 EP - 9 JF - European journal of epidemiology JO - Eur. J. Epidemiol. VL - 29 IS - 9 N2 - Dairy foods have been linked to Parkinson's disease (PD), and a meta-analysis of prospective cohort studies on dairy foods intake and PD risk was conducted. Eligible studies were identified in a literature search of EMBASE and PubMed up to April 2014. Seven results from prospective studies were included, including 1,083 PD cases among 304,193 subjects. The combined risk of PD for highest vs. lowest level of dairy foods intake was 1.40 (1.20-1.63) overall, 1.66 (1.29-2.14) for men and 1.15 (0.85-1.56) for women. For highest vs. lowest level, the PD risk was 1.45 (1.23-1.73) for milk, 1.26 (0.99-1.60) for cheese, 0.95 (0.76-1.20) for yogurt and 0.76 (0.51-1.13) for butter. The linear dose-response relationship showed that PD risk increased by 17% [1.17 (1.06-1.30)] for every 200 g/day increment in milk intake (Pfor non-linearity = 0.22), and 13% [1.13 (0.91-1.40)] for every 10 g/day increment in cheese intake (Pfor non-linearity = 0.39). The absolute risk differences were estimated to be 2-4 PD cases per 100,000 person-years for every 200 g/day increment in milk intake, and 1-3 PD cases per 100,000 person-years for every 10 g/day increment in cheese intake. Dairy foods (milk, cheese) might be positively associated with increased risk of PD, especially for men. SN - 1573-7284 UR - https://www.unboundmedicine.com/medline/citation/24894826/full_citation L2 - http://dx.doi.org/10.1007/s10654-014-9921-4 ER -