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Low-copper diet as a preventive strategy for Alzheimer's disease.
Neurobiol Aging 2014; 35 Suppl 2:S40-50NA

Abstract

Copper is an essential element, and either a copper deficiency or excess can be life threatening. Recent studies have indicated that alteration of copper metabolism is one of the pathogenetic mechanisms of Alzheimer's disease (AD). In light of these findings, many researchers have proposed preventive strategies to reduce AD risk. Because the general population comes in contact with copper mainly through dietary intake, that is, food 75% and drinking water 25%, a low-copper diet can reduce the risk of AD in individuals with an altered copper metabolism. We suggest that a diet-gene interplay is at the basis of the "copper phenotype" of sporadic AD. Herein, we describe the pathways regulating copper homeostasis, the adverse sequelae related to its derangements, the pathogenic mechanism of the AD copper phenotype, indications for a low-copper diet, and future perspectives to improve this preventive strategy.

Authors+Show Affiliations

Fatebenefratelli Foundation for Health Research and Education, AFaR Division, "San Giovanni Calibita" Fatebenefratelli Hospital, Rome, Italy; Laboratorio di Neurodegenerazione, IRCCS San Raffaele Pisana, Rome, Italy. Electronic address: rosanna.squitti@afar.it.Don Carlo Gnocchi Foundation ONLUS, Milan, Italy.Department of Biology, University of Rome "Tor Vergata", Rome, Italy.

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't
Review

Language

eng

PubMed ID

24913894

Citation

Squitti, Rosanna, et al. "Low-copper Diet as a Preventive Strategy for Alzheimer's Disease." Neurobiology of Aging, vol. 35 Suppl 2, 2014, pp. S40-50.
Squitti R, Siotto M, Polimanti R. Low-copper diet as a preventive strategy for Alzheimer's disease. Neurobiol Aging. 2014;35 Suppl 2:S40-50.
Squitti, R., Siotto, M., & Polimanti, R. (2014). Low-copper diet as a preventive strategy for Alzheimer's disease. Neurobiology of Aging, 35 Suppl 2, pp. S40-50. doi:10.1016/j.neurobiolaging.2014.02.031.
Squitti R, Siotto M, Polimanti R. Low-copper Diet as a Preventive Strategy for Alzheimer's Disease. Neurobiol Aging. 2014;35 Suppl 2:S40-50. PubMed PMID: 24913894.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Low-copper diet as a preventive strategy for Alzheimer's disease. AU - Squitti,Rosanna, AU - Siotto,Mariacristina, AU - Polimanti,Renato, Y1 - 2014/05/15/ PY - 2013/11/04/received PY - 2014/02/27/revised PY - 2014/02/27/accepted PY - 2014/6/11/entrez PY - 2014/6/11/pubmed PY - 2015/1/21/medline KW - Alzheimer's disease KW - Copper KW - Diet KW - Diet-gene interaction KW - Drinking water KW - Food KW - Genetics KW - Metabolism KW - Prevention KW - Susceptibility SP - S40 EP - 50 JF - Neurobiology of aging JO - Neurobiol. Aging VL - 35 Suppl 2 N2 - Copper is an essential element, and either a copper deficiency or excess can be life threatening. Recent studies have indicated that alteration of copper metabolism is one of the pathogenetic mechanisms of Alzheimer's disease (AD). In light of these findings, many researchers have proposed preventive strategies to reduce AD risk. Because the general population comes in contact with copper mainly through dietary intake, that is, food 75% and drinking water 25%, a low-copper diet can reduce the risk of AD in individuals with an altered copper metabolism. We suggest that a diet-gene interplay is at the basis of the "copper phenotype" of sporadic AD. Herein, we describe the pathways regulating copper homeostasis, the adverse sequelae related to its derangements, the pathogenic mechanism of the AD copper phenotype, indications for a low-copper diet, and future perspectives to improve this preventive strategy. SN - 1558-1497 UR - https://www.unboundmedicine.com/medline/citation/24913894/full_citation L2 - https://linkinghub.elsevier.com/retrieve/pii/S0197-4580(14)00359-5 DB - PRIME DP - Unbound Medicine ER -