Citation
Zanchetti, Alberto, et al. "Blood Pressure and Low-density Lipoprotein-cholesterol Lowering for Prevention of Strokes and Cognitive Decline: a Review of Available Trial Evidence." Journal of Hypertension, vol. 32, no. 9, 2014, pp. 1741-50.
Zanchetti A, Liu L, Mancia G, et al. Blood pressure and low-density lipoprotein-cholesterol lowering for prevention of strokes and cognitive decline: a review of available trial evidence. J Hypertens. 2014;32(9):1741-50.
Zanchetti, A., Liu, L., Mancia, G., Parati, G., Grassi, G., Stramba-Badiale, M., Silani, V., Bilo, G., Corrao, G., Zambon, A., Scotti, L., Zhang, X., Wang, H., Zhang, Y., Zhang, X., Guan, T. R., Berge, E., Redon, J., Narkiewicz, K., ... Ford, G. (2014). Blood pressure and low-density lipoprotein-cholesterol lowering for prevention of strokes and cognitive decline: a review of available trial evidence. Journal of Hypertension, 32(9), 1741-50. https://doi.org/10.1097/HJH.0000000000000253
Zanchetti A, et al. Blood Pressure and Low-density Lipoprotein-cholesterol Lowering for Prevention of Strokes and Cognitive Decline: a Review of Available Trial Evidence. J Hypertens. 2014;32(9):1741-50. PubMed PMID: 24979302.
TY - JOUR
T1 - Blood pressure and low-density lipoprotein-cholesterol lowering for prevention of strokes and cognitive decline: a review of available trial evidence.
AU - Zanchetti,Alberto,
AU - Liu,Lisheng,
AU - Mancia,Giuseppe,
AU - Parati,Gianfranco,
AU - Grassi,Guido,
AU - Stramba-Badiale,Marco,
AU - Silani,Vincenzo,
AU - Bilo,Grzegorz,
AU - Corrao,Giovanni,
AU - Zambon,Antonella,
AU - Scotti,Lorenza,
AU - Zhang,Xinhua,
AU - Wang,HayYan,
AU - Zhang,Yuqing,
AU - Zhang,Xuezhong,
AU - Guan,Ting Rui,
AU - Berge,Eivind,
AU - Redon,Josep,
AU - Narkiewicz,Krzysztof,
AU - Dominiczak,Anna,
AU - Nilsson,Peter,
AU - Viigimaa,Margus,
AU - Laurent,Stéphane,
AU - Agabiti-Rosei,Enrico,
AU - Wu,Zhaosu,
AU - Zhu,Dingliang,
AU - Rodicio,José Luis,
AU - Ruilope,Luis Miguel,
AU - Martell-Claros,Nieves,
AU - Pinto,Fernando,
AU - Schmieder,Roland E,
AU - Burnier,Michel,
AU - Banach,Maciej,
AU - Cifkova,Renata,
AU - Farsang,Csaba,
AU - Konradi,Alexandra,
AU - Lazareva,Irina,
AU - Sirenko,Yuriy,
AU - Dorobantu,Maria,
AU - Postadzhiyan,Arman,
AU - Accetto,Rok,
AU - Jelakovic,Bojan,
AU - Lovic,Dragan,
AU - Manolis,Athanasios J,
AU - Stylianou,Philippos,
AU - Erdine,Serap,
AU - Dicker,Dror,
AU - Wei,Gangzhi,
AU - Xu,Chengbin,
AU - Xie,Hengge,
AU - Coca,Antonio,
AU - O'Brien,John,
AU - Ford,Gary,
PY - 2014/7/1/entrez
PY - 2014/7/1/pubmed
PY - 2015/11/17/medline
SP - 1741
EP - 50
JF - Journal of hypertension
JO - J Hypertens
VL - 32
IS - 9
N2 - BACKGROUND AND OBJECTIVES: It is well established by a large number of randomized controlled trials that lowering blood pressure (BP) and low-density lipoprotein cholesterol (LDL-C) by drugs are powerful means to reduce stroke incidence, but the optimal BP and LDL-C levels to be achieved are largely uncertain. Concerning BP targets, two hypotheses are being confronted: first, the lower the BP, the better the treatment outcome, and second, the hypothesis that too low BP values are accompanied by a lower benefit and even higher risk. It is also unknown whether BP lowering and LDL-C lowering have additive beneficial effects for the primary and secondary prevention of stroke, and whether these treatments can prevent cognitive decline after stroke. RESULTS: A review of existing data from randomized controlled trials confirms that solid evidence on optimal BP and LDL-C targets is missing, possible interactions between BP and LDL-C lowering treatments have never been directly investigated, and evidence in favour of a beneficial effect of BP or LDL-C lowering on cognitive decline is, at best, very weak. CONCLUSION: A new, large randomized controlled trial is needed to determine the optimal level of BP and LDL-C for the prevention of recurrent stroke and cognitive decline.
SN - 1473-5598
UR - https://www.unboundmedicine.com/medline/citation/24979302/full_citation
DB - PRIME
DP - Unbound Medicine
ER -
