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Nutritional risk factors for age-related macular degeneration.

Abstract

PURPOSE

To evaluate the role of nutritional factors, serum lipids, and lipoproteins in late age-related macular degeneration (late AMD).

METHODS

Intake of red meat, fruit, fish, vegetables, and alcohol, smoking status, and body mass index (BMI) were ascertained questionnaire-based in 1147 late AMD cases and 1773 controls from the European Genetic Database. Serum levels of lipids and lipoproteins were determined. The relationship between nutritional factors and late AMD was assessed using logistic regression. Based on multivariate analysis, area-under-the-curve (AUC) was calculated by receiver-operating-characteristics (ROC).

RESULTS

In a multivariate analysis, besides age and smoking, obesity (odds ratio (OR): 1.44, P = 0.014) and red meat intake (daily: OR: 2.34, P = 8.22 × 10(-6); 2-6x/week: OR: 1.67, P = 7.98 × 10(-5)) were identified as risk factors for developing late AMD. Fruit intake showed a protective effect (daily: OR: 0.52, P = 0.005; 2-6x/week: OR: 0.58, P = 0.035). Serum lipid and lipoprotein levels showed no significant association with late AMD. ROC for nutritional factors, smoking, age, and BMI revealed an AUC of 0.781.

CONCLUSION

Red meat intake and obesity were independently associated with increased risk for late AMD, whereas fruit intake was protective. A better understanding of nutritional risk factors is necessary for the prevention of AMD.

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  • Authors+Show Affiliations

    ,

    Department of Ophthalmology, University Hospital of Cologne, Kerpener Straβe 62, 50924 Cologne, Germany.

    ,

    Department of Ophthalmology, University Hospital of Cologne, Kerpener Straβe 62, 50924 Cologne, Germany.

    ,

    Department of Ophthalmology, Radboud University Nijmegen Medical Center, Geert Grooteplein-Zuid 10, 6525 GA Nijmegen, The Netherlands.

    ,

    Institute of Medical Statistics, Informatics and Epidemiology, University of Cologne, Kerpener Straβe 62, 50924 Cologne, Germany.

    ,

    Department of Ophthalmology, Radboud University Nijmegen Medical Center, Geert Grooteplein-Zuid 10, 6525 GA Nijmegen, The Netherlands.

    ,

    Department of Ophthalmology, University Hospital of Cologne, Kerpener Straβe 62, 50924 Cologne, Germany.

    ,

    Department of Ophthalmology, Radboud University Nijmegen Medical Center, Geert Grooteplein-Zuid 10, 6525 GA Nijmegen, The Netherlands.

    Department of Ophthalmology, University Hospital of Cologne, Kerpener Straβe 62, 50924 Cologne, Germany.

    Source

    BioMed research international 2014: 2014 pg 413150

    MeSH

    Aged
    Aged, 80 and over
    Alcohol Drinking
    Animals
    Eating
    Female
    Fruit
    Humans
    Lipids
    Lipoproteins
    Macular Degeneration
    Male
    Meat
    Middle Aged
    Nutritional Physiological Phenomena
    Risk Factors
    Vegetables

    Pub Type(s)

    Journal Article
    Research Support, Non-U.S. Gov't

    Language

    eng

    PubMed ID

    25101280

    Citation

    Ersoy, Lebriz, et al. "Nutritional Risk Factors for Age-related Macular Degeneration." BioMed Research International, vol. 2014, 2014, p. 413150.
    Ersoy L, Ristau T, Lechanteur YT, et al. Nutritional risk factors for age-related macular degeneration. Biomed Res Int. 2014;2014:413150.
    Ersoy, L., Ristau, T., Lechanteur, Y. T., Hahn, M., Hoyng, C. B., Kirchhof, B., ... Fauser, S. (2014). Nutritional risk factors for age-related macular degeneration. BioMed Research International, 2014, p. 413150. doi:10.1155/2014/413150.
    Ersoy L, et al. Nutritional Risk Factors for Age-related Macular Degeneration. Biomed Res Int. 2014;2014:413150. PubMed PMID: 25101280.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Nutritional risk factors for age-related macular degeneration. AU - Ersoy,Lebriz, AU - Ristau,Tina, AU - Lechanteur,Yara T, AU - Hahn,Moritz, AU - Hoyng,Carel B, AU - Kirchhof,Bernd, AU - den Hollander,Anneke I, AU - Fauser,Sascha, Y1 - 2014/07/03/ PY - 2014/04/08/received PY - 2014/06/16/accepted PY - 2014/8/8/entrez PY - 2014/8/8/pubmed PY - 2015/4/15/medline SP - 413150 EP - 413150 JF - BioMed research international JO - Biomed Res Int VL - 2014 N2 - PURPOSE: To evaluate the role of nutritional factors, serum lipids, and lipoproteins in late age-related macular degeneration (late AMD). METHODS: Intake of red meat, fruit, fish, vegetables, and alcohol, smoking status, and body mass index (BMI) were ascertained questionnaire-based in 1147 late AMD cases and 1773 controls from the European Genetic Database. Serum levels of lipids and lipoproteins were determined. The relationship between nutritional factors and late AMD was assessed using logistic regression. Based on multivariate analysis, area-under-the-curve (AUC) was calculated by receiver-operating-characteristics (ROC). RESULTS: In a multivariate analysis, besides age and smoking, obesity (odds ratio (OR): 1.44, P = 0.014) and red meat intake (daily: OR: 2.34, P = 8.22 × 10(-6); 2-6x/week: OR: 1.67, P = 7.98 × 10(-5)) were identified as risk factors for developing late AMD. Fruit intake showed a protective effect (daily: OR: 0.52, P = 0.005; 2-6x/week: OR: 0.58, P = 0.035). Serum lipid and lipoprotein levels showed no significant association with late AMD. ROC for nutritional factors, smoking, age, and BMI revealed an AUC of 0.781. CONCLUSION: Red meat intake and obesity were independently associated with increased risk for late AMD, whereas fruit intake was protective. A better understanding of nutritional risk factors is necessary for the prevention of AMD. SN - 2314-6141 UR - https://www.unboundmedicine.com/medline/citation/25101280/full_citation L2 - https://dx.doi.org/10.1155/2014/413150 DB - PRIME DP - Unbound Medicine ER -