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The mTOR signalling pathway in cancer and the potential mTOR inhibitory activities of natural phytochemicals.

Abstract

The mammalian target of rapamycin (mTOR) kinase plays an important role in regulating cell growth and cell cycle progression in response to cellular signals. It is a key regulator of cell proliferation and many upstream activators and downstream effectors of mTOR are known to be deregulated in various types of cancers. Since the mTOR signalling pathway is commonly activated in human cancers, many researchers are actively developing inhibitors that target key components in the pathway and some of these drugs are already on the market. Numerous preclinical investigations have also suggested that some herbs and natural phytochemicals, such as curcumin, resveratrol, timosaponin III, gallic acid, diosgenin, pomegranate, epigallocatechin gallate (EGCC), genistein and 3,3'-diindolylmethane inhibit the mTOR pathway either directly or indirectly. Some of these natural compounds are also in the clinical trial stage. In this review, the potential anti-cancer and chemopreventive activities and the current status of clinical trials of these phytochemicals are discussed.

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  • Authors+Show Affiliations

    ,

    Malaysian Institute of Pharmaceuticals and Nutraceuticals, Ministry of Science, Technology and Innovation (MOSTI), Halaman Bukit Gambir, Malaysia E-mail : tanml@usm.my, drtanmelan@yahoo.com.

    ,

    Source

    MeSH

    Antineoplastic Agents
    Cell Cycle
    Cell Proliferation
    Humans
    Mechanistic Target of Rapamycin Complex 1
    Mechanistic Target of Rapamycin Complex 2
    Multiprotein Complexes
    Neoplasms
    Phosphatidylinositol 3-Kinases
    Phytochemicals
    Phytotherapy
    Proto-Oncogene Proteins c-akt
    Signal Transduction
    TOR Serine-Threonine Kinases

    Pub Type(s)

    Journal Article
    Review

    Language

    eng

    PubMed ID

    25169472

    Citation

    Tan, Heng Kean, et al. "The mTOR Signalling Pathway in Cancer and the Potential mTOR Inhibitory Activities of Natural Phytochemicals." Asian Pacific Journal of Cancer Prevention : APJCP, vol. 15, no. 16, 2014, pp. 6463-75.
    Tan HK, Moad AI, Tan ML. The mTOR signalling pathway in cancer and the potential mTOR inhibitory activities of natural phytochemicals. Asian Pac J Cancer Prev. 2014;15(16):6463-75.
    Tan, H. K., Moad, A. I., & Tan, M. L. (2014). The mTOR signalling pathway in cancer and the potential mTOR inhibitory activities of natural phytochemicals. Asian Pacific Journal of Cancer Prevention : APJCP, 15(16), pp. 6463-75.
    Tan HK, Moad AI, Tan ML. The mTOR Signalling Pathway in Cancer and the Potential mTOR Inhibitory Activities of Natural Phytochemicals. Asian Pac J Cancer Prev. 2014;15(16):6463-75. PubMed PMID: 25169472.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - The mTOR signalling pathway in cancer and the potential mTOR inhibitory activities of natural phytochemicals. AU - Tan,Heng Kean, AU - Moad,Ahmed Ismail Hassan, AU - Tan,Mei Lan, PY - 2014/8/30/entrez PY - 2014/8/30/pubmed PY - 2015/6/9/medline SP - 6463 EP - 75 JF - Asian Pacific journal of cancer prevention : APJCP JO - Asian Pac. J. Cancer Prev. VL - 15 IS - 16 N2 - The mammalian target of rapamycin (mTOR) kinase plays an important role in regulating cell growth and cell cycle progression in response to cellular signals. It is a key regulator of cell proliferation and many upstream activators and downstream effectors of mTOR are known to be deregulated in various types of cancers. Since the mTOR signalling pathway is commonly activated in human cancers, many researchers are actively developing inhibitors that target key components in the pathway and some of these drugs are already on the market. Numerous preclinical investigations have also suggested that some herbs and natural phytochemicals, such as curcumin, resveratrol, timosaponin III, gallic acid, diosgenin, pomegranate, epigallocatechin gallate (EGCC), genistein and 3,3'-diindolylmethane inhibit the mTOR pathway either directly or indirectly. Some of these natural compounds are also in the clinical trial stage. In this review, the potential anti-cancer and chemopreventive activities and the current status of clinical trials of these phytochemicals are discussed. SN - 2476-762X UR - https://www.unboundmedicine.com/medline/citation/25169472/full_citation L2 - http://journal.waocp.org/?sid=Entrez:PubMed&id=pmid:25169472&key=2014.15.16.6463 DB - PRIME DP - Unbound Medicine ER -