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Metabolic syndrome and risk of age-related macular degeneration.

Abstract

PURPOSE

To investigate the relationship between metabolic syndrome (MetS) and its components with the risk of early- and late-stage age-related macular degeneration (AMD).

METHODS

A prospective cohort of individuals aged older than or equal to 49 years were followed up over a period of 10 years in the Blue Mountains Eye Study, Australia. MetS components were measured at baseline (1992-1994), 5-year (1997-1999), and 10-year (2002-2004) follow-ups. Incident cases of early and late AMD were diagnosed using standard photographic grading of retinal images of 2,218 participants at risk. Mixed-effect logistic regression was conducted to explore the relationship between MetS (and its components) with subsequent development of early/late AMD.

RESULTS

Over the 10-year follow-up, early AMD developed in 12% and late AMD in 3% of participants at risk. Amongst subjects aged younger than or equal to 70 years, MetS was associated with the incidence of late AMD. Of the five MetS components, obesity, high glucose, and high triglyceride were associated with the increased incidence of late AMD during the 10-year follow-up. There was no evidence of effect of MetS and its components on the risk of early AMD.

CONCLUSION

Metabolic syndrome, obesity, high glucose, and high triglycerides were predictors of progression to late AMD. These data provide additional insights into the pathogenesis of AMD.

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  • Authors+Show Affiliations

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    *Saw Swee Hock School of Public Health, National University of Singapore, and National University Health System, Singapore, Singapore; †Department of Epidemiology, School of Health, Shiraz University of Medical Sciences, Shiraz, Iran; ‡Yong Loo Lin School of Medicine, National University of Singapore and National University Health System, Singapore, Singapore; §Singapore Eye Research Institute, Singapore National Eye Center, Singapore, Singapore; ¶Department of Ophthalmology, Yong Loo Lin School of Medicine, National University of Singapore and National University Health System, Singapore, Singapore; **Duke-NUS Graduate Medical School, Singapore, Singapore; ††Department of Medicine, Yong Loo Lin School of Medicine, National University of Singapore and National University Health System, Singapore, Singapore; ‡‡Department of Statistics and Applied Probability, National University of Singapore, Singapore, Singapore; and §§Center for Vision Research, University of Sydney, Sydney, Australia.

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    Source

    Retina (Philadelphia, Pa.) 35:3 2015 Mar pg 459-66

    MeSH

    Aged
    Aged, 80 and over
    Australia
    Dyslipidemias
    European Continental Ancestry Group
    Female
    Follow-Up Studies
    Humans
    Hyperglycemia
    Hypertension
    Macular Degeneration
    Male
    Metabolic Syndrome
    Middle Aged
    Obesity
    Prevalence
    Prospective Studies
    Risk Factors
    Surveys and Questionnaires

    Pub Type(s)

    Journal Article
    Research Support, Non-U.S. Gov't

    Language

    eng

    PubMed ID

    25207946

    Citation

    Ghaem Maralani, Haleh, et al. "Metabolic Syndrome and Risk of Age-related Macular Degeneration." Retina (Philadelphia, Pa.), vol. 35, no. 3, 2015, pp. 459-66.
    Ghaem Maralani H, Tai BC, Wong TY, et al. Metabolic syndrome and risk of age-related macular degeneration. Retina (Philadelphia, Pa). 2015;35(3):459-66.
    Ghaem Maralani, H., Tai, B. C., Wong, T. Y., Tai, E. S., Li, J., Wang, J. J., & Mitchell, P. (2015). Metabolic syndrome and risk of age-related macular degeneration. Retina (Philadelphia, Pa.), 35(3), pp. 459-66. doi:10.1097/IAE.0000000000000338.
    Ghaem Maralani H, et al. Metabolic Syndrome and Risk of Age-related Macular Degeneration. Retina (Philadelphia, Pa). 2015;35(3):459-66. PubMed PMID: 25207946.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Metabolic syndrome and risk of age-related macular degeneration. AU - Ghaem Maralani,Haleh, AU - Tai,Bee Choo, AU - Wong,Tien Y, AU - Tai,E Shyong, AU - Li,Jialiang, AU - Wang,Jie Jin, AU - Mitchell,Paul, PY - 2014/9/11/entrez PY - 2014/9/11/pubmed PY - 2015/8/27/medline SP - 459 EP - 66 JF - Retina (Philadelphia, Pa.) JO - Retina (Philadelphia, Pa.) VL - 35 IS - 3 N2 - PURPOSE: To investigate the relationship between metabolic syndrome (MetS) and its components with the risk of early- and late-stage age-related macular degeneration (AMD). METHODS: A prospective cohort of individuals aged older than or equal to 49 years were followed up over a period of 10 years in the Blue Mountains Eye Study, Australia. MetS components were measured at baseline (1992-1994), 5-year (1997-1999), and 10-year (2002-2004) follow-ups. Incident cases of early and late AMD were diagnosed using standard photographic grading of retinal images of 2,218 participants at risk. Mixed-effect logistic regression was conducted to explore the relationship between MetS (and its components) with subsequent development of early/late AMD. RESULTS: Over the 10-year follow-up, early AMD developed in 12% and late AMD in 3% of participants at risk. Amongst subjects aged younger than or equal to 70 years, MetS was associated with the incidence of late AMD. Of the five MetS components, obesity, high glucose, and high triglyceride were associated with the increased incidence of late AMD during the 10-year follow-up. There was no evidence of effect of MetS and its components on the risk of early AMD. CONCLUSION: Metabolic syndrome, obesity, high glucose, and high triglycerides were predictors of progression to late AMD. These data provide additional insights into the pathogenesis of AMD. SN - 1539-2864 UR - https://www.unboundmedicine.com/medline/citation/25207946/full_citation L2 - http://Insights.ovid.com/pubmed?pmid=25207946 DB - PRIME DP - Unbound Medicine ER -