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Lactose intolerance and risk of lung, breast and ovarian cancers: aetiological clues from a population-based study in Sweden.
Br J Cancer 2015; 112(1):149-52BJ

Abstract

BACKGROUND

Individuals with lactose intolerance are recommended to avoid milk or dairy products, which may affect the development of cancer.

METHODS

We identified individuals with lactose intolerance from several Swedish Registers linked to the Swedish Cancer Registry to calculate standardised incidence ratios (SIRs) for cancers in the breast, lung, and ovary.

RESULTS

A total of 22,788 individuals with lactose intolerance were identified, and their risks of lung (SIR=0.55), breast (SIR=0.79), and ovarian (SIR=0.61) cancers were significantly decreased. Cancer incidences in the siblings and parents of individuals with lactose intolerance were similar to those in the general population.

CONCLUSIONS

In this large cohort study, people with lactose intolerance, characterised by low consumption of milk and other dairy products, had decreased risks of lung, breast, and ovarian cancers, but the decreased risks were not found in their family members, suggesting that the protective effects against these cancers may be related to their specific dietary pattern.

Authors+Show Affiliations

Center for Primary Health Care Research, Lund University, Malmö, Sweden.1] Center for Primary Health Care Research, Lund University, Malmö, Sweden [2] Stanford Prevention Research Center, Stanford University School of Medicine, Stanford, CA, USA.1] Center for Primary Health Care Research, Lund University, Malmö, Sweden [2] Stanford Prevention Research Center, Stanford University School of Medicine, Stanford, CA, USA.

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

25314053

Citation

Ji, J, et al. "Lactose Intolerance and Risk of Lung, Breast and Ovarian Cancers: Aetiological Clues From a Population-based Study in Sweden." British Journal of Cancer, vol. 112, no. 1, 2015, pp. 149-52.
Ji J, Sundquist J, Sundquist K. Lactose intolerance and risk of lung, breast and ovarian cancers: aetiological clues from a population-based study in Sweden. Br J Cancer. 2015;112(1):149-52.
Ji, J., Sundquist, J., & Sundquist, K. (2015). Lactose intolerance and risk of lung, breast and ovarian cancers: aetiological clues from a population-based study in Sweden. British Journal of Cancer, 112(1), pp. 149-52. doi:10.1038/bjc.2014.544.
Ji J, Sundquist J, Sundquist K. Lactose Intolerance and Risk of Lung, Breast and Ovarian Cancers: Aetiological Clues From a Population-based Study in Sweden. Br J Cancer. 2015 Jan 6;112(1):149-52. PubMed PMID: 25314053.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Lactose intolerance and risk of lung, breast and ovarian cancers: aetiological clues from a population-based study in Sweden. AU - Ji,J, AU - Sundquist,J, AU - Sundquist,K, Y1 - 2014/10/14/ PY - 2014/05/19/received PY - 2014/09/14/revised PY - 2014/09/20/accepted PY - 2014/10/15/entrez PY - 2014/10/15/pubmed PY - 2015/4/24/medline SP - 149 EP - 52 JF - British journal of cancer JO - Br. J. Cancer VL - 112 IS - 1 N2 - BACKGROUND: Individuals with lactose intolerance are recommended to avoid milk or dairy products, which may affect the development of cancer. METHODS: We identified individuals with lactose intolerance from several Swedish Registers linked to the Swedish Cancer Registry to calculate standardised incidence ratios (SIRs) for cancers in the breast, lung, and ovary. RESULTS: A total of 22,788 individuals with lactose intolerance were identified, and their risks of lung (SIR=0.55), breast (SIR=0.79), and ovarian (SIR=0.61) cancers were significantly decreased. Cancer incidences in the siblings and parents of individuals with lactose intolerance were similar to those in the general population. CONCLUSIONS: In this large cohort study, people with lactose intolerance, characterised by low consumption of milk and other dairy products, had decreased risks of lung, breast, and ovarian cancers, but the decreased risks were not found in their family members, suggesting that the protective effects against these cancers may be related to their specific dietary pattern. SN - 1532-1827 UR - http://www.unboundmedicine.com/medline/citation/25314053/full_citation L2 - http://dx.doi.org/10.1038/bjc.2014.544 DB - PRIME DP - Unbound Medicine ER -