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Lactose intolerance and risk of lung, breast and ovarian cancers: aetiological clues from a population-based study in Sweden.

Abstract

BACKGROUND

Individuals with lactose intolerance are recommended to avoid milk or dairy products, which may affect the development of cancer.

METHODS

We identified individuals with lactose intolerance from several Swedish Registers linked to the Swedish Cancer Registry to calculate standardised incidence ratios (SIRs) for cancers in the breast, lung, and ovary.

RESULTS

A total of 22,788 individuals with lactose intolerance were identified, and their risks of lung (SIR=0.55), breast (SIR=0.79), and ovarian (SIR=0.61) cancers were significantly decreased. Cancer incidences in the siblings and parents of individuals with lactose intolerance were similar to those in the general population.

CONCLUSIONS

In this large cohort study, people with lactose intolerance, characterised by low consumption of milk and other dairy products, had decreased risks of lung, breast, and ovarian cancers, but the decreased risks were not found in their family members, suggesting that the protective effects against these cancers may be related to their specific dietary pattern.

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  • Authors+Show Affiliations

    ,

    Center for Primary Health Care Research, Lund University, Malmö, Sweden.

    ,

    1] Center for Primary Health Care Research, Lund University, Malmö, Sweden [2] Stanford Prevention Research Center, Stanford University School of Medicine, Stanford, CA, USA.

    1] Center for Primary Health Care Research, Lund University, Malmö, Sweden [2] Stanford Prevention Research Center, Stanford University School of Medicine, Stanford, CA, USA.

    Source

    British journal of cancer 112:1 2015 Jan 06 pg 149-52

    MeSH

    Adult
    Breast Neoplasms
    Cohort Studies
    Female
    Humans
    Lactose Intolerance
    Lung Neoplasms
    Male
    Ovarian Neoplasms
    Risk
    Sweden

    Pub Type(s)

    Journal Article
    Research Support, Non-U.S. Gov't

    Language

    eng

    PubMed ID

    25314053

    Citation

    Ji, J, et al. "Lactose Intolerance and Risk of Lung, Breast and Ovarian Cancers: Aetiological Clues From a Population-based Study in Sweden." British Journal of Cancer, vol. 112, no. 1, 2015, pp. 149-52.
    Ji J, Sundquist J, Sundquist K. Lactose intolerance and risk of lung, breast and ovarian cancers: aetiological clues from a population-based study in Sweden. Br J Cancer. 2015;112(1):149-52.
    Ji, J., Sundquist, J., & Sundquist, K. (2015). Lactose intolerance and risk of lung, breast and ovarian cancers: aetiological clues from a population-based study in Sweden. British Journal of Cancer, 112(1), pp. 149-52. doi:10.1038/bjc.2014.544.
    Ji J, Sundquist J, Sundquist K. Lactose Intolerance and Risk of Lung, Breast and Ovarian Cancers: Aetiological Clues From a Population-based Study in Sweden. Br J Cancer. 2015 Jan 6;112(1):149-52. PubMed PMID: 25314053.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Lactose intolerance and risk of lung, breast and ovarian cancers: aetiological clues from a population-based study in Sweden. AU - Ji,J, AU - Sundquist,J, AU - Sundquist,K, Y1 - 2014/10/14/ PY - 2014/05/19/received PY - 2014/09/14/revised PY - 2014/09/20/accepted PY - 2014/10/15/entrez PY - 2014/10/15/pubmed PY - 2015/4/24/medline SP - 149 EP - 52 JF - British journal of cancer JO - Br. J. Cancer VL - 112 IS - 1 N2 - BACKGROUND: Individuals with lactose intolerance are recommended to avoid milk or dairy products, which may affect the development of cancer. METHODS: We identified individuals with lactose intolerance from several Swedish Registers linked to the Swedish Cancer Registry to calculate standardised incidence ratios (SIRs) for cancers in the breast, lung, and ovary. RESULTS: A total of 22,788 individuals with lactose intolerance were identified, and their risks of lung (SIR=0.55), breast (SIR=0.79), and ovarian (SIR=0.61) cancers were significantly decreased. Cancer incidences in the siblings and parents of individuals with lactose intolerance were similar to those in the general population. CONCLUSIONS: In this large cohort study, people with lactose intolerance, characterised by low consumption of milk and other dairy products, had decreased risks of lung, breast, and ovarian cancers, but the decreased risks were not found in their family members, suggesting that the protective effects against these cancers may be related to their specific dietary pattern. SN - 1532-1827 UR - https://www.unboundmedicine.com/medline/citation/25314053/full_citation L2 - http://dx.doi.org/10.1038/bjc.2014.544 DB - PRIME DP - Unbound Medicine ER -