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Nutrition intervention for migraine: a randomized crossover trial.

Abstract

BACKGROUND

Limited evidence suggests that dietary interventions may offer a promising approach for migraine. The purpose of this study was to determine the effects of a low-fat plant-based diet intervention on migraine severity and frequency.

METHODS

Forty-two adult migraine sufferers were recruited from the general community in Washington, DC, and divided randomly into two groups. This 36-week crossover study included two treatments: dietary instruction and placebo supplement. Each treatment period was 16 weeks, with a 4-week washout between. During the diet period, a low-fat vegan diet was prescribed for 4 weeks, after which an elimination diet was used. Participants were assessed at the beginning, midpoint, and end of each period. Significance was determined using student's t-tests.

RESULTS

Worst headache pain in last 2 weeks, as measured by visual analog scale, was initially 6.4/10 cm (SD 2.1 cm), and declined 2.1 cm during the diet period and 0.7 cm during the supplement period (p=0.03). Average headache intensity (0-10 scale) was initially 4.2 (SD 1.4) per week, and this declined by 1.0 during the diet period and by 0.5 during the supplement period (p=0.20). Average headache frequency was initially 2.3 (SD 1.8) per week, and this declined by 0.3 during the diet period and by 0.4 during the supplement period (p=0.61). The Patient's Global Impression of Change showed greater improvement in pain during the diet period (p<0.001).

CONCLUSIONS

These results suggest that a nutritional approach may be a useful part of migraine treatment, but that methodologic issues necessitate further research.

TRIAL REGISTRATION

Clinicaltrials.gov, NCT01699009 and NCT01547494.

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  • Authors+Show Affiliations

    ,

    Physicians Committee for Responsible Medicine, 5100 Wisconsin Ave, NW, Suite 400, Washington, DC 20016, USA. abunner@pcrm.org.

    , , ,

    Source

    The journal of headache and pain 15: 2014 Oct 23 pg 69

    MeSH

    Adult
    Cross-Over Studies
    Diet, Fat-Restricted
    Diet, Vegetarian
    Double-Blind Method
    Female
    Humans
    Male
    Middle Aged
    Migraine Disorders
    Pain Measurement
    Treatment Outcome

    Pub Type(s)

    Journal Article
    Randomized Controlled Trial
    Research Support, Non-U.S. Gov't

    Language

    eng

    PubMed ID

    25339342

    Citation

    Bunner, Anne E., et al. "Nutrition Intervention for Migraine: a Randomized Crossover Trial." The Journal of Headache and Pain, vol. 15, 2014, p. 69.
    Bunner AE, Agarwal U, Gonzales JF, et al. Nutrition intervention for migraine: a randomized crossover trial. J Headache Pain. 2014;15:69.
    Bunner, A. E., Agarwal, U., Gonzales, J. F., Valente, F., & Barnard, N. D. (2014). Nutrition intervention for migraine: a randomized crossover trial. The Journal of Headache and Pain, 15, p. 69. doi:10.1186/1129-2377-15-69.
    Bunner AE, et al. Nutrition Intervention for Migraine: a Randomized Crossover Trial. J Headache Pain. 2014 Oct 23;15:69. PubMed PMID: 25339342.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Nutrition intervention for migraine: a randomized crossover trial. AU - Bunner,Anne E, AU - Agarwal,Ulka, AU - Gonzales,Joseph F, AU - Valente,Francesca, AU - Barnard,Neal D, Y1 - 2014/10/23/ PY - 2014/08/18/received PY - 2014/10/03/accepted PY - 2014/10/24/entrez PY - 2014/10/24/pubmed PY - 2015/7/23/medline SP - 69 EP - 69 JF - The journal of headache and pain JO - J Headache Pain VL - 15 N2 - BACKGROUND: Limited evidence suggests that dietary interventions may offer a promising approach for migraine. The purpose of this study was to determine the effects of a low-fat plant-based diet intervention on migraine severity and frequency. METHODS: Forty-two adult migraine sufferers were recruited from the general community in Washington, DC, and divided randomly into two groups. This 36-week crossover study included two treatments: dietary instruction and placebo supplement. Each treatment period was 16 weeks, with a 4-week washout between. During the diet period, a low-fat vegan diet was prescribed for 4 weeks, after which an elimination diet was used. Participants were assessed at the beginning, midpoint, and end of each period. Significance was determined using student's t-tests. RESULTS: Worst headache pain in last 2 weeks, as measured by visual analog scale, was initially 6.4/10 cm (SD 2.1 cm), and declined 2.1 cm during the diet period and 0.7 cm during the supplement period (p=0.03). Average headache intensity (0-10 scale) was initially 4.2 (SD 1.4) per week, and this declined by 1.0 during the diet period and by 0.5 during the supplement period (p=0.20). Average headache frequency was initially 2.3 (SD 1.8) per week, and this declined by 0.3 during the diet period and by 0.4 during the supplement period (p=0.61). The Patient's Global Impression of Change showed greater improvement in pain during the diet period (p<0.001). CONCLUSIONS: These results suggest that a nutritional approach may be a useful part of migraine treatment, but that methodologic issues necessitate further research. TRIAL REGISTRATION: Clinicaltrials.gov, NCT01699009 and NCT01547494. SN - 1129-2377 UR - https://www.unboundmedicine.com/medline/citation/25339342/full_citation L2 - https://thejournalofheadacheandpain.biomedcentral.com/articles/10.1186/1129-2377-15-69 DB - PRIME DP - Unbound Medicine ER -