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Phytoestrogen intake and risk of ovarian cancer: a meta- analysis of 10 observational studies.

Abstract

BACKGROUND

Epidemiology studies have shown an inconclusive relationship between phytoestrogen intake and ovarian cancer risk and there have been no relevant meta-analyses directly regarding this topic. The purpose of the present meta-analysis was therefore to investigate any association between phytoestrogen intake and ovarian cancer in detail.

MATERIALS AND METHODS

We conducted a search of PubMed, EMBASE, EBSCO, the Cochrane Library, CNKI and Chinese Biomedical Database (up to April 2014) using common keywords for studies that focused on phytoestrogen and ovarian cancer risk. Study-specific risk estimates (RRs) were pooled using fixed effect or random-effect models.

RESULTS

Ten epidemiologic studies were finally included in the meta-analysis. The total results indicated higher phytoestrogen intake was associated with a reduced ovarian cancer risk (RR, 0.70; 95%CI: 0.56-0.87). The association was similar in sensitivity analysis. Meta regression analysis demonstrated sources and possibly types and regions as heterogeneous factors. Subgroup analysis of types, sources and regions showed that isoflavones (RR: 0.63; 95%CI: 0.46, 0.86), soy foods (RR: 0.51; 95%CI: 0.39, 0.68) and an Asian diet (RR: 0.48; 95%CI: 0.37, 0.63) intake could reduce the incidence of ovarian cancer.

CONCLUSIONS

Our findings show possible protection by phytoestrogens against ovarian cancer. We emphasize specific phytoestrogens from soy foods, but not all could reduce the risk. The habit of plentiful phytoestrogen intake by Asians is worthy to recommendation. However, we still need additional larger well designed observational studies to fully characterize underlying associations.

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  • Authors+Show Affiliations

    ,

    The Reproductive Medicine Center, Zhongnan Hospital of Wuhan University, Wuhan, China E-mail : zhangyuanzhen@vip.sina.com.

    , ,

    Source

    MeSH

    China
    Diet
    Female
    Humans
    Incidence
    Observational Studies as Topic
    Ovarian Neoplasms
    Phytoestrogens
    Prognosis
    Risk Factors

    Pub Type(s)

    Journal Article
    Meta-Analysis
    Research Support, Non-U.S. Gov't

    Language

    eng

    PubMed ID

    25422183

    Citation

    Qu, Xin-Lan, et al. "Phytoestrogen Intake and Risk of Ovarian Cancer: a Meta- Analysis of 10 Observational Studies." Asian Pacific Journal of Cancer Prevention : APJCP, vol. 15, no. 21, 2014, pp. 9085-91.
    Qu XL, Fang Y, Zhang M, et al. Phytoestrogen intake and risk of ovarian cancer: a meta- analysis of 10 observational studies. Asian Pac J Cancer Prev. 2014;15(21):9085-91.
    Qu, X. L., Fang, Y., Zhang, M., & Zhang, Y. Z. (2014). Phytoestrogen intake and risk of ovarian cancer: a meta- analysis of 10 observational studies. Asian Pacific Journal of Cancer Prevention : APJCP, 15(21), pp. 9085-91.
    Qu XL, et al. Phytoestrogen Intake and Risk of Ovarian Cancer: a Meta- Analysis of 10 Observational Studies. Asian Pac J Cancer Prev. 2014;15(21):9085-91. PubMed PMID: 25422183.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Phytoestrogen intake and risk of ovarian cancer: a meta- analysis of 10 observational studies. AU - Qu,Xin-Lan, AU - Fang,Yuan, AU - Zhang,Ming, AU - Zhang,Yuan-Zhen, PY - 2014/11/26/entrez PY - 2014/11/26/pubmed PY - 2015/7/22/medline SP - 9085 EP - 91 JF - Asian Pacific journal of cancer prevention : APJCP JO - Asian Pac. J. Cancer Prev. VL - 15 IS - 21 N2 - BACKGROUND: Epidemiology studies have shown an inconclusive relationship between phytoestrogen intake and ovarian cancer risk and there have been no relevant meta-analyses directly regarding this topic. The purpose of the present meta-analysis was therefore to investigate any association between phytoestrogen intake and ovarian cancer in detail. MATERIALS AND METHODS: We conducted a search of PubMed, EMBASE, EBSCO, the Cochrane Library, CNKI and Chinese Biomedical Database (up to April 2014) using common keywords for studies that focused on phytoestrogen and ovarian cancer risk. Study-specific risk estimates (RRs) were pooled using fixed effect or random-effect models. RESULTS: Ten epidemiologic studies were finally included in the meta-analysis. The total results indicated higher phytoestrogen intake was associated with a reduced ovarian cancer risk (RR, 0.70; 95%CI: 0.56-0.87). The association was similar in sensitivity analysis. Meta regression analysis demonstrated sources and possibly types and regions as heterogeneous factors. Subgroup analysis of types, sources and regions showed that isoflavones (RR: 0.63; 95%CI: 0.46, 0.86), soy foods (RR: 0.51; 95%CI: 0.39, 0.68) and an Asian diet (RR: 0.48; 95%CI: 0.37, 0.63) intake could reduce the incidence of ovarian cancer. CONCLUSIONS: Our findings show possible protection by phytoestrogens against ovarian cancer. We emphasize specific phytoestrogens from soy foods, but not all could reduce the risk. The habit of plentiful phytoestrogen intake by Asians is worthy to recommendation. However, we still need additional larger well designed observational studies to fully characterize underlying associations. SN - 2476-762X UR - https://www.unboundmedicine.com/medline/citation/25422183/full_citation L2 - http://journal.waocp.org/?sid=Entrez:PubMed&id=pmid:25422183&key=2014.15.21.9085 DB - PRIME DP - Unbound Medicine ER -