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Alcohol consumption and site-specific cancer risk: a comprehensive dose-response meta-analysis.

Abstract

BACKGROUND

Alcohol is a risk factor for cancer of the oral cavity, pharynx, oesophagus, colorectum, liver, larynx and female breast, whereas its impact on other cancers remains controversial.

METHODS

We investigated the effect of alcohol on 23 cancer types through a meta-analytic approach. We used dose-response meta-regression models and investigated potential sources of heterogeneity.

RESULTS

A total of 572 studies, including 486 538 cancer cases, were identified. Relative risks (RRs) for heavy drinkers compared with nondrinkers and occasional drinkers were 5.13 for oral and pharyngeal cancer, 4.95 for oesophageal squamous cell carcinoma, 1.44 for colorectal, 2.65 for laryngeal and 1.61 for breast cancer; for those neoplasms there was a clear dose-risk relationship. Heavy drinkers also had a significantly higher risk of cancer of the stomach (RR 1.21), liver (2.07), gallbladder (2.64), pancreas (1.19) and lung (1.15). There was indication of a positive association between alcohol consumption and risk of melanoma and prostate cancer. Alcohol consumption and risk of Hodgkin's and Non-Hodgkin's lymphomas were inversely associated.

CONCLUSIONS

Alcohol increases risk of cancer of oral cavity and pharynx, oesophagus, colorectum, liver, larynx and female breast. There is accumulating evidence that alcohol drinking is associated with some other cancers such as pancreas and prostate cancer and melanoma.

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  • Authors+Show Affiliations

    ,

    1] Department of Statistics and Quantitative Methods, University of Milan-Bicocca, Via Bicocca degli Arcimboldi 8, 20126 Milan, Italy [2] Division of Epidemiology and Biostatistics, European Institute of Oncology, Via Ripamonti 435, 20141 Milan, Italy.

    ,

    1] Department of Health Sciences, Centre of Biostatistics for Clinical Epidemiology, University of Milan-Bicocca, Via Cadore 48, 20900 Monza, Italy [2] Department of Epidemiology, IRCCS Mario Negri Institute for Pharmacological Research, Via La Masa 19, 20156 Milan, Italy.

    ,

    Division of Epidemiology and Biostatistics, European Institute of Oncology, Via Ripamonti 435, 20141 Milan, Italy.

    ,

    Neurology, Besta Neurological Institute, Via Celoria 11, 20133 Milan, Italy.

    ,

    1] The Tisch Cancer Institute and Institute for Translational Epidemiology, Icahn School of Medicine at Mount Sinai, One Gustave L. Levy Place, New York, NY 10029-6574, USA [2] Digestive Disease Research Center, Shariati Hospital, Tehran University of Medical Science, Kargar Shomali Ave, 14117-13135 Tehran, I.R. Iran [3] Surveillance and Health Services Research, American Cancer Society, 250 Williams Street, Atlanta, GA 30303, USA.

    ,

    Department of Epidemiology, Rollins School of Public Health, Winship Cancer Institute, Emory University, 1518 Clifton Road, N.E., Atlanta, GA 30322, USA.

    ,

    Department of Statistics and Quantitative Methods, University of Milan-Bicocca, Via Bicocca degli Arcimboldi 8, 20126 Milan, Italy.

    ,

    Nutritional Epidemiology Group, International Agency for Research on Cancer, 150 Cours Albert-Thomas, 69008 Lyon, France.

    ,

    1] Department of Epidemiology, IRCCS Mario Negri Institute for Pharmacological Research, Via La Masa 19, 20156 Milan, Italy [2] Unit of Medical Statistics, Biometry and Bioinformatics, Fondazione IRCCS Istituto Nazionale Tumori, Via Vanzetti, 5 - 20133 Milan, Italy.

    ,

    Division of Epidemiology and Biostatistics, European Institute of Oncology, Via Ripamonti 435, 20141 Milan, Italy.

    ,

    Department of Epidemiology, IRCCS Mario Negri Institute for Pharmacological Research, Via La Masa 19, 20156 Milan, Italy.

    ,

    Department of Epidemiology, IRCCS Mario Negri Institute for Pharmacological Research, Via La Masa 19, 20156 Milan, Italy.

    ,

    1] Department of Statistics and Quantitative Methods, University of Milan-Bicocca, Via Bicocca degli Arcimboldi 8, 20126 Milan, Italy [2] Department of Medical Epidemiology and Biostatistics, Karolinska Institute, Box 281, Stockholm 171 77, Sweden.

    ,

    Department of Epidemiology, IRCCS Mario Negri Institute for Pharmacological Research, Via La Masa 19, 20156 Milan, Italy.

    ,

    Department of Statistics and Quantitative Methods, University of Milan-Bicocca, Via Bicocca degli Arcimboldi 8, 20126 Milan, Italy.

    ,

    The Tisch Cancer Institute and Institute for Translational Epidemiology, Icahn School of Medicine at Mount Sinai, One Gustave L. Levy Place, New York, NY 10029-6574, USA.

    Department of Clinical Sciences and Community Health, University of Milan, Via Vanzetti, 5 - 20133 Milan, Italy.

    Source

    British journal of cancer 112:3 2015 Feb 03 pg 580-93

    MeSH

    Alcohol Drinking
    Breast Neoplasms
    Carcinoma, Squamous Cell
    Case-Control Studies
    Dose-Response Relationship, Drug
    Esophageal Neoplasms
    Esophageal Squamous Cell Carcinoma
    Female
    Humans
    Incidence
    Male
    Melanoma
    Mouth Neoplasms
    Neoplasms
    Pharyngeal Neoplasms
    Prostatic Neoplasms
    Risk Factors

    Pub Type(s)

    Journal Article
    Meta-Analysis
    Research Support, Non-U.S. Gov't

    Language

    eng

    PubMed ID

    25422909

    Citation

    Bagnardi, V, et al. "Alcohol Consumption and Site-specific Cancer Risk: a Comprehensive Dose-response Meta-analysis." British Journal of Cancer, vol. 112, no. 3, 2015, pp. 580-93.
    Bagnardi V, Rota M, Botteri E, et al. Alcohol consumption and site-specific cancer risk: a comprehensive dose-response meta-analysis. Br J Cancer. 2015;112(3):580-93.
    Bagnardi, V., Rota, M., Botteri, E., Tramacere, I., Islami, F., Fedirko, V., ... La Vecchia, C. (2015). Alcohol consumption and site-specific cancer risk: a comprehensive dose-response meta-analysis. British Journal of Cancer, 112(3), pp. 580-93. doi:10.1038/bjc.2014.579.
    Bagnardi V, et al. Alcohol Consumption and Site-specific Cancer Risk: a Comprehensive Dose-response Meta-analysis. Br J Cancer. 2015 Feb 3;112(3):580-93. PubMed PMID: 25422909.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Alcohol consumption and site-specific cancer risk: a comprehensive dose-response meta-analysis. AU - Bagnardi,V, AU - Rota,M, AU - Botteri,E, AU - Tramacere,I, AU - Islami,F, AU - Fedirko,V, AU - Scotti,L, AU - Jenab,M, AU - Turati,F, AU - Pasquali,E, AU - Pelucchi,C, AU - Galeone,C, AU - Bellocco,R, AU - Negri,E, AU - Corrao,G, AU - Boffetta,P, AU - La Vecchia,C, Y1 - 2014/11/25/ PY - 2014/07/02/received PY - 2014/10/14/revised PY - 2014/10/18/accepted PY - 2014/11/26/entrez PY - 2014/11/26/pubmed PY - 2015/4/16/medline SP - 580 EP - 93 JF - British journal of cancer JO - Br. J. Cancer VL - 112 IS - 3 N2 - BACKGROUND: Alcohol is a risk factor for cancer of the oral cavity, pharynx, oesophagus, colorectum, liver, larynx and female breast, whereas its impact on other cancers remains controversial. METHODS: We investigated the effect of alcohol on 23 cancer types through a meta-analytic approach. We used dose-response meta-regression models and investigated potential sources of heterogeneity. RESULTS: A total of 572 studies, including 486 538 cancer cases, were identified. Relative risks (RRs) for heavy drinkers compared with nondrinkers and occasional drinkers were 5.13 for oral and pharyngeal cancer, 4.95 for oesophageal squamous cell carcinoma, 1.44 for colorectal, 2.65 for laryngeal and 1.61 for breast cancer; for those neoplasms there was a clear dose-risk relationship. Heavy drinkers also had a significantly higher risk of cancer of the stomach (RR 1.21), liver (2.07), gallbladder (2.64), pancreas (1.19) and lung (1.15). There was indication of a positive association between alcohol consumption and risk of melanoma and prostate cancer. Alcohol consumption and risk of Hodgkin's and Non-Hodgkin's lymphomas were inversely associated. CONCLUSIONS: Alcohol increases risk of cancer of oral cavity and pharynx, oesophagus, colorectum, liver, larynx and female breast. There is accumulating evidence that alcohol drinking is associated with some other cancers such as pancreas and prostate cancer and melanoma. SN - 1532-1827 UR - https://www.unboundmedicine.com/medline/citation/25422909/full_citation L2 - http://dx.doi.org/10.1038/bjc.2014.579 DB - PRIME DP - Unbound Medicine ER -