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Role of hormones and blood lipids in the pathogenesis of acne vulgaris in non-obese, non-hirsute females.

Abstract

CONTEXT

Acne vulgaris (AV) is a common disease affecting all ages and ethnic groups. Androgens, skin and serum lipids, inflammatory signaling and regulatory neuropeptides seem to be involved in this multi-factorial process.

AIM

The aim of this work was to determine hormonal levels and lipid profile in non-obese, non-hirsute females with AV.

SUBJECTS AND METHODS

A total of 60 non-obese, non-hirsute female cases with different grades of AV and 60 age- and gender-matched healthy volunteers were included. Measurement of serum total and free testosterone, sex hormone binding globulin (SHBG), estradiol and progesterone and blood lipids was done during the luteal phase of the menstrual cycle.

RESULTS

Total testosterone, free testosterone (FT) and progesterone levels were significantly higher (P < 0.001 for all) while estradiol levels (P < 0.001) and SHBG (P < 0.01) were significantly lower in cases than controls. Total cholesterol and low density lipoprotein cholesterol (LDL-C) levels were significantly higher (P < 0.001 for both) while high density lipoprotein cholesterol (HDL-C) and apolipoprotein A-1 (ApoA-1) levels were significantly lower (P < 0.001 for both) in cases than controls. Higher values of FT (P = 0.03) and SHBG (P = 0.02) and lower values of estradiol (P = 0.04) levels were significantly in favor of severe acne. Higher values of cholesterol (P < 0.001) and LDL-C (P = 0.03) and lower values of HDL-C (P = 0.01) and ApoA-1 (P = 0.02) levels were significantly associated with severe acne.

CONCLUSION

Changes in hormone levels and lipid profile in non-obese and non-hirsute females with AV should be considered in disease pathogenesis and in treatment prescription of these patients.

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  • Authors+Show Affiliations

    ,

    Department of Dermatology, Andrology and STDs, Faculty of Medicine, Menoufiya University, Menoufiya, Egypt.

    ,

    Department of Medical Biochemistry, Faculty of Medicine, Menoufiya University, Menoufiya, Egypt.

    ,

    Department of Dermatology, Andrology and STDs, Faculty of Medicine, Menoufiya University, Menoufiya, Egypt.

    Department of Dermatology, Andrology and STDs, Faculty of Medicine, Menoufiya University, Menoufiya, Egypt.

    Source

    Indian dermatology online journal 5:Suppl 1 2014 Nov pg S9-S16

    Pub Type(s)

    Journal Article

    Language

    eng

    PubMed ID

    25506579

    Citation

    Bakry, Ola Ahmed, et al. "Role of Hormones and Blood Lipids in the Pathogenesis of Acne Vulgaris in Non-obese, Non-hirsute Females." Indian Dermatology Online Journal, vol. 5, no. Suppl 1, 2014, pp. S9-S16.
    Bakry OA, El Shazly RM, El Farargy SM, et al. Role of hormones and blood lipids in the pathogenesis of acne vulgaris in non-obese, non-hirsute females. Indian Dermatol Online J. 2014;5(Suppl 1):S9-S16.
    Bakry, O. A., El Shazly, R. M., El Farargy, S. M., & Kotb, D. (2014). Role of hormones and blood lipids in the pathogenesis of acne vulgaris in non-obese, non-hirsute females. Indian Dermatology Online Journal, 5(Suppl 1), pp. S9-S16. doi:10.4103/2229-5178.144506.
    Bakry OA, et al. Role of Hormones and Blood Lipids in the Pathogenesis of Acne Vulgaris in Non-obese, Non-hirsute Females. Indian Dermatol Online J. 2014;5(Suppl 1):S9-S16. PubMed PMID: 25506579.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Role of hormones and blood lipids in the pathogenesis of acne vulgaris in non-obese, non-hirsute females. AU - Bakry,Ola Ahmed, AU - El Shazly,Rania Mohamed Azmy, AU - El Farargy,Shawky Mahmoud, AU - Kotb,Dalia, PY - 2014/12/16/entrez PY - 2014/12/17/pubmed PY - 2014/12/17/medline KW - Acne vulgaris KW - female KW - hormones KW - lipid profile SP - S9 EP - S16 JF - Indian dermatology online journal JO - Indian Dermatol Online J VL - 5 IS - Suppl 1 N2 - CONTEXT: Acne vulgaris (AV) is a common disease affecting all ages and ethnic groups. Androgens, skin and serum lipids, inflammatory signaling and regulatory neuropeptides seem to be involved in this multi-factorial process. AIM: The aim of this work was to determine hormonal levels and lipid profile in non-obese, non-hirsute females with AV. SUBJECTS AND METHODS: A total of 60 non-obese, non-hirsute female cases with different grades of AV and 60 age- and gender-matched healthy volunteers were included. Measurement of serum total and free testosterone, sex hormone binding globulin (SHBG), estradiol and progesterone and blood lipids was done during the luteal phase of the menstrual cycle. RESULTS: Total testosterone, free testosterone (FT) and progesterone levels were significantly higher (P < 0.001 for all) while estradiol levels (P < 0.001) and SHBG (P < 0.01) were significantly lower in cases than controls. Total cholesterol and low density lipoprotein cholesterol (LDL-C) levels were significantly higher (P < 0.001 for both) while high density lipoprotein cholesterol (HDL-C) and apolipoprotein A-1 (ApoA-1) levels were significantly lower (P < 0.001 for both) in cases than controls. Higher values of FT (P = 0.03) and SHBG (P = 0.02) and lower values of estradiol (P = 0.04) levels were significantly in favor of severe acne. Higher values of cholesterol (P < 0.001) and LDL-C (P = 0.03) and lower values of HDL-C (P = 0.01) and ApoA-1 (P = 0.02) levels were significantly associated with severe acne. CONCLUSION: Changes in hormone levels and lipid profile in non-obese and non-hirsute females with AV should be considered in disease pathogenesis and in treatment prescription of these patients. SN - 2229-5178 UR - https://www.unboundmedicine.com/medline/citation/25506579/full_citation L2 - https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/25506579/ DB - PRIME DP - Unbound Medicine ER -