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Vitamin D is associated with degree of disability in patients with fully ambulatory relapsing-remitting multiple sclerosis.
Eur J Neurol 2015; 22(3):564-9EJ

Abstract

BACKGROUND AND PURPOSE

Vitamin D deficiency is a recognized risk factor for multiple sclerosis (MS) and is associated with increased disease activity. It has also been proposed that the lower the vitamin D levels are, the higher is the handicap.

METHODS

To refine the links between vitamin D insufficiency and disability in MS patients, a retrospective cohort analysis was performed including 181 patients prospectively followed without previous vitamin D supplementation, and age, gender, age at MS onset, MS type, MS activity, Expanded Disability Status Scale (EDSS) were analysed in correlation with plasma vitamin D levels.

RESULTS

Vitamin D levels were significantly higher in relapsing-remitting MS than in progressive forms of MS in multivariate analyses adjusted for age, ethnicity, gender, disease duration and season (P = 0.0487). Overall, there was a negative correlation between vitamin D level and EDSS score (P = 0.0001, r = -0.33). In relapsing-remitting MS, vitamin D levels were only correlated with disability scores for EDSS < 4 (P = 0.0012). Patients with >20 ng/ml of vitamin D were 2.78 times more likely to have an EDSS < 4 (P = 0.0011, 95% confidence interval 1.49-5.00).

CONCLUSION

Data support previous work suggesting that vitamin D deficiency is associated with higher risk of disability in MS. Vitamin D levels also correlated with the degree of disability in fully ambulatory patients with relapsing-remitting MS. These additional results support the pertinence of randomized controlled trials analysing the interest of an early vitamin D supplementation in MS patients to influence evolution of disability.

Authors+Show Affiliations

Neurology Department, CHRU Caremeau, Nîmes, France; Institut de Génomique Fonctionnelle, UMR5203, Université Montpellier 1 et 2, Montpellier, France.No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

25530281

Citation

Thouvenot, E, et al. "Vitamin D Is Associated With Degree of Disability in Patients With Fully Ambulatory Relapsing-remitting Multiple Sclerosis." European Journal of Neurology, vol. 22, no. 3, 2015, pp. 564-9.
Thouvenot E, Orsini M, Daures JP, et al. Vitamin D is associated with degree of disability in patients with fully ambulatory relapsing-remitting multiple sclerosis. Eur J Neurol. 2015;22(3):564-9.
Thouvenot, E., Orsini, M., Daures, J. P., & Camu, W. (2015). Vitamin D is associated with degree of disability in patients with fully ambulatory relapsing-remitting multiple sclerosis. European Journal of Neurology, 22(3), pp. 564-9. doi:10.1111/ene.12617.
Thouvenot E, et al. Vitamin D Is Associated With Degree of Disability in Patients With Fully Ambulatory Relapsing-remitting Multiple Sclerosis. Eur J Neurol. 2015;22(3):564-9. PubMed PMID: 25530281.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Vitamin D is associated with degree of disability in patients with fully ambulatory relapsing-remitting multiple sclerosis. AU - Thouvenot,E, AU - Orsini,M, AU - Daures,J-P, AU - Camu,W, Y1 - 2014/12/20/ PY - 2014/09/09/received PY - 2014/10/09/accepted PY - 2014/12/23/entrez PY - 2014/12/23/pubmed PY - 2015/12/15/medline KW - Expanded Disability Status Scale KW - disability KW - multiple sclerosis KW - multiple sclerosis severity score KW - vitamin D SP - 564 EP - 9 JF - European journal of neurology JO - Eur. J. Neurol. VL - 22 IS - 3 N2 - BACKGROUND AND PURPOSE: Vitamin D deficiency is a recognized risk factor for multiple sclerosis (MS) and is associated with increased disease activity. It has also been proposed that the lower the vitamin D levels are, the higher is the handicap. METHODS: To refine the links between vitamin D insufficiency and disability in MS patients, a retrospective cohort analysis was performed including 181 patients prospectively followed without previous vitamin D supplementation, and age, gender, age at MS onset, MS type, MS activity, Expanded Disability Status Scale (EDSS) were analysed in correlation with plasma vitamin D levels. RESULTS: Vitamin D levels were significantly higher in relapsing-remitting MS than in progressive forms of MS in multivariate analyses adjusted for age, ethnicity, gender, disease duration and season (P = 0.0487). Overall, there was a negative correlation between vitamin D level and EDSS score (P = 0.0001, r = -0.33). In relapsing-remitting MS, vitamin D levels were only correlated with disability scores for EDSS < 4 (P = 0.0012). Patients with >20 ng/ml of vitamin D were 2.78 times more likely to have an EDSS < 4 (P = 0.0011, 95% confidence interval 1.49-5.00). CONCLUSION: Data support previous work suggesting that vitamin D deficiency is associated with higher risk of disability in MS. Vitamin D levels also correlated with the degree of disability in fully ambulatory patients with relapsing-remitting MS. These additional results support the pertinence of randomized controlled trials analysing the interest of an early vitamin D supplementation in MS patients to influence evolution of disability. SN - 1468-1331 UR - https://www.unboundmedicine.com/medline/citation/25530281/full_citation L2 - https://doi.org/10.1111/ene.12617 DB - PRIME DP - Unbound Medicine ER -