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Red meat intake and risk of non-Hodgkin lymphoma: a meta-analysis.

Abstract

BACKGROUND

While the incidence of non-Hodgkins lymphoma (NHL) has been rising worldwide, the reasons remain undefined. Recent research has focused on effect of red andf processed meat intake as a risk factor, but with inconclusive results. We therefore conducted a meta-analysis of data published to date, to ascertain the overall association between intake and NHL.

MATERIALS AND METHODS

A published literature search was performed through Pubmed, Cochrane Library, Medline, and Science Citation Index Expanded databases for articles published in English. Pooled odds ratios (ORs) and 95% confidence intervals (95%CIs) were calculated using random or fixed effects models. Heterogeneity was assessed using Chi-square and I2 statistics. Dissemination bias was evaluated by funnel plot analysis.We performed a formal meta-analysis using summary measures from these studies.

RESULTS

In total, 11 published studies were included in the final analysis. The combined analysis revealed that there was significant association between the red meat and NHL risk (OR=1.10, 95%CI: 1.02 to 1.19, p=0.01). Additionally, there was showed significance association between processed red meat and NHL risk (OR=1.17, 95%CI: 1.06 to 1.29, p=0.001). In subgroup analysis, a statistical significant association was noted between diffuse large B-cell lymphoma (DLBCL) (OR=1.20, 95%CI: 1.04 to 2.37, P=0.01) and red meat intake.

CONCLUSIONS

In this meta-Analysis, there was evidence for association between consumption of red meat, or processed meat and risk of NHL, particularly with the DLBCL subtype in the red meat case.

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  • Authors+Show Affiliations

    ,

    Department of Biostatistics and Epidemiology, Research Center of Prevention and Epidemiology of Non-Communicable Disease, Faculty of Health, Shahid Sadoughi University of Medical Sciences, Yazd, Iran E-mail : Epidemiology2012@gmail.com.

    , ,

    Source

    MeSH

    Animals
    Cattle
    Feeding Behavior
    Food Handling
    Humans
    Leukemia, Lymphocytic, Chronic, B-Cell
    Lymphoma, Follicular
    Lymphoma, Large B-Cell, Diffuse
    Lymphoma, Non-Hodgkin
    Meat
    Meat Products
    Odds Ratio
    Risk Factors
    Swine

    Pub Type(s)

    Journal Article
    Meta-Analysis

    Language

    eng

    PubMed ID

    25556486

    Citation

    Fallahzadeh, Hosein, et al. "Red Meat Intake and Risk of non-Hodgkin Lymphoma: a Meta-analysis." Asian Pacific Journal of Cancer Prevention : APJCP, vol. 15, no. 23, 2014, pp. 10421-5.
    Fallahzadeh H, Cheraghi M, Amoori N, et al. Red meat intake and risk of non-Hodgkin lymphoma: a meta-analysis. Asian Pac J Cancer Prev. 2014;15(23):10421-5.
    Fallahzadeh, H., Cheraghi, M., Amoori, N., & Alaf, M. (2014). Red meat intake and risk of non-Hodgkin lymphoma: a meta-analysis. Asian Pacific Journal of Cancer Prevention : APJCP, 15(23), pp. 10421-5.
    Fallahzadeh H, et al. Red Meat Intake and Risk of non-Hodgkin Lymphoma: a Meta-analysis. Asian Pac J Cancer Prev. 2014;15(23):10421-5. PubMed PMID: 25556486.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Red meat intake and risk of non-Hodgkin lymphoma: a meta-analysis. AU - Fallahzadeh,Hosein, AU - Cheraghi,Maria, AU - Amoori,Neda, AU - Alaf,Mehrangiz, PY - 2015/1/6/entrez PY - 2015/1/6/pubmed PY - 2015/9/10/medline SP - 10421 EP - 5 JF - Asian Pacific journal of cancer prevention : APJCP JO - Asian Pac. J. Cancer Prev. VL - 15 IS - 23 N2 - BACKGROUND: While the incidence of non-Hodgkins lymphoma (NHL) has been rising worldwide, the reasons remain undefined. Recent research has focused on effect of red andf processed meat intake as a risk factor, but with inconclusive results. We therefore conducted a meta-analysis of data published to date, to ascertain the overall association between intake and NHL. MATERIALS AND METHODS: A published literature search was performed through Pubmed, Cochrane Library, Medline, and Science Citation Index Expanded databases for articles published in English. Pooled odds ratios (ORs) and 95% confidence intervals (95%CIs) were calculated using random or fixed effects models. Heterogeneity was assessed using Chi-square and I2 statistics. Dissemination bias was evaluated by funnel plot analysis.We performed a formal meta-analysis using summary measures from these studies. RESULTS: In total, 11 published studies were included in the final analysis. The combined analysis revealed that there was significant association between the red meat and NHL risk (OR=1.10, 95%CI: 1.02 to 1.19, p=0.01). Additionally, there was showed significance association between processed red meat and NHL risk (OR=1.17, 95%CI: 1.06 to 1.29, p=0.001). In subgroup analysis, a statistical significant association was noted between diffuse large B-cell lymphoma (DLBCL) (OR=1.20, 95%CI: 1.04 to 2.37, P=0.01) and red meat intake. CONCLUSIONS: In this meta-Analysis, there was evidence for association between consumption of red meat, or processed meat and risk of NHL, particularly with the DLBCL subtype in the red meat case. SN - 2476-762X UR - https://www.unboundmedicine.com/medline/citation/25556486/full_citation L2 - http://journal.waocp.org/?sid=Entrez:PubMed&id=pmid:25556486&key=2014.15.23.10421 DB - PRIME DP - Unbound Medicine ER -