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[Yimusake Tablet: safe and efficacious for premature ejaculation].
Zhonghua Nan Ke Xue 2014; 20(11):1029-34ZN

Abstract

OBJECTIVE

To objectively evaluate the efficacy and safety of Yimusake Tablet in the treatment of premature ejaculation (PE) through a multi-centered large-sample trial.

METHODS

We conducted a multi-centered, open, fixed-dose, and self-compared clinical trial among 300 patients with diagnosed PE. The trial lasted 12 weeks, including 4 weeks without any medication and 8 weeks of treatment with Yimusake Tablet, 2 pills (1 g) per night. We observed the intravaginal ejaculation latency time (IELT) before and after treatment, evaluated the safety of medication, and performed a questionnaire investigation on the patients' satisfaction.

RESULTS

Of the 300 PE patients, 288 accomplished the clinical trial. The patients ranged in age from 22 to 60 years, averaging at 31.6 years. The mean IELT of the patient was 62.5 seconds at baseline, 168.9 seconds after 4 weeks of treatment with Yimusake Tablet, and 222.2 seconds after 8 weeks of medication. Among the 157 patients with normal erectile function (IIEF >21), the mean IELT was 71.4 seconds before treatment, 147.4 seconds after 4 weeks of medication, and 172.5 seconds after 8 weeks of medication. The patients' satisfaction was significantly increased after treatment. Those complicated by mild to moderate erectile dysfunction achieved different degrees of improvement in the IIEF-5 score, with a mean increase of 3.8. Only a few patients experienced mild adverse events, including constipation, dry mouth, nose bleeding, abdominal pain, and lumbosacral pain, which were all relieved without drug withdrawal.

CONCLUSION

Yimusake Tablet is a safe and effective medicine for the treatment of PE.

Authors+Show Affiliations

Department of Urology, Peking University Third Hospital, Beijing, China.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Clinical Trial
Journal Article
Multicenter Study

Language

chi

PubMed ID

25577841

Citation

Zhao, Lian-ming, et al. "[Yimusake Tablet: Safe and Efficacious for Premature Ejaculation]." Zhonghua Nan Ke Xue = National Journal of Andrology, vol. 20, no. 11, 2014, pp. 1029-34.
Zhao LM, Jiang H, Hong K, et al. [Yimusake Tablet: safe and efficacious for premature ejaculation]. Zhonghua Nan Ke Xue. 2014;20(11):1029-34.
Zhao, L. M., Jiang, H., Hong, K., Li, F. B., Xu, J. X., Zhang, X. S., ... Ma, W. G. (2014). [Yimusake Tablet: safe and efficacious for premature ejaculation]. Zhonghua Nan Ke Xue = National Journal of Andrology, 20(11), pp. 1029-34.
Zhao LM, et al. [Yimusake Tablet: Safe and Efficacious for Premature Ejaculation]. Zhonghua Nan Ke Xue. 2014;20(11):1029-34. PubMed PMID: 25577841.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - [Yimusake Tablet: safe and efficacious for premature ejaculation]. AU - Zhao,Lian-ming, AU - Jiang,Hui, AU - Hong,Kai, AU - Li,Fu-biao, AU - Xu,Ji-xiu, AU - Zhang,Xiang-sheng, AU - Mao,Xiang-ming, AU - Zhou,Shao-hu, AU - Chen,Bin, AU - Chen Ming,, AU - Pu,Xiao-yong, AU - Zhu,Cheng-bin, AU - Yang,Guo-sheng, AU - Ma,Liang-hong, AU - Ma,Sheng-li, AU - Tu,Xiang-an, AU - Deng,Chun-hua, AU - Sun,Xiang-zhou, AU - Yao,You-sheng, AU - Zhang,Bin, AU - Lu,Yi, AU - Jia,Jin-ming, AU - Ma,Wei-guo, PY - 2015/1/13/entrez PY - 2015/1/13/pubmed PY - 2015/6/13/medline SP - 1029 EP - 34 JF - Zhonghua nan ke xue = National journal of andrology JO - Zhonghua Nan Ke Xue VL - 20 IS - 11 N2 - OBJECTIVE: To objectively evaluate the efficacy and safety of Yimusake Tablet in the treatment of premature ejaculation (PE) through a multi-centered large-sample trial. METHODS: We conducted a multi-centered, open, fixed-dose, and self-compared clinical trial among 300 patients with diagnosed PE. The trial lasted 12 weeks, including 4 weeks without any medication and 8 weeks of treatment with Yimusake Tablet, 2 pills (1 g) per night. We observed the intravaginal ejaculation latency time (IELT) before and after treatment, evaluated the safety of medication, and performed a questionnaire investigation on the patients' satisfaction. RESULTS: Of the 300 PE patients, 288 accomplished the clinical trial. The patients ranged in age from 22 to 60 years, averaging at 31.6 years. The mean IELT of the patient was 62.5 seconds at baseline, 168.9 seconds after 4 weeks of treatment with Yimusake Tablet, and 222.2 seconds after 8 weeks of medication. Among the 157 patients with normal erectile function (IIEF >21), the mean IELT was 71.4 seconds before treatment, 147.4 seconds after 4 weeks of medication, and 172.5 seconds after 8 weeks of medication. The patients' satisfaction was significantly increased after treatment. Those complicated by mild to moderate erectile dysfunction achieved different degrees of improvement in the IIEF-5 score, with a mean increase of 3.8. Only a few patients experienced mild adverse events, including constipation, dry mouth, nose bleeding, abdominal pain, and lumbosacral pain, which were all relieved without drug withdrawal. CONCLUSION: Yimusake Tablet is a safe and effective medicine for the treatment of PE. SN - 1009-3591 UR - https://www.unboundmedicine.com/medline/citation/25577841/[Yimusake_Tablet:_safe_and_efficacious_for_premature_ejaculation] L2 - https://medlineplus.gov/herbalmedicine.html DB - PRIME DP - Unbound Medicine ER -