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Dietary selenium in adjuvant therapy of viral and bacterial infections.

Abstract

Viral and bacterial infections are often associated with deficiencies in macronutrients and micronutrients, including the essential trace element selenium. In selenium deficiency, benign strains of Coxsackie and influenza viruses can mutate to highly pathogenic strains. Dietary supplementation to provide adequate or supranutritional selenium supply has been proposed to confer health benefits for patients suffering from some viral diseases, most notably with respect to HIV and influenza A virus (IAV) infections. In addition, selenium-containing multimicronutrient supplements improved several clinical and lifestyle variables in patients coinfected with HIV and Mycobacterium tuberculosis. Selenium status may affect the function of cells of both adaptive and innate immunity. Supranutritional selenium promotes proliferation and favors differentiation of naive CD4-positive T lymphocytes toward T helper 1 cells, thus supporting the acute cellular immune response, whereas excessive activation of the immune system and ensuing host tissue damage are counteracted through directing macrophages toward the M2 phenotype. This review provides an up-to-date overview on selenium in infectious diseases caused by viruses (e.g., HIV, IAV, hepatitis C virus, poliovirus, West Nile virus) and bacteria (e.g., M. tuberculosis, Helicobacter pylori). Data from epidemiologic studies and intervention trials, with selenium alone or in combination with other micronutrients, and animal experiments are discussed against the background of dietary selenium requirements to alter immune functions.

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  • Authors+Show Affiliations

    ,

    Institute of Biochemistry and Molecular Biology I and.

    ,

    Department of Zoology, College of Science, King Saud University, Riyadh, Saudi Arabia; and.

    ,

    Department of Zoology, College of Science, King Saud University, Riyadh, Saudi Arabia; and Department of Zoology and Entomology, Faculty of Science, Helwan University, Cairo, Egypt.

    ,

    Department of Biology, Heinrich-Heine-University Düsseldorf, Düsseldorf, Germany;

    Institute of Biochemistry and Molecular Biology I and Department of Zoology, College of Science, King Saud University, Riyadh, Saudi Arabia; and sies@uni-duesseldorf.de.

    Source

    MeSH

    Adjuvants, Immunologic
    Animals
    Bacterial Infections
    Dietary Supplements
    Humans
    Immune System
    Selenium
    Trace Elements
    Virus Diseases

    Pub Type(s)

    Journal Article
    Research Support, Non-U.S. Gov't
    Review

    Language

    eng

    PubMed ID

    25593145

    Citation

    Steinbrenner, Holger, et al. "Dietary Selenium in Adjuvant Therapy of Viral and Bacterial Infections." Advances in Nutrition (Bethesda, Md.), vol. 6, no. 1, 2015, pp. 73-82.
    Steinbrenner H, Al-Quraishy S, Dkhil MA, et al. Dietary selenium in adjuvant therapy of viral and bacterial infections. Adv Nutr. 2015;6(1):73-82.
    Steinbrenner, H., Al-Quraishy, S., Dkhil, M. A., Wunderlich, F., & Sies, H. (2015). Dietary selenium in adjuvant therapy of viral and bacterial infections. Advances in Nutrition (Bethesda, Md.), 6(1), pp. 73-82. doi:10.3945/an.114.007575.
    Steinbrenner H, et al. Dietary Selenium in Adjuvant Therapy of Viral and Bacterial Infections. Adv Nutr. 2015;6(1):73-82. PubMed PMID: 25593145.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Dietary selenium in adjuvant therapy of viral and bacterial infections. AU - Steinbrenner,Holger, AU - Al-Quraishy,Saleh, AU - Dkhil,Mohamed A, AU - Wunderlich,Frank, AU - Sies,Helmut, Y1 - 2015/01/15/ PY - 2015/1/17/entrez PY - 2015/1/17/pubmed PY - 2015/7/15/medline KW - AIDS KW - immunity KW - micronutrient KW - selenoprotein KW - supplementation SP - 73 EP - 82 JF - Advances in nutrition (Bethesda, Md.) JO - Adv Nutr VL - 6 IS - 1 N2 - Viral and bacterial infections are often associated with deficiencies in macronutrients and micronutrients, including the essential trace element selenium. In selenium deficiency, benign strains of Coxsackie and influenza viruses can mutate to highly pathogenic strains. Dietary supplementation to provide adequate or supranutritional selenium supply has been proposed to confer health benefits for patients suffering from some viral diseases, most notably with respect to HIV and influenza A virus (IAV) infections. In addition, selenium-containing multimicronutrient supplements improved several clinical and lifestyle variables in patients coinfected with HIV and Mycobacterium tuberculosis. Selenium status may affect the function of cells of both adaptive and innate immunity. Supranutritional selenium promotes proliferation and favors differentiation of naive CD4-positive T lymphocytes toward T helper 1 cells, thus supporting the acute cellular immune response, whereas excessive activation of the immune system and ensuing host tissue damage are counteracted through directing macrophages toward the M2 phenotype. This review provides an up-to-date overview on selenium in infectious diseases caused by viruses (e.g., HIV, IAV, hepatitis C virus, poliovirus, West Nile virus) and bacteria (e.g., M. tuberculosis, Helicobacter pylori). Data from epidemiologic studies and intervention trials, with selenium alone or in combination with other micronutrients, and animal experiments are discussed against the background of dietary selenium requirements to alter immune functions. SN - 2156-5376 UR - https://www.unboundmedicine.com/medline/citation/25593145/full_citation L2 - https://academic.oup.com/advances/article-lookup/doi/10.3945/an.114.007575 DB - PRIME DP - Unbound Medicine ER -