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Alcohol consumption and risk of heart failure: a dose-response meta-analysis of prospective studies.
Eur J Heart Fail 2015; 17(4):367-73EJ

Abstract

AIMS

The aim of this study was to conduct a meta-analysis of prospective studies assessing the relationship between alcohol consumption and risk of heart failure (HF).

METHODS AND RESULTS

We searched the PubMed database from inception to September 2014 and reviewed the reference list of relevant articles to identify prospective studies assessing the association between alcohol consumption and risk of HF. Study-specific relative risk (RR) estimates were combined using a random-effects meta-analysis. The meta-analysis included eight prospective studies, with a total of 202 378 participants and 6211 cases of HF. The pooled adjusted RRs of HF were 0.85 [95% confidence interval (CI) 0.78-0.93] for light to moderate alcohol consumption (<14 drinks/week) and 0.90 (95% CI 0.72-1.13) for high alcohol consumption (≥14 drinks/week) compared with non-drinkers. In a dose-response meta-analysis, we observed a non-linear relationship between alcohol consumption and risk of HF (P for non-linearity = 0.001). Compared with non-drinkers, the RRs (95% CI) across levels of alcohol consumption were 0.90 (0.84-0.96) for 3 drinks/week, 0.83 (0.73-0.95) for 7 drinks/week, 0.84 (0.72-0.98) for 10 drinks/week, 0.90 (0.73-1.10) for 14 drinks/week, and 1.07 (0.77-1.48) for 21 drinks/week.

CONCLUSION

Alcohol consumption in moderation is associated with a reduced risk of HF.

Authors+Show Affiliations

Unit of Nutritional Epidemiology, Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden.No affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Meta-Analysis
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

25598021

Citation

Larsson, Susanna C., et al. "Alcohol Consumption and Risk of Heart Failure: a Dose-response Meta-analysis of Prospective Studies." European Journal of Heart Failure, vol. 17, no. 4, 2015, pp. 367-73.
Larsson SC, Orsini N, Wolk A. Alcohol consumption and risk of heart failure: a dose-response meta-analysis of prospective studies. Eur J Heart Fail. 2015;17(4):367-73.
Larsson, S. C., Orsini, N., & Wolk, A. (2015). Alcohol consumption and risk of heart failure: a dose-response meta-analysis of prospective studies. European Journal of Heart Failure, 17(4), pp. 367-73. doi:10.1002/ejhf.228.
Larsson SC, Orsini N, Wolk A. Alcohol Consumption and Risk of Heart Failure: a Dose-response Meta-analysis of Prospective Studies. Eur J Heart Fail. 2015;17(4):367-73. PubMed PMID: 25598021.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Alcohol consumption and risk of heart failure: a dose-response meta-analysis of prospective studies. AU - Larsson,Susanna C, AU - Orsini,Nicola, AU - Wolk,Alicja, Y1 - 2015/01/19/ PY - 2014/11/10/received PY - 2014/12/11/revised PY - 2014/12/12/accepted PY - 2015/1/20/entrez PY - 2015/1/20/pubmed PY - 2016/1/13/medline KW - Alcohol consumption KW - Heart failure KW - Meta-analysis KW - Prospective studies KW - Risk factors SP - 367 EP - 73 JF - European journal of heart failure JO - Eur. J. Heart Fail. VL - 17 IS - 4 N2 - AIMS: The aim of this study was to conduct a meta-analysis of prospective studies assessing the relationship between alcohol consumption and risk of heart failure (HF). METHODS AND RESULTS: We searched the PubMed database from inception to September 2014 and reviewed the reference list of relevant articles to identify prospective studies assessing the association between alcohol consumption and risk of HF. Study-specific relative risk (RR) estimates were combined using a random-effects meta-analysis. The meta-analysis included eight prospective studies, with a total of 202 378 participants and 6211 cases of HF. The pooled adjusted RRs of HF were 0.85 [95% confidence interval (CI) 0.78-0.93] for light to moderate alcohol consumption (<14 drinks/week) and 0.90 (95% CI 0.72-1.13) for high alcohol consumption (≥14 drinks/week) compared with non-drinkers. In a dose-response meta-analysis, we observed a non-linear relationship between alcohol consumption and risk of HF (P for non-linearity = 0.001). Compared with non-drinkers, the RRs (95% CI) across levels of alcohol consumption were 0.90 (0.84-0.96) for 3 drinks/week, 0.83 (0.73-0.95) for 7 drinks/week, 0.84 (0.72-0.98) for 10 drinks/week, 0.90 (0.73-1.10) for 14 drinks/week, and 1.07 (0.77-1.48) for 21 drinks/week. CONCLUSION: Alcohol consumption in moderation is associated with a reduced risk of HF. SN - 1879-0844 UR - https://www.unboundmedicine.com/medline/citation/25598021/full_citation L2 - https://doi.org/10.1002/ejhf.228 DB - PRIME DP - Unbound Medicine ER -