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Recommended dairy product intake modulates circulating fatty acid profile in healthy adults: a multi-centre cross-over study.

Abstract

Dairy products are rich sources of an array of fatty acids (FA) that have been shown individually and in certain clusters to exert varying effects on cardiovascular health, for which the circulating lipid profile is a powerful biomarker. Whether the profile of these FA is reflected in blood upon short terms of intake, possibly contributing to the lipid-related health impacts of dairy products, remains to be fully established. The objectives of the present study were to assess a recommended dairy product consumption in relation to circulating FA and lipid profiles, and to evaluate certain FA in dairy fat as potential biomarkers of intake. In a free-living, multi-centre, cross-over design, 124 healthy individuals consumed 3 servings/d of commercial dairy (DAIRY; 1% fat milk, 1·5% fat yogurt and 34% fat cheese) or energy-equivalent control (CONTROL; fruit and vegetable juice, cashews and a cookie) products for 4 weeks each, separated by a 4-week washout period. Plasma FA and serum lipid profiles were assessed by standard methods at the end of each dietary phase. After 4 weeks of intake, plasma levels of FA pentadecanoic acid (15 : 0) and heptadecanoic acid (17 : 0) were higher (0·26 v. 0·22% and 0·42 v. 0·39% of the total identified FA, respectively) after the DAIRY phase than after the CONTROL phase (P< 0·0001). This was accompanied by a small but significant increase in serum LDL-cholesterol levels after the DAIRY phase compared with the CONTROL phase (+0·08 mmol/l; P= 0·04). In conclusion, intake of 3 servings/d of conventional dairy products may modify certain circulating FA and lipid profiles within 4 weeks, where 15 : 0 and 17 : 0 may be potential short-term biomarkers of intake.

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  • Authors+Show Affiliations

    ,

    Department of Human Nutritional Sciences,University of Manitoba,Winnipeg,MB,CanadaR3T 6C5.

    ,

    Institute of Nutrition and Functional Foods (INAF), Laval University,2440, Boulevard Hochelaga,Québec,QC,CanadaG1V 0A6.

    ,

    Institute of Nutrition and Functional Foods (INAF), Laval University,2440, Boulevard Hochelaga,Québec,QC,CanadaG1V 0A6.

    ,

    Institute of Nutrition and Functional Foods (INAF), Laval University,2440, Boulevard Hochelaga,Québec,QC,CanadaG1V 0A6.

    ,

    Institute of Nutrition and Functional Foods (INAF), Laval University,2440, Boulevard Hochelaga,Québec,QC,CanadaG1V 0A6.

    ,

    Department of Human Nutritional Sciences,University of Manitoba,Winnipeg,MB,CanadaR3T 6C5.

    Institute of Nutrition and Functional Foods (INAF), Laval University,2440, Boulevard Hochelaga,Québec,QC,CanadaG1V 0A6.

    Source

    The British journal of nutrition 113:3 2015 Feb 14 pg 435-44

    MeSH

    Adolescent
    Adult
    Aged
    Animals
    Biomarkers
    Cheese
    Cholesterol, LDL
    Cross-Over Studies
    Dairy Products
    Diet
    Energy Intake
    Fatty Acids
    Female
    Humans
    Lipids
    Male
    Middle Aged
    Milk
    Nutrition Policy
    Nutritional Physiological Phenomena
    Yogurt
    Young Adult

    Pub Type(s)

    Journal Article
    Multicenter Study
    Randomized Controlled Trial
    Research Support, Non-U.S. Gov't

    Language

    eng

    PubMed ID

    25609231

    Citation

    Abdullah, Mohammad M H., et al. "Recommended Dairy Product Intake Modulates Circulating Fatty Acid Profile in Healthy Adults: a Multi-centre Cross-over Study." The British Journal of Nutrition, vol. 113, no. 3, 2015, pp. 435-44.
    Abdullah MM, Cyr A, Lépine MC, et al. Recommended dairy product intake modulates circulating fatty acid profile in healthy adults: a multi-centre cross-over study. Br J Nutr. 2015;113(3):435-44.
    Abdullah, M. M., Cyr, A., Lépine, M. C., Labonté, M. È., Couture, P., Jones, P. J., & Lamarche, B. (2015). Recommended dairy product intake modulates circulating fatty acid profile in healthy adults: a multi-centre cross-over study. The British Journal of Nutrition, 113(3), pp. 435-44. doi:10.1017/S0007114514003894.
    Abdullah MM, et al. Recommended Dairy Product Intake Modulates Circulating Fatty Acid Profile in Healthy Adults: a Multi-centre Cross-over Study. Br J Nutr. 2015 Feb 14;113(3):435-44. PubMed PMID: 25609231.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Recommended dairy product intake modulates circulating fatty acid profile in healthy adults: a multi-centre cross-over study. AU - Abdullah,Mohammad M H, AU - Cyr,Audrey, AU - Lépine,Marie-Claude, AU - Labonté,Marie-Ève, AU - Couture,Patrick, AU - Jones,Peter J H, AU - Lamarche,Benoît, Y1 - 2015/01/22/ PY - 2015/1/23/entrez PY - 2015/1/23/pubmed PY - 2015/4/8/medline KW - CVD SP - 435 EP - 44 JF - The British journal of nutrition JO - Br. J. Nutr. VL - 113 IS - 3 N2 - Dairy products are rich sources of an array of fatty acids (FA) that have been shown individually and in certain clusters to exert varying effects on cardiovascular health, for which the circulating lipid profile is a powerful biomarker. Whether the profile of these FA is reflected in blood upon short terms of intake, possibly contributing to the lipid-related health impacts of dairy products, remains to be fully established. The objectives of the present study were to assess a recommended dairy product consumption in relation to circulating FA and lipid profiles, and to evaluate certain FA in dairy fat as potential biomarkers of intake. In a free-living, multi-centre, cross-over design, 124 healthy individuals consumed 3 servings/d of commercial dairy (DAIRY; 1% fat milk, 1·5% fat yogurt and 34% fat cheese) or energy-equivalent control (CONTROL; fruit and vegetable juice, cashews and a cookie) products for 4 weeks each, separated by a 4-week washout period. Plasma FA and serum lipid profiles were assessed by standard methods at the end of each dietary phase. After 4 weeks of intake, plasma levels of FA pentadecanoic acid (15 : 0) and heptadecanoic acid (17 : 0) were higher (0·26 v. 0·22% and 0·42 v. 0·39% of the total identified FA, respectively) after the DAIRY phase than after the CONTROL phase (P< 0·0001). This was accompanied by a small but significant increase in serum LDL-cholesterol levels after the DAIRY phase compared with the CONTROL phase (+0·08 mmol/l; P= 0·04). In conclusion, intake of 3 servings/d of conventional dairy products may modify certain circulating FA and lipid profiles within 4 weeks, where 15 : 0 and 17 : 0 may be potential short-term biomarkers of intake. SN - 1475-2662 UR - https://www.unboundmedicine.com/medline/citation/25609231/full_citation L2 - https://www.cambridge.org/core/product/identifier/S0007114514003894/type/journal_article DB - PRIME DP - Unbound Medicine ER -