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Diabetes, cardiovascular morbidity, and risk of age-related macular degeneration in a primary care population.

Abstract

PURPOSE

Age-related macular degeneration (AMD) is the most common cause of legal blindness in Western patients over 65 years of age. We aimed to establish the incidence of AMD, and the association of diabetes, and cardiovascular and eye diseases with the risk of AMD, in a large cohort of primary care patients in the United Kingdom.

METHODS

Using data from The Health Improvement Network database in the United Kingdom, all individuals with a first recorded diagnosis of AMD from 2004 to 2010 were identified (N = 10,516) and frequency-matched to 19,389 AMD-free individuals by age, sex, and calendar year of AMD occurrence. Logistic regression was used to examine comorbidities and risk factors for AMD.

RESULTS

The incidence of AMD was 18.08 (95% confidence interval [CI], 17.74-18.43) per 10,000 person-years. A positive association with AMD was observed for smoking, a high frequency of primary care visits, and referrals. Diabetes and use of antidiabetic drugs were associated with an increased risk of AMD. Prevalence of cardiovascular diseases among AMD patients was slightly higher than in controls, with a small increased risk of AMD among patients with myocardial infarction, heart failure, or hyperlipidemia. Positive associations were observed between prior eye diseases and risk of AMD, in particular for chorioretinal disorders.

CONCLUSIONS

The incidence of AMD in the United Kingdom is in line with previously reported incidence rates from population-based studies. The study suggests an association between diabetes, prior eye diseases, cardiovascular comorbidities and AMD risk, and a link between AMD and higher healthcare utilization.

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  • Publisher Full Text
  • Authors+Show Affiliations

    ,

    Bayer Healthcare Pharmaceuticals, Whippany, New Jersey, United States.

    ,

    Spanish Centre for Pharmacoepidemiologic Research (CEIFE), Madrid, Spain.

    ,

    Bayer Pharma AG, Berlin, Germany.

    Spanish Centre for Pharmacoepidemiologic Research (CEIFE), Madrid, Spain.

    Source

    MeSH

    Aged
    Aged, 80 and over
    Cardiovascular Diseases
    Cohort Studies
    Comorbidity
    Diabetes Mellitus, Type 2
    Female
    Health Surveys
    Humans
    Incidence
    Macular Degeneration
    Male
    Middle Aged
    Primary Health Care
    Risk
    United Kingdom

    Pub Type(s)

    Journal Article
    Research Support, Non-U.S. Gov't

    Language

    eng

    PubMed ID

    25670489

    Citation

    Vassilev, Zdravko P., et al. "Diabetes, Cardiovascular Morbidity, and Risk of Age-related Macular Degeneration in a Primary Care Population." Investigative Ophthalmology & Visual Science, vol. 56, no. 3, 2015, pp. 1585-92.
    Vassilev ZP, Ruigómez A, Soriano-Gabarró M, et al. Diabetes, cardiovascular morbidity, and risk of age-related macular degeneration in a primary care population. Invest Ophthalmol Vis Sci. 2015;56(3):1585-92.
    Vassilev, Z. P., Ruigómez, A., Soriano-Gabarró, M., & García Rodríguez, L. A. (2015). Diabetes, cardiovascular morbidity, and risk of age-related macular degeneration in a primary care population. Investigative Ophthalmology & Visual Science, 56(3), pp. 1585-92. doi:10.1167/iovs.14-16271.
    Vassilev ZP, et al. Diabetes, Cardiovascular Morbidity, and Risk of Age-related Macular Degeneration in a Primary Care Population. Invest Ophthalmol Vis Sci. 2015 Feb 10;56(3):1585-92. PubMed PMID: 25670489.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Diabetes, cardiovascular morbidity, and risk of age-related macular degeneration in a primary care population. AU - Vassilev,Zdravko P, AU - Ruigómez,Ana, AU - Soriano-Gabarró,Montse, AU - García Rodríguez,Luis A, Y1 - 2015/02/10/ PY - 2015/2/12/entrez PY - 2015/2/12/pubmed PY - 2015/9/4/medline KW - age-related macular degeneration KW - cardiovascular KW - diabetes KW - healthcare use SP - 1585 EP - 92 JF - Investigative ophthalmology & visual science JO - Invest. Ophthalmol. Vis. Sci. VL - 56 IS - 3 N2 - PURPOSE: Age-related macular degeneration (AMD) is the most common cause of legal blindness in Western patients over 65 years of age. We aimed to establish the incidence of AMD, and the association of diabetes, and cardiovascular and eye diseases with the risk of AMD, in a large cohort of primary care patients in the United Kingdom. METHODS: Using data from The Health Improvement Network database in the United Kingdom, all individuals with a first recorded diagnosis of AMD from 2004 to 2010 were identified (N = 10,516) and frequency-matched to 19,389 AMD-free individuals by age, sex, and calendar year of AMD occurrence. Logistic regression was used to examine comorbidities and risk factors for AMD. RESULTS: The incidence of AMD was 18.08 (95% confidence interval [CI], 17.74-18.43) per 10,000 person-years. A positive association with AMD was observed for smoking, a high frequency of primary care visits, and referrals. Diabetes and use of antidiabetic drugs were associated with an increased risk of AMD. Prevalence of cardiovascular diseases among AMD patients was slightly higher than in controls, with a small increased risk of AMD among patients with myocardial infarction, heart failure, or hyperlipidemia. Positive associations were observed between prior eye diseases and risk of AMD, in particular for chorioretinal disorders. CONCLUSIONS: The incidence of AMD in the United Kingdom is in line with previously reported incidence rates from population-based studies. The study suggests an association between diabetes, prior eye diseases, cardiovascular comorbidities and AMD risk, and a link between AMD and higher healthcare utilization. SN - 1552-5783 UR - https://www.unboundmedicine.com/medline/citation/25670489/full_citation L2 - http://iovs.arvojournals.org/article.aspx?doi=10.1167/iovs.14-16271 DB - PRIME DP - Unbound Medicine ER -