Tags

Type your tag names separated by a space and hit enter

High Dietary Acid Load Predicts ESRD among Adults with CKD.
J Am Soc Nephrol. 2015 Jul; 26(7):1693-700.JA

Abstract

Small clinical trials have shown that a reduction in dietary acid load (DAL) improves kidney injury and slows kidney function decline; however, the relationship between DAL and risk of ESRD in a population-based cohort with CKD remains unexamined. We examined the association between DAL, quantified by net acid excretion (NAEes), and progression to ESRD in a nationally representative sample of adults in the United States. Among 1486 adults with CKD age≥20 years enrolled in the National Health and Nutrition Examination Survey III, DAL was determined by 24-h dietary recall questionnaire. The development of ESRD was ascertained over a median 14.2 years of follow-up through linkage with the Medicare ESRD Registry. We used the Fine-Gray competing risks method to estimate the association of high, medium, and low DAL with ESRD after adjusting for demographics, nutritional factors, clinical factors, and kidney function/damage markers and accounting for intervening mortality events. In total, 311 (20.9%) participants developed ESRD. Higher levels of DAL were associated with increased risk of ESRD; relative hazards (95% confidence interval) were 3.04 (1.58 to 5.86) for the highest tertile and 1.81 (0.89 to 3.68) for the middle tertile compared with the lowest tertile in the fully adjusted model. The risk of ESRD associated with DAL tertiles increased as eGFR decreased (P trend=0.001). Among participants with albuminuria, high DAL was strongly associated with ESRD risk (P trend=0.03). In conclusion, high DAL in persons with CKD is independently associated with increased risk of ESRD in a nationally representative population.

Links

PMC Free PDF

Authors+Show Affiliations

Banerjee T
Division of General Internal Medicine, Department of Medicine, University of California, San Francisco, California; banerjeet@medsfgh.ucsf.edu.
Crews DC
Division of Nephrology, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland; Welch Center for Prevention, Epidemiology and Clinical Research, Johns Hopkins Medical Institutions, Baltimore, Maryland;
Wesson DE
Department of Internal Medicine, Texas A&M College of Medicine and Scott and White Healthcare, Temple, Texas;
Tilea AM
Kidney Epidemiology and Cost Center and.
Saran R
Kidney Epidemiology and Cost Center and Division of Nephrology, Department of Medicine, University of Michigan, Ann Arbor, Michigan;
Ríos-Burrows N
Division of Diabetes Translation, Centers of Disease and Control and Prevention, Atlanta, Georgia; and.
Williams DE
Division of Diabetes Translation, Centers of Disease and Control and Prevention, Atlanta, Georgia; and.
Powe NR
Division of General Internal Medicine, Department of Medicine, University of California, San Francisco, California; Department of Medicine, San Francisco General Hospital, San Francisco, California.
Centers for Disease Control and Prevention Chronic Kidney Disease Surveillance Team
No affiliation info available

MeSH

AcidosisAcidsAdultAge DistributionAgedCaliforniaComorbidityDatabases, FactualDietary SupplementsDisease ProgressionFemaleGlomerular Filtration RateHumansIncidenceKidney Failure, ChronicKidney Function TestsMaleMiddle AgedNutrition SurveysPrognosisRenal Insufficiency, ChronicRisk AssessmentSeverity of Illness IndexSex Distribution

Pub Type(s)

Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, P.H.S.

Language

eng

PubMed ID

25677388

Citation

Banerjee, Tanushree, et al. "High Dietary Acid Load Predicts ESRD Among Adults With CKD." Journal of the American Society of Nephrology : JASN, vol. 26, no. 7, 2015, pp. 1693-700.
Banerjee T, Crews DC, Wesson DE, et al. High Dietary Acid Load Predicts ESRD among Adults with CKD. J Am Soc Nephrol. 2015;26(7):1693-700.
Banerjee, T., Crews, D. C., Wesson, D. E., Tilea, A. M., Saran, R., Ríos-Burrows, N., Williams, D. E., & Powe, N. R. (2015). High Dietary Acid Load Predicts ESRD among Adults with CKD. Journal of the American Society of Nephrology : JASN, 26(7), 1693-700. https://doi.org/10.1681/ASN.2014040332
Banerjee T, et al. High Dietary Acid Load Predicts ESRD Among Adults With CKD. J Am Soc Nephrol. 2015;26(7):1693-700. PubMed PMID: 25677388.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - High Dietary Acid Load Predicts ESRD among Adults with CKD. AU - Banerjee,Tanushree, AU - Crews,Deidra C, AU - Wesson,Donald E, AU - Tilea,Anca M, AU - Saran,Rajiv, AU - Ríos-Burrows,Nilka, AU - Williams,Desmond E, AU - Powe,Neil R, AU - ,, Y1 - 2015/02/12/ PY - 2014/04/05/received PY - 2014/09/12/accepted PY - 2015/2/14/entrez PY - 2015/2/14/pubmed PY - 2015/9/12/medline KW - ESRD KW - albuminuria KW - nutrition KW - risk factors SP - 1693 EP - 700 JF - Journal of the American Society of Nephrology : JASN JO - J Am Soc Nephrol VL - 26 IS - 7 N2 - Small clinical trials have shown that a reduction in dietary acid load (DAL) improves kidney injury and slows kidney function decline; however, the relationship between DAL and risk of ESRD in a population-based cohort with CKD remains unexamined. We examined the association between DAL, quantified by net acid excretion (NAEes), and progression to ESRD in a nationally representative sample of adults in the United States. Among 1486 adults with CKD age≥20 years enrolled in the National Health and Nutrition Examination Survey III, DAL was determined by 24-h dietary recall questionnaire. The development of ESRD was ascertained over a median 14.2 years of follow-up through linkage with the Medicare ESRD Registry. We used the Fine-Gray competing risks method to estimate the association of high, medium, and low DAL with ESRD after adjusting for demographics, nutritional factors, clinical factors, and kidney function/damage markers and accounting for intervening mortality events. In total, 311 (20.9%) participants developed ESRD. Higher levels of DAL were associated with increased risk of ESRD; relative hazards (95% confidence interval) were 3.04 (1.58 to 5.86) for the highest tertile and 1.81 (0.89 to 3.68) for the middle tertile compared with the lowest tertile in the fully adjusted model. The risk of ESRD associated with DAL tertiles increased as eGFR decreased (P trend=0.001). Among participants with albuminuria, high DAL was strongly associated with ESRD risk (P trend=0.03). In conclusion, high DAL in persons with CKD is independently associated with increased risk of ESRD in a nationally representative population. SN - 1533-3450 UR - https://www.unboundmedicine.com/medline/citation/25677388/full_citation DB - PRIME DP - Unbound Medicine ER -
Grapherence [↓99 ↑25]

Related Citations

    More

    Others Viewed