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Metabolic syndrome: An independent risk factor for erectile dysfunction.
Indian J Endocrinol Metab 2015 Mar-Apr; 19(2):277-82IJ

Abstract

OBJECTIVE

The objective was to determine the role of various components of metabolic syndrome (MetS) as independent risk factor for erectile dysfunction (ED).

MATERIALS AND METHODS

A total of 113 subjects of MetS, as recommended by recent IDF and AHA/NHLBI joint interim statement were selected for study who presented for ED. After doing Anthropometric examination, fasting laboratory assay for fasting plasma glucose (FPG), fasting insulin, hemoglobin A1c, triglyceride (TG), high-density lipoprotein (HDL), low-density lipoprotein (LDL), and 2 h oral glucose tolerance test (OGTT) was done. Erectile function was assessed by completing questions one through five of the International Index of Erectile Function (IIEF-5). A multiple linear regression analysis was carried out on 66 subjects with IIEF-5 score as dependent variable and components of MetS FPG, 2 h OGTT, TG, HDL, and waist circumference as independent variables.

RESULTS

Using a multiple linear regression analysis, we observed that presence of the various components of MetS was associated with ED and a decrease IIEF-5 score and this effect was greater than the effect associated with any of the individual components. Of the individual components of the MetS, HDL (B = 0.136; P = 0.004) and FPG (B = -0.069; P = 0.007) conferred the strongest effect on IIEF-5 score. However, overall age had most significant effect on IIEF-5 score.

CONCLUSION

It is crucial to formulate strategies and implement them to prevent or control the epidemic of the MetS and its consequences. The early identification and treatment of risk factors might be helpful to prevent ED and secondary cardiovascular disease, including diet and lifestyle interventions.

Authors+Show Affiliations

Department of Endocrinology, LLRM Medical College, Meerut, India.Department of Biochemistry, Subharti Medical College, Meerut, India.Department of Endocrinology, LLRM Medical College, Meerut, India.Department of Endocrinology, Pushpagiri Medical College Thiruvalla, Kerala.Department of Endocrinology, Hormone Care and Research Centre, Ghaziabad, Uttar Pradesh, India.Department of Ophthalmology, Subharti Medical College, Meerut, India.Department of Endocrinology, LLRM Medical College, Meerut, India.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

25729692

Citation

Sanjay, Saran, et al. "Metabolic Syndrome: an Independent Risk Factor for Erectile Dysfunction." Indian Journal of Endocrinology and Metabolism, vol. 19, no. 2, 2015, pp. 277-82.
Sanjay S, Bharti GS, Manish G, et al. Metabolic syndrome: An independent risk factor for erectile dysfunction. Indian J Endocrinol Metab. 2015;19(2):277-82.
Sanjay, S., Bharti, G. S., Manish, G., Rajeev, P., Pankaj, A., Puspalata, A., & Keshavkumar, G. (2015). Metabolic syndrome: An independent risk factor for erectile dysfunction. Indian Journal of Endocrinology and Metabolism, 19(2), pp. 277-82. doi:10.4103/2230-8210.149322.
Sanjay S, et al. Metabolic Syndrome: an Independent Risk Factor for Erectile Dysfunction. Indian J Endocrinol Metab. 2015;19(2):277-82. PubMed PMID: 25729692.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Metabolic syndrome: An independent risk factor for erectile dysfunction. AU - Sanjay,Saran, AU - Bharti,Gupta Sona, AU - Manish,Gutch, AU - Rajeev,Philip, AU - Pankaj,Agrawal, AU - Puspalata,Agroiya, AU - Keshavkumar,Gupta, PY - 2015/3/3/entrez PY - 2015/3/3/pubmed PY - 2015/3/3/medline KW - Erectile dysfunction KW - international index of erectile function 5 score KW - metabolic syndrome SP - 277 EP - 82 JF - Indian journal of endocrinology and metabolism JO - Indian J Endocrinol Metab VL - 19 IS - 2 N2 - OBJECTIVE: The objective was to determine the role of various components of metabolic syndrome (MetS) as independent risk factor for erectile dysfunction (ED). MATERIALS AND METHODS: A total of 113 subjects of MetS, as recommended by recent IDF and AHA/NHLBI joint interim statement were selected for study who presented for ED. After doing Anthropometric examination, fasting laboratory assay for fasting plasma glucose (FPG), fasting insulin, hemoglobin A1c, triglyceride (TG), high-density lipoprotein (HDL), low-density lipoprotein (LDL), and 2 h oral glucose tolerance test (OGTT) was done. Erectile function was assessed by completing questions one through five of the International Index of Erectile Function (IIEF-5). A multiple linear regression analysis was carried out on 66 subjects with IIEF-5 score as dependent variable and components of MetS FPG, 2 h OGTT, TG, HDL, and waist circumference as independent variables. RESULTS: Using a multiple linear regression analysis, we observed that presence of the various components of MetS was associated with ED and a decrease IIEF-5 score and this effect was greater than the effect associated with any of the individual components. Of the individual components of the MetS, HDL (B = 0.136; P = 0.004) and FPG (B = -0.069; P = 0.007) conferred the strongest effect on IIEF-5 score. However, overall age had most significant effect on IIEF-5 score. CONCLUSION: It is crucial to formulate strategies and implement them to prevent or control the epidemic of the MetS and its consequences. The early identification and treatment of risk factors might be helpful to prevent ED and secondary cardiovascular disease, including diet and lifestyle interventions. SN - 2230-8210 UR - https://www.unboundmedicine.com/medline/citation/25729692/full_citation L2 - http://www.ijem.in/article.asp?issn=2230-8210;year=2015;volume=19;issue=2;spage=277;epage=282;aulast=Sanjay DB - PRIME DP - Unbound Medicine ER -