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Omega-3 polyunsaturated fatty acids and non-communicable diseases: meta-analysis based systematic review.
Asia Pac J Clin Nutr 2015; 24(1):10-5AP

Abstract

The aim of this updated systematic review is to summarize the evidence of the effect of omega-3 polyunsaturated fatty acids (n-3 PUFA) on non-communicable diseases (NCDs). Publications of meta-analysis up to August 2014 were systematically searched from PubMed, the Cochrane and EMBASE databases. N-3 PUFAs have the following beneficial effects; cardio-protective effects, reduce ischemic stroke risk in both men and women and total stroke risk in women, increase insulin sensitivity in Asians, decrease risk of breast cancer and colorectal cancer in men. However, n-3 PUFAs may have unfavourable effects on type 2 diabetes in Caucasians. In conclusion, n-3 PUFA plays a crucial role in the prevention of NCDs, however, unfavourable effects should be considered in subjects with certain clinical conditions. Cross-cultural studies on the effect of n-3 PUFA on type 2 diabetes are needed to verify why diabetic patients with different ancestries have a different response to n-3 PUFA.

Authors+Show Affiliations

Department of Food Science and Nutrition, Zhejiang University, 866 Yu-hang-tang Road, Hangzhou, 310058, China, . Email: duoli@zju.edu.cn. Department of Nutrition and Dietetics, Monash University, Melbourne, Australia. School of Public Health, Ningxia University, Ningxia, China.

Pub Type(s)

Journal Article
Meta-Analysis
Review
Systematic Review

Language

eng

PubMed ID

25740737

Citation

Li, Duo. "Omega-3 Polyunsaturated Fatty Acids and Non-communicable Diseases: Meta-analysis Based Systematic Review." Asia Pacific Journal of Clinical Nutrition, vol. 24, no. 1, 2015, pp. 10-5.
Li D. Omega-3 polyunsaturated fatty acids and non-communicable diseases: meta-analysis based systematic review. Asia Pac J Clin Nutr. 2015;24(1):10-5.
Li, D. (2015). Omega-3 polyunsaturated fatty acids and non-communicable diseases: meta-analysis based systematic review. Asia Pacific Journal of Clinical Nutrition, 24(1), pp. 10-5. doi:10.6133/apjcn.2015.24.1.21.
Li D. Omega-3 Polyunsaturated Fatty Acids and Non-communicable Diseases: Meta-analysis Based Systematic Review. Asia Pac J Clin Nutr. 2015;24(1):10-5. PubMed PMID: 25740737.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Omega-3 polyunsaturated fatty acids and non-communicable diseases: meta-analysis based systematic review. A1 - Li,Duo, PY - 2015/3/6/entrez PY - 2015/3/6/pubmed PY - 2015/4/25/medline SP - 10 EP - 5 JF - Asia Pacific journal of clinical nutrition JO - Asia Pac J Clin Nutr VL - 24 IS - 1 N2 - The aim of this updated systematic review is to summarize the evidence of the effect of omega-3 polyunsaturated fatty acids (n-3 PUFA) on non-communicable diseases (NCDs). Publications of meta-analysis up to August 2014 were systematically searched from PubMed, the Cochrane and EMBASE databases. N-3 PUFAs have the following beneficial effects; cardio-protective effects, reduce ischemic stroke risk in both men and women and total stroke risk in women, increase insulin sensitivity in Asians, decrease risk of breast cancer and colorectal cancer in men. However, n-3 PUFAs may have unfavourable effects on type 2 diabetes in Caucasians. In conclusion, n-3 PUFA plays a crucial role in the prevention of NCDs, however, unfavourable effects should be considered in subjects with certain clinical conditions. Cross-cultural studies on the effect of n-3 PUFA on type 2 diabetes are needed to verify why diabetic patients with different ancestries have a different response to n-3 PUFA. SN - 0964-7058 UR - https://www.unboundmedicine.com/medline/citation/25740737/full_citation L2 - http://apjcn.nhri.org.tw/server/APJCN/24/1/10.pdf DB - PRIME DP - Unbound Medicine ER -