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Physical activity and risk of pancreatic cancer: a systematic review and meta-analysis.
Eur J Epidemiol 2015; 30(4):279-98EJ

Abstract

Physical activity may prevent pancreatic cancer by regulating body weight and decreasing insulin resistance, DNA damage, and chronic inflammation. Previous meta-analyses found inconsistent evidence for a protective effect of physical activity on pancreatic cancer but those studies did not investigate whether the association between physical activity and pancreatic cancer varies by smoking status, body mass index (BMI), or level of consistency of physical activity over time. To address these issues, we conducted an updated meta-analysis following the PRISMA guidelines among 30 distinct studies with a total of 10,501 pancreatic cancer cases. Random effects meta-analysis of cohort studies revealed a weak, statistically significant reduction in pancreatic cancer risk for high versus low levels of physical activity (relative risk (RR) 0.93, 95 % confidence interval (CI) 0.88-0.98). By comparison, case-control studies yielded a stronger, statistically significant risk reduction (RR 0.78, 95 % CI 0.66-0.94; p-difference by study design = 0.07). When focusing on cohort studies, physical activity summary risk estimates appeared to be more pronounced for consistent physical activity over time (RR 0.86, 95 % CI 0.76-0.97) than for recent past physical activity (RR 0.95, 95 % CI 0.90-1.01) or distant past physical activity (RR 0.95, 95 % CI 0.79-1.15, p-difference by timing in life of physical activity = 0.36). Physical activity summary risk estimates did not differ by smoking status or BMI. In conclusion, physical activity is not strongly associated with pancreatic cancer risk, and the relation is not modified by smoking status or BMI level. While overall findings were weak, we did find some suggestion of potential pancreatic cancer risk reduction with consistent physical activity over time.

Authors+Show Affiliations

Department of Epidemiology and Preventive Medicine, University of Regensburg, Franz-Josef-Strauss-Allee 11, 93053, Regensburg, Germany, gundula.behrens@klinik.uni-regensburg.de.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Meta-Analysis
Review
Systematic Review

Language

eng

PubMed ID

25773752

Citation

Behrens, Gundula, et al. "Physical Activity and Risk of Pancreatic Cancer: a Systematic Review and Meta-analysis." European Journal of Epidemiology, vol. 30, no. 4, 2015, pp. 279-98.
Behrens G, Jochem C, Schmid D, et al. Physical activity and risk of pancreatic cancer: a systematic review and meta-analysis. Eur J Epidemiol. 2015;30(4):279-98.
Behrens, G., Jochem, C., Schmid, D., Keimling, M., Ricci, C., & Leitzmann, M. F. (2015). Physical activity and risk of pancreatic cancer: a systematic review and meta-analysis. European Journal of Epidemiology, 30(4), pp. 279-98. doi:10.1007/s10654-015-0014-9.
Behrens G, et al. Physical Activity and Risk of Pancreatic Cancer: a Systematic Review and Meta-analysis. Eur J Epidemiol. 2015;30(4):279-98. PubMed PMID: 25773752.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Physical activity and risk of pancreatic cancer: a systematic review and meta-analysis. AU - Behrens,Gundula, AU - Jochem,Carmen, AU - Schmid,Daniela, AU - Keimling,Marlen, AU - Ricci,Cristian, AU - Leitzmann,Michael F, Y1 - 2015/03/15/ PY - 2014/08/18/received PY - 2015/03/03/accepted PY - 2015/3/17/entrez PY - 2015/3/17/pubmed PY - 2015/6/9/medline SP - 279 EP - 98 JF - European journal of epidemiology JO - Eur. J. Epidemiol. VL - 30 IS - 4 N2 - Physical activity may prevent pancreatic cancer by regulating body weight and decreasing insulin resistance, DNA damage, and chronic inflammation. Previous meta-analyses found inconsistent evidence for a protective effect of physical activity on pancreatic cancer but those studies did not investigate whether the association between physical activity and pancreatic cancer varies by smoking status, body mass index (BMI), or level of consistency of physical activity over time. To address these issues, we conducted an updated meta-analysis following the PRISMA guidelines among 30 distinct studies with a total of 10,501 pancreatic cancer cases. Random effects meta-analysis of cohort studies revealed a weak, statistically significant reduction in pancreatic cancer risk for high versus low levels of physical activity (relative risk (RR) 0.93, 95 % confidence interval (CI) 0.88-0.98). By comparison, case-control studies yielded a stronger, statistically significant risk reduction (RR 0.78, 95 % CI 0.66-0.94; p-difference by study design = 0.07). When focusing on cohort studies, physical activity summary risk estimates appeared to be more pronounced for consistent physical activity over time (RR 0.86, 95 % CI 0.76-0.97) than for recent past physical activity (RR 0.95, 95 % CI 0.90-1.01) or distant past physical activity (RR 0.95, 95 % CI 0.79-1.15, p-difference by timing in life of physical activity = 0.36). Physical activity summary risk estimates did not differ by smoking status or BMI. In conclusion, physical activity is not strongly associated with pancreatic cancer risk, and the relation is not modified by smoking status or BMI level. While overall findings were weak, we did find some suggestion of potential pancreatic cancer risk reduction with consistent physical activity over time. SN - 1573-7284 UR - https://www.unboundmedicine.com/medline/citation/25773752/full_citation L2 - https://doi.org/10.1007/s10654-015-0014-9 DB - PRIME DP - Unbound Medicine ER -