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Red and processed meat intake and risk of breast cancer: a meta-analysis of prospective studies.

Abstract

Epidemiological studies regarding the association between red and processed meat intake and the risk of breast cancer have yielded inconsistent results. Therefore, we conducted an updated and comprehensive meta-analysis which included 14 prospective studies to evaluate the association of red and processed meat intake with breast cancer risk. Relevant prospective cohort studies were identified by searching PubMed through October 31, 2014, and by reviewing the reference lists of retrieved articles. Study-specific relative risk (RR) estimates were pooled using a random-effects model. Fourteen prospective studies on red meat (involving 31,552 cases) and 12 prospective studies on processed meat were included in the meta-analysis. The summary RRs (95 % CI) of breast cancer for the highest versus the lowest categories were 1.10 (1.02, 1.19) for red meat, and 1.08 (1.01, 1.15) for processed meat. The estimated summary RRs (95 % CI) were 1.11 (1.05, 1.16) for an increase of 120 g/day of red meat, and 1.09 (1.03, 1.16) for an increase of 50 g/day of processed meat. Our findings indicate that increased intake of red and processed meat is associated with an increased risk of breast cancer. Further research with well-designed cohort or interventional studies is needed to confirm the association.

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  • Publisher Full Text
  • Authors+Show Affiliations

    ,

    Key Laboratory of Food Safety Research, Institute for Nutritional Sciences, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, University of Chinese Academy of Sciences, 294 Taiyuan Road, Shanghai, 200031, China.

    ,

    Source

    Breast cancer research and treatment 151:1 2015 May pg 191-8

    MeSH

    Breast Neoplasms
    Female
    Food Handling
    Humans
    Meat
    Risk Factors

    Pub Type(s)

    Journal Article
    Meta-Analysis
    Research Support, Non-U.S. Gov't

    Language

    eng

    PubMed ID

    25893586

    Citation

    Guo, Jingyu, et al. "Red and Processed Meat Intake and Risk of Breast Cancer: a Meta-analysis of Prospective Studies." Breast Cancer Research and Treatment, vol. 151, no. 1, 2015, pp. 191-8.
    Guo J, Wei W, Zhan L. Red and processed meat intake and risk of breast cancer: a meta-analysis of prospective studies. Breast Cancer Res Treat. 2015;151(1):191-8.
    Guo, J., Wei, W., & Zhan, L. (2015). Red and processed meat intake and risk of breast cancer: a meta-analysis of prospective studies. Breast Cancer Research and Treatment, 151(1), pp. 191-8. doi:10.1007/s10549-015-3380-9.
    Guo J, Wei W, Zhan L. Red and Processed Meat Intake and Risk of Breast Cancer: a Meta-analysis of Prospective Studies. Breast Cancer Res Treat. 2015;151(1):191-8. PubMed PMID: 25893586.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Red and processed meat intake and risk of breast cancer: a meta-analysis of prospective studies. AU - Guo,Jingyu, AU - Wei,Wei, AU - Zhan,Lixing, Y1 - 2015/04/19/ PY - 2015/01/30/received PY - 2015/04/09/accepted PY - 2015/4/21/entrez PY - 2015/4/22/pubmed PY - 2016/1/26/medline SP - 191 EP - 8 JF - Breast cancer research and treatment JO - Breast Cancer Res. Treat. VL - 151 IS - 1 N2 - Epidemiological studies regarding the association between red and processed meat intake and the risk of breast cancer have yielded inconsistent results. Therefore, we conducted an updated and comprehensive meta-analysis which included 14 prospective studies to evaluate the association of red and processed meat intake with breast cancer risk. Relevant prospective cohort studies were identified by searching PubMed through October 31, 2014, and by reviewing the reference lists of retrieved articles. Study-specific relative risk (RR) estimates were pooled using a random-effects model. Fourteen prospective studies on red meat (involving 31,552 cases) and 12 prospective studies on processed meat were included in the meta-analysis. The summary RRs (95 % CI) of breast cancer for the highest versus the lowest categories were 1.10 (1.02, 1.19) for red meat, and 1.08 (1.01, 1.15) for processed meat. The estimated summary RRs (95 % CI) were 1.11 (1.05, 1.16) for an increase of 120 g/day of red meat, and 1.09 (1.03, 1.16) for an increase of 50 g/day of processed meat. Our findings indicate that increased intake of red and processed meat is associated with an increased risk of breast cancer. Further research with well-designed cohort or interventional studies is needed to confirm the association. SN - 1573-7217 UR - https://www.unboundmedicine.com/medline/citation/25893586/full_citation L2 - https://doi.org/10.1007/s10549-015-3380-9 DB - PRIME DP - Unbound Medicine ER -