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Migraine and body mass index categories: a systematic review and meta-analysis of observational studies.

Abstract

BACKGROUND

Several studies have assessed the associations between migraine and underweight, pre-obesity or obesity, with conflicting results. To assess the consistency of the data on the topic, we performed a systematic review and meta-analysis of the available observational studies.

METHODS

Multiple electronic databases were systematically searched up to October 2014 for studies assessing the association between migraine and body mass index categories (underweight, pre-obesity, or obesity).

RESULTS

Out of 2,022 records, we included 15 studies. When considering the 11 studies following the World Health Organization BMI cutoffs, we found an increased risk of having migraine in underweight subjects (pooled adjusted effect estimate [PAEE] 1.21; 95% CI, 1.07-1.37; P = 0.002) and in obese women (PAEE 1.44; 95% CI, 1.05-1.97; P = 0.023) as compared with normal weight subjects; additionally, pre-obese subjects had an increased risk of having chronic migraine (PAEE 1.39; 95% CI, 1.13-1.71; P = 0.002). When considering all the 15 studies, we additionally found an increased risk of having migraine in obese as compared with normal weight subjects (PAEE 1.14; 95% CI, 1.02-1.27; P = 0.017); additionally, obese subjects had an increased risk of having chronic migraine (PAEE 1.75; 95% CI, 1.33-2.29; P < 0.001). The pooled analysis did not indicate an increased risk of having migraine in pre-obese subjects.

CONCLUSIONS

The meta-analysis of the available observational studies suggested an association between migraine and obesity likely mediated by gender and migraine frequency. Further studies taking into account gender, migraine type, frequency, activity, and duration could provide more robust evidence.

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  • Authors+Show Affiliations

    ,

    Department of Applied Clinical Sciences and Biotechnology, Institute of Neurology, University of L'Aquila, 67100, L'Aquila, Italy. raffaele.ornello@gmail.com.

    ,

    Department of Applied Clinical Sciences and Biotechnology, Institute of Neurology, University of L'Aquila, 67100, L'Aquila, Italy. ripapatrizia@gmail.com.

    ,

    Department of Applied Clinical Sciences and Biotechnology, Institute of Neurology, University of L'Aquila, 67100, L'Aquila, Italy. pistoiafrancesca@hotmail.com.

    ,

    Department of Applied Clinical Sciences and Biotechnology, Institute of Neurology, University of L'Aquila, 67100, L'Aquila, Italy. degandiana@gmail.com.

    ,

    Department of Applied Clinical Sciences and Biotechnology, Institute of Neurology, University of L'Aquila, 67100, L'Aquila, Italy. cindy.tiseo@gmail.com.

    ,

    Department of Applied Clinical Sciences and Biotechnology, Institute of Neurology, University of L'Aquila, 67100, L'Aquila, Italy. a_carolei@yahoo.com.

    Department of Applied Clinical Sciences and Biotechnology, Institute of Neurology, University of L'Aquila, 67100, L'Aquila, Italy. simona.sacco@yahoo.com.

    Source

    The journal of headache and pain 16: 2015 Mar 28 pg 27

    MeSH

    Body Mass Index
    Comorbidity
    Female
    Humans
    Male
    Migraine Disorders
    Obesity
    Risk
    Thinness

    Pub Type(s)

    Journal Article
    Meta-Analysis
    Review
    Systematic Review

    Language

    eng

    PubMed ID

    25903159

    Citation

    Ornello, Raffaele, et al. "Migraine and Body Mass Index Categories: a Systematic Review and Meta-analysis of Observational Studies." The Journal of Headache and Pain, vol. 16, 2015, p. 27.
    Ornello R, Ripa P, Pistoia F, et al. Migraine and body mass index categories: a systematic review and meta-analysis of observational studies. J Headache Pain. 2015;16:27.
    Ornello, R., Ripa, P., Pistoia, F., Degan, D., Tiseo, C., Carolei, A., & Sacco, S. (2015). Migraine and body mass index categories: a systematic review and meta-analysis of observational studies. The Journal of Headache and Pain, 16, p. 27. doi:10.1186/s10194-015-0510-z.
    Ornello R, et al. Migraine and Body Mass Index Categories: a Systematic Review and Meta-analysis of Observational Studies. J Headache Pain. 2015 Mar 28;16:27. PubMed PMID: 25903159.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Migraine and body mass index categories: a systematic review and meta-analysis of observational studies. AU - Ornello,Raffaele, AU - Ripa,Patrizia, AU - Pistoia,Francesca, AU - Degan,Diana, AU - Tiseo,Cindy, AU - Carolei,Antonio, AU - Sacco,Simona, Y1 - 2015/03/28/ PY - 2015/01/02/received PY - 2015/03/03/accepted PY - 2015/4/24/entrez PY - 2015/4/24/pubmed PY - 2015/11/18/medline SP - 27 EP - 27 JF - The journal of headache and pain JO - J Headache Pain VL - 16 N2 - BACKGROUND: Several studies have assessed the associations between migraine and underweight, pre-obesity or obesity, with conflicting results. To assess the consistency of the data on the topic, we performed a systematic review and meta-analysis of the available observational studies. METHODS: Multiple electronic databases were systematically searched up to October 2014 for studies assessing the association between migraine and body mass index categories (underweight, pre-obesity, or obesity). RESULTS: Out of 2,022 records, we included 15 studies. When considering the 11 studies following the World Health Organization BMI cutoffs, we found an increased risk of having migraine in underweight subjects (pooled adjusted effect estimate [PAEE] 1.21; 95% CI, 1.07-1.37; P = 0.002) and in obese women (PAEE 1.44; 95% CI, 1.05-1.97; P = 0.023) as compared with normal weight subjects; additionally, pre-obese subjects had an increased risk of having chronic migraine (PAEE 1.39; 95% CI, 1.13-1.71; P = 0.002). When considering all the 15 studies, we additionally found an increased risk of having migraine in obese as compared with normal weight subjects (PAEE 1.14; 95% CI, 1.02-1.27; P = 0.017); additionally, obese subjects had an increased risk of having chronic migraine (PAEE 1.75; 95% CI, 1.33-2.29; P < 0.001). The pooled analysis did not indicate an increased risk of having migraine in pre-obese subjects. CONCLUSIONS: The meta-analysis of the available observational studies suggested an association between migraine and obesity likely mediated by gender and migraine frequency. Further studies taking into account gender, migraine type, frequency, activity, and duration could provide more robust evidence. SN - 1129-2377 UR - https://www.unboundmedicine.com/medline/citation/25903159/full_citation L2 - https://thejournalofheadacheandpain.biomedcentral.com/articles/10.1186/s10194-015-0510-z DB - PRIME DP - Unbound Medicine ER -