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Epidemiology of Acute Hepatitis B in the United States From Population-Based Surveillance, 2006-2011.
Clin Infect Dis. 2015 Aug 15; 61(4):584-92.CI

Abstract

BACKGROUND

An estimated 20 000 new hepatitis B virus (HBV) infections occur each year in the United States. We describe the results of enhanced surveillance for acute hepatitis B at 7 federally funded sites over a 6-year period.

METHODS

Health departments in Colorado, Connecticut, Minnesota, Oregon, Tennessee, 34 counties in New York state, and New York City were supported to conduct enhanced, population-based surveillance for acute HBV from 2006 through 2011. Demographic and risk factor data were collected on symptomatic cases using a standardized form. Serum samples from a subset of cases were also obtained for molecular analysis.

RESULTS

In the 6-year period, 2220 acute hepatitis B cases were reported from the 7 sites. For all sites combined, the incidence rate of HBV infection declined by 19%, but in Tennessee incidence increased by 90%, mainly among persons of white race/ethnicity and those aged 40-49 years. Of all reported cases, 66.1% were male, 57.1% were white, 58.4% were aged 30-49 years, and 60.1% were born in the United States. The most common risk factor identified was any drug use, notably in Tennessee; healthcare exposure was also frequently reported. The most common genotype for all reported cases was HBV genotype A (82%).

CONCLUSIONS

Despite an overall decline in HBV infection, attributable to successful vaccination programs, a rise in incident HBV infection related to drug use is an increasing concern in some localities.

Links

Publisher Full Text (DOI)

Authors+Show Affiliations

Iqbal K
Division of Viral Hepatitis, National Center for HIV/AIDS, Viral Hepatitis, STD, and TB Prevention, Centers for Disease Control and Prevention, Atlanta, Georgia.
Klevens RM
Division of Viral Hepatitis, National Center for HIV/AIDS, Viral Hepatitis, STD, and TB Prevention, Centers for Disease Control and Prevention, Atlanta, Georgia.
Kainer MA
Tennessee Department of Health, Nashville.
Baumgartner J
New York Department of Health and Mental Hygiene, Queens.
Gerard K
Connecticut Department of Public Health, Hartford.
Poissant T
Oregon Health Authority, Portland.
Sweet K
Minnesota Department of Health, Minneapolis.
Vonderwahl C
Colorado Department of Public Health and Environment, Denver.
Knickerbocker T
New York State Department of Public Health, Albany.
Khudyakov Y
Division of Viral Hepatitis, National Center for HIV/AIDS, Viral Hepatitis, STD, and TB Prevention, Centers for Disease Control and Prevention, Atlanta, Georgia.
Xia GL
Division of Viral Hepatitis, National Center for HIV/AIDS, Viral Hepatitis, STD, and TB Prevention, Centers for Disease Control and Prevention, Atlanta, Georgia.
Roberts H
Division of Viral Hepatitis, National Center for HIV/AIDS, Viral Hepatitis, STD, and TB Prevention, Centers for Disease Control and Prevention, Atlanta, Georgia.
Teshale E
Division of Viral Hepatitis, National Center for HIV/AIDS, Viral Hepatitis, STD, and TB Prevention, Centers for Disease Control and Prevention, Atlanta, Georgia.

MeSH

AdolescentAdultAgedAged, 80 and overChildDemographyEpidemiological MonitoringEthnicityFemaleGenotypeHepatitis BHepatitis B virusHumansIncidenceMaleMiddle AgedRisk FactorsSurveys and QuestionnairesUnited StatesYoung Adult

Pub Type(s)

Journal Article
Research Support, U.S. Gov't, P.H.S.

Language

eng

PubMed ID

25904365

Citation

Iqbal, Kashif, et al. "Epidemiology of Acute Hepatitis B in the United States From Population-Based Surveillance, 2006-2011." Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America, vol. 61, no. 4, 2015, pp. 584-92.
Iqbal K, Klevens RM, Kainer MA, et al. Epidemiology of Acute Hepatitis B in the United States From Population-Based Surveillance, 2006-2011. Clin Infect Dis. 2015;61(4):584-92.
Iqbal, K., Klevens, R. M., Kainer, M. A., Baumgartner, J., Gerard, K., Poissant, T., Sweet, K., Vonderwahl, C., Knickerbocker, T., Khudyakov, Y., Xia, G. L., Roberts, H., & Teshale, E. (2015). Epidemiology of Acute Hepatitis B in the United States From Population-Based Surveillance, 2006-2011. Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America, 61(4), 584-92. https://doi.org/10.1093/cid/civ332
Iqbal K, et al. Epidemiology of Acute Hepatitis B in the United States From Population-Based Surveillance, 2006-2011. Clin Infect Dis. 2015 Aug 15;61(4):584-92. PubMed PMID: 25904365.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Epidemiology of Acute Hepatitis B in the United States From Population-Based Surveillance, 2006-2011. AU - Iqbal,Kashif, AU - Klevens,R Monina, AU - Kainer,Marion A, AU - Baumgartner,Jennifer, AU - Gerard,Kristin, AU - Poissant,Tasha, AU - Sweet,Kristin, AU - Vonderwahl,Candace, AU - Knickerbocker,Tracey, AU - Khudyakov,Yury, AU - Xia,Guo-Liang, AU - Roberts,Henry, AU - Teshale,Eyasu, Y1 - 2015/04/22/ PY - 2014/10/17/received PY - 2015/04/15/accepted PY - 2015/4/24/entrez PY - 2015/4/24/pubmed PY - 2016/4/22/medline KW - drug use KW - genotype KW - hepatitis B KW - incidence KW - surveillance SP - 584 EP - 92 JF - Clinical infectious diseases : an official publication of the Infectious Diseases Society of America JO - Clin Infect Dis VL - 61 IS - 4 N2 - BACKGROUND: An estimated 20 000 new hepatitis B virus (HBV) infections occur each year in the United States. We describe the results of enhanced surveillance for acute hepatitis B at 7 federally funded sites over a 6-year period. METHODS: Health departments in Colorado, Connecticut, Minnesota, Oregon, Tennessee, 34 counties in New York state, and New York City were supported to conduct enhanced, population-based surveillance for acute HBV from 2006 through 2011. Demographic and risk factor data were collected on symptomatic cases using a standardized form. Serum samples from a subset of cases were also obtained for molecular analysis. RESULTS: In the 6-year period, 2220 acute hepatitis B cases were reported from the 7 sites. For all sites combined, the incidence rate of HBV infection declined by 19%, but in Tennessee incidence increased by 90%, mainly among persons of white race/ethnicity and those aged 40-49 years. Of all reported cases, 66.1% were male, 57.1% were white, 58.4% were aged 30-49 years, and 60.1% were born in the United States. The most common risk factor identified was any drug use, notably in Tennessee; healthcare exposure was also frequently reported. The most common genotype for all reported cases was HBV genotype A (82%). CONCLUSIONS: Despite an overall decline in HBV infection, attributable to successful vaccination programs, a rise in incident HBV infection related to drug use is an increasing concern in some localities. SN - 1537-6591 UR - https://www.unboundmedicine.com/medline/citation/25904365/full_citation DB - PRIME DP - Unbound Medicine ER -
Grapherence [↓13]

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