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Epidemiology of Acute Hepatitis B in the United States From Population-Based Surveillance, 2006-2011.

Abstract

BACKGROUND

An estimated 20 000 new hepatitis B virus (HBV) infections occur each year in the United States. We describe the results of enhanced surveillance for acute hepatitis B at 7 federally funded sites over a 6-year period.

METHODS

Health departments in Colorado, Connecticut, Minnesota, Oregon, Tennessee, 34 counties in New York state, and New York City were supported to conduct enhanced, population-based surveillance for acute HBV from 2006 through 2011. Demographic and risk factor data were collected on symptomatic cases using a standardized form. Serum samples from a subset of cases were also obtained for molecular analysis.

RESULTS

In the 6-year period, 2220 acute hepatitis B cases were reported from the 7 sites. For all sites combined, the incidence rate of HBV infection declined by 19%, but in Tennessee incidence increased by 90%, mainly among persons of white race/ethnicity and those aged 40-49 years. Of all reported cases, 66.1% were male, 57.1% were white, 58.4% were aged 30-49 years, and 60.1% were born in the United States. The most common risk factor identified was any drug use, notably in Tennessee; healthcare exposure was also frequently reported. The most common genotype for all reported cases was HBV genotype A (82%).

CONCLUSIONS

Despite an overall decline in HBV infection, attributable to successful vaccination programs, a rise in incident HBV infection related to drug use is an increasing concern in some localities.

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  • Publisher Full Text
  • Authors+Show Affiliations

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    Division of Viral Hepatitis, National Center for HIV/AIDS, Viral Hepatitis, STD, and TB Prevention, Centers for Disease Control and Prevention, Atlanta, Georgia.

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    Division of Viral Hepatitis, National Center for HIV/AIDS, Viral Hepatitis, STD, and TB Prevention, Centers for Disease Control and Prevention, Atlanta, Georgia.

    ,

    Tennessee Department of Health, Nashville.

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    New York Department of Health and Mental Hygiene, Queens.

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    Connecticut Department of Public Health, Hartford.

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    Oregon Health Authority, Portland.

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    Minnesota Department of Health, Minneapolis.

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    Colorado Department of Public Health and Environment, Denver.

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    New York State Department of Public Health, Albany.

    ,

    Division of Viral Hepatitis, National Center for HIV/AIDS, Viral Hepatitis, STD, and TB Prevention, Centers for Disease Control and Prevention, Atlanta, Georgia.

    ,

    Division of Viral Hepatitis, National Center for HIV/AIDS, Viral Hepatitis, STD, and TB Prevention, Centers for Disease Control and Prevention, Atlanta, Georgia.

    ,

    Division of Viral Hepatitis, National Center for HIV/AIDS, Viral Hepatitis, STD, and TB Prevention, Centers for Disease Control and Prevention, Atlanta, Georgia.

    Division of Viral Hepatitis, National Center for HIV/AIDS, Viral Hepatitis, STD, and TB Prevention, Centers for Disease Control and Prevention, Atlanta, Georgia.

    Source

    MeSH

    Adolescent
    Adult
    Aged
    Aged, 80 and over
    Child
    Demography
    Epidemiological Monitoring
    Ethnic Groups
    Female
    Genotype
    Hepatitis B
    Hepatitis B virus
    Humans
    Incidence
    Male
    Middle Aged
    Risk Factors
    Surveys and Questionnaires
    United States
    Young Adult

    Pub Type(s)

    Journal Article
    Research Support, U.S. Gov't, P.H.S.

    Language

    eng

    PubMed ID

    25904365

    Citation

    Iqbal, Kashif, et al. "Epidemiology of Acute Hepatitis B in the United States From Population-Based Surveillance, 2006-2011." Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America, vol. 61, no. 4, 2015, pp. 584-92.
    Iqbal K, Klevens RM, Kainer MA, et al. Epidemiology of Acute Hepatitis B in the United States From Population-Based Surveillance, 2006-2011. Clin Infect Dis. 2015;61(4):584-92.
    Iqbal, K., Klevens, R. M., Kainer, M. A., Baumgartner, J., Gerard, K., Poissant, T., ... Teshale, E. (2015). Epidemiology of Acute Hepatitis B in the United States From Population-Based Surveillance, 2006-2011. Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America, 61(4), pp. 584-92. doi:10.1093/cid/civ332.
    Iqbal K, et al. Epidemiology of Acute Hepatitis B in the United States From Population-Based Surveillance, 2006-2011. Clin Infect Dis. 2015 Aug 15;61(4):584-92. PubMed PMID: 25904365.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Epidemiology of Acute Hepatitis B in the United States From Population-Based Surveillance, 2006-2011. AU - Iqbal,Kashif, AU - Klevens,R Monina, AU - Kainer,Marion A, AU - Baumgartner,Jennifer, AU - Gerard,Kristin, AU - Poissant,Tasha, AU - Sweet,Kristin, AU - Vonderwahl,Candace, AU - Knickerbocker,Tracey, AU - Khudyakov,Yury, AU - Xia,Guo-Liang, AU - Roberts,Henry, AU - Teshale,Eyasu, Y1 - 2015/04/22/ PY - 2014/10/17/received PY - 2015/04/15/accepted PY - 2015/4/24/entrez PY - 2015/4/24/pubmed PY - 2016/4/22/medline KW - drug use KW - genotype KW - hepatitis B KW - incidence KW - surveillance SP - 584 EP - 92 JF - Clinical infectious diseases : an official publication of the Infectious Diseases Society of America JO - Clin. Infect. Dis. VL - 61 IS - 4 N2 - BACKGROUND: An estimated 20 000 new hepatitis B virus (HBV) infections occur each year in the United States. We describe the results of enhanced surveillance for acute hepatitis B at 7 federally funded sites over a 6-year period. METHODS: Health departments in Colorado, Connecticut, Minnesota, Oregon, Tennessee, 34 counties in New York state, and New York City were supported to conduct enhanced, population-based surveillance for acute HBV from 2006 through 2011. Demographic and risk factor data were collected on symptomatic cases using a standardized form. Serum samples from a subset of cases were also obtained for molecular analysis. RESULTS: In the 6-year period, 2220 acute hepatitis B cases were reported from the 7 sites. For all sites combined, the incidence rate of HBV infection declined by 19%, but in Tennessee incidence increased by 90%, mainly among persons of white race/ethnicity and those aged 40-49 years. Of all reported cases, 66.1% were male, 57.1% were white, 58.4% were aged 30-49 years, and 60.1% were born in the United States. The most common risk factor identified was any drug use, notably in Tennessee; healthcare exposure was also frequently reported. The most common genotype for all reported cases was HBV genotype A (82%). CONCLUSIONS: Despite an overall decline in HBV infection, attributable to successful vaccination programs, a rise in incident HBV infection related to drug use is an increasing concern in some localities. SN - 1537-6591 UR - https://www.unboundmedicine.com/medline/citation/25904365/full_citation L2 - https://academic.oup.com/cid/article-lookup/doi/10.1093/cid/civ332 DB - PRIME DP - Unbound Medicine ER -