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Can nausea and vomiting be treated with ginger extract?

Abstract

Ginger (Zingiber officinale) is a spice traditionally used to treat indigestion, nausea and vomiting. Ginger extracts accelerate gastric emptying and stimulate gastric antral contractions. These effects are mainly due to the presence of gingerols and shogaols and their activity on cholinergic M receptors and serotonergic 5-HT and 5-HT receptors. Various researches on this subject have led to controversial results, due to the chemical instability of ginger extracts and particularly of gingerols, which are readily-oxidizable substances. A systematic review of double-blind, placebo-controlled, randomized studies highlighted the potential efficacy of ginger on the prevention and treatment of nausea and vomiting of various origins, even though additional controlled studies are needed. This review focuses on pregnancy-induced nausea and vomiting and on chemotherapy induced nausea, and hypothesizes a therapeutic role for ginger extracts in case of side effects, as an alternative to traditional prokinetic drugs such as domperidone, levosulpiride or metoclopramide.

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  • Authors+Show Affiliations

    ,

    Department of Gastroenterology, Policlinico di Monza, Monza, Italy. mariangela.rondanelli@unipv.it.

    , , , ,

    Source

    MeSH

    Animals
    Antiemetics
    Antineoplastic Agents
    Catechols
    Fatty Alcohols
    Female
    Gastric Emptying
    Ginger
    Humans
    Nausea
    Plant Extracts
    Pregnancy
    Pregnancy Complications
    Vomiting

    Pub Type(s)

    Journal Article
    Research Support, Non-U.S. Gov't
    Review
    Systematic Review

    Language

    eng

    PubMed ID

    25912592

    Citation

    Giacosa, A, et al. "Can Nausea and Vomiting Be Treated With Ginger Extract?" European Review for Medical and Pharmacological Sciences, vol. 19, no. 7, 2015, pp. 1291-6.
    Giacosa A, Morazzoni P, Bombardelli E, et al. Can nausea and vomiting be treated with ginger extract? Eur Rev Med Pharmacol Sci. 2015;19(7):1291-6.
    Giacosa, A., Morazzoni, P., Bombardelli, E., Riva, A., Bianchi Porro, G., & Rondanelli, M. (2015). Can nausea and vomiting be treated with ginger extract? European Review for Medical and Pharmacological Sciences, 19(7), pp. 1291-6.
    Giacosa A, et al. Can Nausea and Vomiting Be Treated With Ginger Extract. Eur Rev Med Pharmacol Sci. 2015;19(7):1291-6. PubMed PMID: 25912592.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Can nausea and vomiting be treated with ginger extract? AU - Giacosa,A, AU - Morazzoni,P, AU - Bombardelli,E, AU - Riva,A, AU - Bianchi Porro,G, AU - Rondanelli,M, PY - 2015/4/28/entrez PY - 2015/4/29/pubmed PY - 2015/12/15/medline SP - 1291 EP - 6 JF - European review for medical and pharmacological sciences JO - Eur Rev Med Pharmacol Sci VL - 19 IS - 7 N2 - Ginger (Zingiber officinale) is a spice traditionally used to treat indigestion, nausea and vomiting. Ginger extracts accelerate gastric emptying and stimulate gastric antral contractions. These effects are mainly due to the presence of gingerols and shogaols and their activity on cholinergic M receptors and serotonergic 5-HT and 5-HT receptors. Various researches on this subject have led to controversial results, due to the chemical instability of ginger extracts and particularly of gingerols, which are readily-oxidizable substances. A systematic review of double-blind, placebo-controlled, randomized studies highlighted the potential efficacy of ginger on the prevention and treatment of nausea and vomiting of various origins, even though additional controlled studies are needed. This review focuses on pregnancy-induced nausea and vomiting and on chemotherapy induced nausea, and hypothesizes a therapeutic role for ginger extracts in case of side effects, as an alternative to traditional prokinetic drugs such as domperidone, levosulpiride or metoclopramide. SN - 2284-0729 UR - https://www.unboundmedicine.com/medline/citation/25912592/full_citation L2 - http://www.europeanreview.org/article/8750 DB - PRIME DP - Unbound Medicine ER -