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The association between BMI and cervical cancer risk: a meta-analysis.

Abstract

The association between BMI and cervical cancer risk is not clear. This meta-analysis was carried out to estimate the association between overweight and obesity and cervical cancer risk. We searched PubMed, Web of Science, Scopus, ScienceDirect, LILACS, and SciELO for observational studies addressing the association between BMI and cervical cancer until February 2015. Data were independently extracted and analyzed using odds ratios and 95% confidence intervals (CIs), on the basis of random-effects models. We identified a total of 3543 references and included nine studies with 128 233 participants. On the basis of the results of case-control and cohort studies, the association between cervical cancer and overweight was estimated to be 1.03 (95% CI: 0.81, 1.25) and 1.10 (95% CI: 1.03, 1.17), respectively. According to the results of case-control and cohort studies, the association between cervical cancer and obesity was estimated to be 1.40 (95% CI: 1.08, 1.71) and 1.08 (95% CI: 0.60, 1.52), respectively. No evidence of heterogeneity and publication bias was observed. The findings from this meta-analysis indicate that overweight is not associated with an increased risk of cervical cancer, but obesity is weakly associated with an increased risk of cervical cancer. However, more evidence, based on large prospective cohort studies, is required to provide conclusive evidence on whether or not BMI is associated with an increased risk of cervical cancer.

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  • Authors+Show Affiliations

    ,

    aDepartment of Epidemiology & Biostatistics, Modeling of Noncommunicable Diseases Research Center, School of Public Health, Hamadan University of Medical Sciences bDepartment of Midwifery, Toyserkan Branch, Islamic Azad University, Toyserkan, Iran.

    Source

    MeSH

    Body Mass Index
    Female
    Humans
    Obesity
    Prognosis
    Risk Factors
    Uterine Cervical Neoplasms

    Pub Type(s)

    Journal Article
    Meta-Analysis
    Research Support, Non-U.S. Gov't
    Review

    Language

    eng

    PubMed ID

    25932869

    Citation

    Poorolajal, Jalal, and Ensiyeh Jenabi. "The Association Between BMI and Cervical Cancer Risk: a Meta-analysis." European Journal of Cancer Prevention : the Official Journal of the European Cancer Prevention Organisation (ECP), vol. 25, no. 3, 2016, pp. 232-8.
    Poorolajal J, Jenabi E. The association between BMI and cervical cancer risk: a meta-analysis. Eur J Cancer Prev. 2016;25(3):232-8.
    Poorolajal, J., & Jenabi, E. (2016). The association between BMI and cervical cancer risk: a meta-analysis. European Journal of Cancer Prevention : the Official Journal of the European Cancer Prevention Organisation (ECP), 25(3), pp. 232-8. doi:10.1097/CEJ.0000000000000164.
    Poorolajal J, Jenabi E. The Association Between BMI and Cervical Cancer Risk: a Meta-analysis. Eur J Cancer Prev. 2016;25(3):232-8. PubMed PMID: 25932869.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - The association between BMI and cervical cancer risk: a meta-analysis. AU - Poorolajal,Jalal, AU - Jenabi,Ensiyeh, PY - 2015/5/2/entrez PY - 2015/5/2/pubmed PY - 2016/12/15/medline SP - 232 EP - 8 JF - European journal of cancer prevention : the official journal of the European Cancer Prevention Organisation (ECP) JO - Eur. J. Cancer Prev. VL - 25 IS - 3 N2 - The association between BMI and cervical cancer risk is not clear. This meta-analysis was carried out to estimate the association between overweight and obesity and cervical cancer risk. We searched PubMed, Web of Science, Scopus, ScienceDirect, LILACS, and SciELO for observational studies addressing the association between BMI and cervical cancer until February 2015. Data were independently extracted and analyzed using odds ratios and 95% confidence intervals (CIs), on the basis of random-effects models. We identified a total of 3543 references and included nine studies with 128 233 participants. On the basis of the results of case-control and cohort studies, the association between cervical cancer and overweight was estimated to be 1.03 (95% CI: 0.81, 1.25) and 1.10 (95% CI: 1.03, 1.17), respectively. According to the results of case-control and cohort studies, the association between cervical cancer and obesity was estimated to be 1.40 (95% CI: 1.08, 1.71) and 1.08 (95% CI: 0.60, 1.52), respectively. No evidence of heterogeneity and publication bias was observed. The findings from this meta-analysis indicate that overweight is not associated with an increased risk of cervical cancer, but obesity is weakly associated with an increased risk of cervical cancer. However, more evidence, based on large prospective cohort studies, is required to provide conclusive evidence on whether or not BMI is associated with an increased risk of cervical cancer. SN - 1473-5709 UR - https://www.unboundmedicine.com/medline/citation/25932869/full_citation L2 - http://Insights.ovid.com/pubmed?pmid=25932869 DB - PRIME DP - Unbound Medicine ER -