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Weight loss and impact on quality of life in Parkinson's disease.

Abstract

INTRODUCTION

Weight loss is common in Parkinson's Disease (PD) and sometimes may precede the diagnosis. Weight loss is associated with multiple factors but its impact on health-related quality of life (HRQL) in PD remains unknown. We sought to investigate the factors associated with weight change and to quantify its effect on HRQL.

METHODS

The National Parkinson Foundation Quality Improvement Initiative (NPF-QII) data was used to analyze PD patients longitudinally between two visits, separated by 12 ± 6 months. Multiple linear regression analyses were used to assess the associations between baseline covariates and body weight change per month, and to evaluate whether, and to what degree, Parkinson's Disease Questionnaire (PDQ-39) scores were affected.

RESULTS

A higher Hoehn & Yahr stage, higher number of comorbidities, older age, lower MOCA estimate, and higher rate of levodopa usage were observed in patients who lost weight. Multivariate regression analysis indicated that age and levodopa usage were significantly associated with weight loss. Furthermore, monthly body weight loss was significantly associated with HRQL decline in PD patients. Loss of 1 lb (0.45 kg) per month was associated with a decline in QOL: an increase of 0.5% in PDQ-39 Summary Index score (p=0.004), and 1.1% and 1.5% increases in the mobility and ADL dimensions, respectively.

CONCLUSION

Weight loss in PD is common and seems to correlate with worsened HRQL. Awareness of factors associated with weight loss and its relation to HRQL may help practitioners improve patient management and expectations.

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  • Authors+Show Affiliations

    ,

    Department of Neurology, Brown University, Providence, Rhode Island, United States of America.

    ,

    Department of Mathematics, Clarkson University, Potsdam, New York, United States of America.

    ,

    Department of Biostatistics, University of Florida, Gainesville, Florida, United States of America.

    ,

    Department of Neurology, University of Florida, Gainesville, Florida, United States of America.

    ,

    Department of Neurology, University of Florida, Gainesville, Florida, United States of America.

    ,

    Department of Neurology, University of Florida, Gainesville, Florida, United States of America.

    ,

    Department of Neurology, University of Florida, Gainesville, Florida, United States of America.

    ,

    National Parkinson Foundation, Miami, Florida, United States of America.

    ,

    Department of Biostatistics, University of Florida, Gainesville, Florida, United States of America.

    Department of Neurology, University of Florida, Gainesville, Florida, United States of America.

    Source

    PloS one 10:5 2015 pg e0124541

    MeSH

    Aged
    Demography
    Female
    Humans
    Male
    Parkinson Disease
    Quality of Life
    Regression Analysis
    Surveys and Questionnaires
    Weight Loss

    Pub Type(s)

    Journal Article

    Language

    eng

    PubMed ID

    25938478

    Citation

    TY - JOUR T1 - Weight loss and impact on quality of life in Parkinson's disease. AU - Akbar,Umer, AU - He,Ying, AU - Dai,Yunfeng, AU - Hack,Nawaz, AU - Malaty,Irene, AU - McFarland,Nikolaus R, AU - Hess,Christopher, AU - Schmidt,Peter, AU - Wu,Samuel, AU - Okun,Michael S, Y1 - 2015/05/04/ PY - 2015///ecollection PY - 2014/7/11/received PY - 2015/3/15/accepted PY - 2015/5/4/epublish PY - 2015/5/5/entrez PY - 2015/5/6/pubmed PY - 2016/4/5/medline SP - e0124541 EP - e0124541 JF - PloS one JO - PLoS ONE VL - 10 IS - 5 N2 - INTRODUCTION: Weight loss is common in Parkinson's Disease (PD) and sometimes may precede the diagnosis. Weight loss is associated with multiple factors but its impact on health-related quality of life (HRQL) in PD remains unknown. We sought to investigate the factors associated with weight change and to quantify its effect on HRQL. METHODS: The National Parkinson Foundation Quality Improvement Initiative (NPF-QII) data was used to analyze PD patients longitudinally between two visits, separated by 12 ± 6 months. Multiple linear regression analyses were used to assess the associations between baseline covariates and body weight change per month, and to evaluate whether, and to what degree, Parkinson's Disease Questionnaire (PDQ-39) scores were affected. RESULTS: A higher Hoehn & Yahr stage, higher number of comorbidities, older age, lower MOCA estimate, and higher rate of levodopa usage were observed in patients who lost weight. Multivariate regression analysis indicated that age and levodopa usage were significantly associated with weight loss. Furthermore, monthly body weight loss was significantly associated with HRQL decline in PD patients. Loss of 1 lb (0.45 kg) per month was associated with a decline in QOL: an increase of 0.5% in PDQ-39 Summary Index score (p=0.004), and 1.1% and 1.5% increases in the mobility and ADL dimensions, respectively. CONCLUSION: Weight loss in PD is common and seems to correlate with worsened HRQL. Awareness of factors associated with weight loss and its relation to HRQL may help practitioners improve patient management and expectations. SN - 1932-6203 UR - https://www.unboundmedicine.com/medline/citation/25938478/full_citation L2 - http://dx.plos.org/10.1371/journal.pone.0124541 ER -