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Weight loss and impact on quality of life in Parkinson's disease.
PLoS One. 2015; 10(5):e0124541.Plos

Abstract

INTRODUCTION

Weight loss is common in Parkinson's Disease (PD) and sometimes may precede the diagnosis. Weight loss is associated with multiple factors but its impact on health-related quality of life (HRQL) in PD remains unknown. We sought to investigate the factors associated with weight change and to quantify its effect on HRQL.

METHODS

The National Parkinson Foundation Quality Improvement Initiative (NPF-QII) data was used to analyze PD patients longitudinally between two visits, separated by 12 ± 6 months. Multiple linear regression analyses were used to assess the associations between baseline covariates and body weight change per month, and to evaluate whether, and to what degree, Parkinson's Disease Questionnaire (PDQ-39) scores were affected.

RESULTS

A higher Hoehn & Yahr stage, higher number of comorbidities, older age, lower MOCA estimate, and higher rate of levodopa usage were observed in patients who lost weight. Multivariate regression analysis indicated that age and levodopa usage were significantly associated with weight loss. Furthermore, monthly body weight loss was significantly associated with HRQL decline in PD patients. Loss of 1 lb (0.45 kg) per month was associated with a decline in QOL: an increase of 0.5% in PDQ-39 Summary Index score (p=0.004), and 1.1% and 1.5% increases in the mobility and ADL dimensions, respectively.

CONCLUSION

Weight loss in PD is common and seems to correlate with worsened HRQL. Awareness of factors associated with weight loss and its relation to HRQL may help practitioners improve patient management and expectations.

Links

Authors+Show Affiliations

Department of Neurology, Brown University, Providence, Rhode Island, United States of America.

Department of Mathematics, Clarkson University, Potsdam, New York, United States of America.

Department of Biostatistics, University of Florida, Gainesville, Florida, United States of America.

Department of Neurology, University of Florida, Gainesville, Florida, United States of America.

Department of Neurology, University of Florida, Gainesville, Florida, United States of America.

Department of Neurology, University of Florida, Gainesville, Florida, United States of America.

Department of Neurology, University of Florida, Gainesville, Florida, United States of America.

National Parkinson Foundation, Miami, Florida, United States of America.

Department of Biostatistics, University of Florida, Gainesville, Florida, United States of America.

Department of Neurology, University of Florida, Gainesville, Florida, United States of America.

MeSH

AgedDemographyFemaleHumansMaleParkinson DiseaseQuality of LifeRegression AnalysisSurveys and QuestionnairesWeight Loss

Pub Type(s)

Journal Article

Language

eng

PubMed ID

25938478

Citation

Akbar, Umer, et al. "Weight Loss and Impact On Quality of Life in Parkinson's Disease." PloS One, vol. 10, no. 5, 2015, pp. e0124541.

Akbar U, He Y, Dai Y, et al. Weight loss and impact on quality of life in Parkinson's disease. PLoS One. 2015;10(5):e0124541.

Akbar, U., He, Y., Dai, Y., Hack, N., Malaty, I., McFarland, N. R., Hess, C., Schmidt, P., Wu, S., & Okun, M. S. (2015). Weight loss and impact on quality of life in Parkinson's disease. PloS One, 10(5), e0124541. https://doi.org/10.1371/journal.pone.0124541

Akbar U, et al. Weight Loss and Impact On Quality of Life in Parkinson's Disease. PLoS One. 2015;10(5):e0124541. PubMed PMID: 25938478.

* Article titles in AMA citation format should be in sentence-case

TY - JOUR T1 - Weight loss and impact on quality of life in Parkinson's disease. AU - Akbar,Umer, AU - He,Ying, AU - Dai,Yunfeng, AU - Hack,Nawaz, AU - Malaty,Irene, AU - McFarland,Nikolaus R, AU - Hess,Christopher, AU - Schmidt,Peter, AU - Wu,Samuel, AU - Okun,Michael S, Y1 - 2015/05/04/ PY - 2014/07/11/received PY - 2015/03/15/accepted PY - 2015/5/5/entrez PY - 2015/5/6/pubmed PY - 2016/4/5/medline SP - e0124541 EP - e0124541 JF - PloS one JO - PLoS One VL - 10 IS - 5 N2 - INTRODUCTION: Weight loss is common in Parkinson's Disease (PD) and sometimes may precede the diagnosis. Weight loss is associated with multiple factors but its impact on health-related quality of life (HRQL) in PD remains unknown. We sought to investigate the factors associated with weight change and to quantify its effect on HRQL. METHODS: The National Parkinson Foundation Quality Improvement Initiative (NPF-QII) data was used to analyze PD patients longitudinally between two visits, separated by 12 ± 6 months. Multiple linear regression analyses were used to assess the associations between baseline covariates and body weight change per month, and to evaluate whether, and to what degree, Parkinson's Disease Questionnaire (PDQ-39) scores were affected. RESULTS: A higher Hoehn & Yahr stage, higher number of comorbidities, older age, lower MOCA estimate, and higher rate of levodopa usage were observed in patients who lost weight. Multivariate regression analysis indicated that age and levodopa usage were significantly associated with weight loss. Furthermore, monthly body weight loss was significantly associated with HRQL decline in PD patients. Loss of 1 lb (0.45 kg) per month was associated with a decline in QOL: an increase of 0.5% in PDQ-39 Summary Index score (p=0.004), and 1.1% and 1.5% increases in the mobility and ADL dimensions, respectively. CONCLUSION: Weight loss in PD is common and seems to correlate with worsened HRQL. Awareness of factors associated with weight loss and its relation to HRQL may help practitioners improve patient management and expectations. SN - 1932-6203 UR - https://www.unboundmedicine.com/medline/citation/25938478/full_citation DB - PRIME DP - Unbound Medicine ER -