Type your tag names separated by a space and hit enter

A model for the role of gut bacteria in the development of autoimmunity for type 1 diabetes.

Abstract

Several lines of evidence suggest a role for the gut microbiome in type 1 diabetes. Treating diabetes-prone rodents with probiotics or antibiotics prevents the development of the disorder. Diabetes-prone rodents also have a distinctly different gut microbiome compared with healthy rodents. Recent studies in children with a high genetic risk for type 1 diabetes demonstrate significant differences in the gut microbiome between children who develop autoimmunity for the disease and those who remain healthy. However, the differences in microbiome composition between autoimmune and healthy children are not consistent across all studies because of the strong environmental influences on microbiome composition, particularly diet and geography. Controlling confounding factors of microbiome composition uncovers bacterial associations with disease. For example, in a human cohort from a single Finnish city where geography is confined, a strong association between one dominant bacterial species, Bacteroides dorei, and type 1 diabetes was discovered (Davis-Richardson et al. Front Microbiol 2014;5:678). Beyond this, recent DNA methylation analyses suggest that a thorough epigenetic analysis of the gut microbiome may be warranted. These studies suggest a testable model whereby a diet high in fat and gluten and low in resistant starch may be the primary driver of gut dysbiosis. This dysbiosis may cause a lack of butyrate production by gut bacteria, which, in turn, leads to the development of a permeable gut followed by autoimmunity. The bacterial community responsible for these changes in butyrate production may vary around the world, but bacteria of the genus Bacteroides are thought to play a key role.

Links

  • PMC Free PDF
  • PMC Free Full Text
  • Publisher Full Text
  • Authors+Show Affiliations

    ,

    Microbiology and Cell Science Department, Institute of Food and Agricultural Sciences, 1355 Museum Road, PO Box 110700, Gainesville, FL, 32611-0700, USA.

    Source

    Diabetologia 58:7 2015 Jul pg 1386-93

    MeSH

    Animals
    Butyrates
    Diabetes Mellitus, Type 1
    Diet
    Gastrointestinal Tract
    Humans
    Microbiota

    Pub Type(s)

    Journal Article
    Research Support, Non-U.S. Gov't
    Review

    Language

    eng

    PubMed ID

    25957231

    Citation

    Davis-Richardson, Austin G., and Eric W. Triplett. "A Model for the Role of Gut Bacteria in the Development of Autoimmunity for Type 1 Diabetes." Diabetologia, vol. 58, no. 7, 2015, pp. 1386-93.
    Davis-Richardson AG, Triplett EW. A model for the role of gut bacteria in the development of autoimmunity for type 1 diabetes. Diabetologia. 2015;58(7):1386-93.
    Davis-Richardson, A. G., & Triplett, E. W. (2015). A model for the role of gut bacteria in the development of autoimmunity for type 1 diabetes. Diabetologia, 58(7), pp. 1386-93. doi:10.1007/s00125-015-3614-8.
    Davis-Richardson AG, Triplett EW. A Model for the Role of Gut Bacteria in the Development of Autoimmunity for Type 1 Diabetes. Diabetologia. 2015;58(7):1386-93. PubMed PMID: 25957231.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - A model for the role of gut bacteria in the development of autoimmunity for type 1 diabetes. AU - Davis-Richardson,Austin G, AU - Triplett,Eric W, Y1 - 2015/05/10/ PY - 2014/12/05/received PY - 2015/03/27/accepted PY - 2015/5/10/entrez PY - 2015/5/10/pubmed PY - 2016/3/11/medline SP - 1386 EP - 93 JF - Diabetologia JO - Diabetologia VL - 58 IS - 7 N2 - Several lines of evidence suggest a role for the gut microbiome in type 1 diabetes. Treating diabetes-prone rodents with probiotics or antibiotics prevents the development of the disorder. Diabetes-prone rodents also have a distinctly different gut microbiome compared with healthy rodents. Recent studies in children with a high genetic risk for type 1 diabetes demonstrate significant differences in the gut microbiome between children who develop autoimmunity for the disease and those who remain healthy. However, the differences in microbiome composition between autoimmune and healthy children are not consistent across all studies because of the strong environmental influences on microbiome composition, particularly diet and geography. Controlling confounding factors of microbiome composition uncovers bacterial associations with disease. For example, in a human cohort from a single Finnish city where geography is confined, a strong association between one dominant bacterial species, Bacteroides dorei, and type 1 diabetes was discovered (Davis-Richardson et al. Front Microbiol 2014;5:678). Beyond this, recent DNA methylation analyses suggest that a thorough epigenetic analysis of the gut microbiome may be warranted. These studies suggest a testable model whereby a diet high in fat and gluten and low in resistant starch may be the primary driver of gut dysbiosis. This dysbiosis may cause a lack of butyrate production by gut bacteria, which, in turn, leads to the development of a permeable gut followed by autoimmunity. The bacterial community responsible for these changes in butyrate production may vary around the world, but bacteria of the genus Bacteroides are thought to play a key role. SN - 1432-0428 UR - https://www.unboundmedicine.com/medline/citation/25957231/full_citation L2 - https://dx.doi.org/10.1007/s00125-015-3614-8 DB - PRIME DP - Unbound Medicine ER -