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New developments providing mechanistic insight into the impact of the microbiota on allergic disease.

Abstract

The increase in allergic diseases over the past several decades is correlated with changes in the composition and diversity of the intestinal microbiota. Microbial-derived signals are critical for instructing the developing immune system and conversely, immune regulation can impact the microbiota. Perturbations in the microbiota composition may be especially important during early-life when the immune system is still developing, resulting in a critical window of opportunity for instructing the immune system. This review highlights recent studies investigating the role of the microbiome in susceptibility or development of allergic diseases with a focus on animal models that provide insight into the mechanisms and pathways involved. Identification of a causal link between reduced microbial diversity or altered microbial composition and increased susceptibility to immune-mediated diseases will hopefully pave the way for better preventive therapies.

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  • Authors+Show Affiliations

    ,

    Mucosal Immunology Lab, Department of Clinical Research, University of Bern, Murtenstrasse 35, 3010 Bern, Switzerland. Electronic address: mccoy@dkf.unibe.ch.

    Mucosal Immunology Lab, Department of Clinical Research, University of Bern, Murtenstrasse 35, 3010 Bern, Switzerland.

    Source

    Clinical immunology (Orlando, Fla.) 159:2 2015 Aug pg 170-6

    MeSH

    Animals
    Asthma
    Biodiversity
    Delivery, Obstetric
    Diet
    Disease Susceptibility
    Food Hypersensitivity
    Gastrointestinal Microbiome
    Germ-Free Life
    Humans
    Hygiene Hypothesis
    Hypersensitivity
    Immunoglobulin E
    Intestines
    Lung
    Mice

    Pub Type(s)

    Journal Article
    Research Support, Non-U.S. Gov't
    Review

    Language

    eng

    PubMed ID

    25988860

    Citation

    McCoy, Kathy D., and Yasmin Köller. "New Developments Providing Mechanistic Insight Into the Impact of the Microbiota On Allergic Disease." Clinical Immunology (Orlando, Fla.), vol. 159, no. 2, 2015, pp. 170-6.
    McCoy KD, Köller Y. New developments providing mechanistic insight into the impact of the microbiota on allergic disease. Clin Immunol. 2015;159(2):170-6.
    McCoy, K. D., & Köller, Y. (2015). New developments providing mechanistic insight into the impact of the microbiota on allergic disease. Clinical Immunology (Orlando, Fla.), 159(2), pp. 170-6. doi:10.1016/j.clim.2015.05.007.
    McCoy KD, Köller Y. New Developments Providing Mechanistic Insight Into the Impact of the Microbiota On Allergic Disease. Clin Immunol. 2015;159(2):170-6. PubMed PMID: 25988860.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - New developments providing mechanistic insight into the impact of the microbiota on allergic disease. AU - McCoy,Kathy D, AU - Köller,Yasmin, Y1 - 2015/05/16/ PY - 2014/12/15/received PY - 2015/05/06/revised PY - 2015/05/10/accepted PY - 2015/5/20/entrez PY - 2015/5/20/pubmed PY - 2015/12/15/medline KW - Allergy KW - Germ-free KW - IgE KW - Immune regulation KW - Microbiota SP - 170 EP - 6 JF - Clinical immunology (Orlando, Fla.) JO - Clin. Immunol. VL - 159 IS - 2 N2 - The increase in allergic diseases over the past several decades is correlated with changes in the composition and diversity of the intestinal microbiota. Microbial-derived signals are critical for instructing the developing immune system and conversely, immune regulation can impact the microbiota. Perturbations in the microbiota composition may be especially important during early-life when the immune system is still developing, resulting in a critical window of opportunity for instructing the immune system. This review highlights recent studies investigating the role of the microbiome in susceptibility or development of allergic diseases with a focus on animal models that provide insight into the mechanisms and pathways involved. Identification of a causal link between reduced microbial diversity or altered microbial composition and increased susceptibility to immune-mediated diseases will hopefully pave the way for better preventive therapies. SN - 1521-7035 UR - https://www.unboundmedicine.com/medline/citation/25988860/full_citation L2 - https://linkinghub.elsevier.com/retrieve/pii/S1521-6616(15)00169-2 DB - PRIME DP - Unbound Medicine ER -