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Bone Mineral Density and Protein-Derived Food Clusters from the Framingham Offspring Study.

Abstract

BACKGROUND

Dietary protein is beneficial to bone health; however, dietary patterns of protein intake and their relationship with bone mineral density (BMD) have not been evaluated.

OBJECTIVE

To examine the relationship of dietary protein food clusters with BMD at the femoral neck, trochanter, total femur, and lumbar spine among middle-aged and older men and women.

DESIGN

Cross-sectional study.

PARTICIPANTS AND SETTING

Two thousand seven hundred fifty-eight community-dwelling individuals from the Framingham Offspring Study.

METHODS

BMD was measured by Lunar DPX-L (Lunar Radiation Corporation) in 1996-2001. Dietary intakes were estimated using the Willett food frequency questionnaire in either 1995-1998 or 1998-2001, and the exam closest to a participant's BMD measurement was used. Cluster analysis (FASTCLUS procedure, k-means method) was used to classify participants into groups, determined by major sources of protein. Generalized linear regression was used to compare adjusted least-squares mean BMD across protein food clusters for all pairwise comparisons.

RESULTS

From 2,758 participants (44% men; mean age 61±9 years, range=29 to 86 years), five protein food clusters were identified (chicken, fish, processed foods, red meat, and low-fat milk). Three of these food clusters showed associations with BMD. The red meat protein food cluster presented with significantly lower femoral neck BMD compared with the low-fat milk cluster (red meat 0.898±0.005 g/cm(2) vs low-fat milk 0.919±0.007 g/cm(2); P=0.04). Further, the processed foods protein cluster presented with significantly lower femoral neck BMD compared with the low-fat milk cluster (processed foods 0.897±0.004 g/cm(2) vs low-fat milk 0.919±0.007 g/cm(2); P=0.02). A similar, yet nonsignificant, trend was observed for other BMD sites examined.

CONCLUSIONS

Diets with the greatest proportion of protein intake from red meat and processed foods may not be as beneficial to the skeleton compared with dietary patterns where the highest proportion of protein is derived from low-fat milk.

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    MeSH

    Adult
    Aged
    Aged, 80 and over
    Animals
    Body Mass Index
    Bone Density
    Calcium, Dietary
    Chickens
    Cross-Sectional Studies
    Diet
    Diet Surveys
    Dietary Proteins
    Dietary Supplements
    Energy Intake
    Female
    Femur Neck
    Fishes
    Humans
    Male
    Massachusetts
    Meat
    Middle Aged
    Milk
    Motor Activity
    Nutrition Assessment
    Red Meat
    Seafood
    Surveys and Questionnaires
    Vitamin D

    Pub Type(s)

    Journal Article
    Observational Study
    Research Support, N.I.H., Extramural

    Language

    eng

    PubMed ID

    26038297

    Citation

    Mangano, Kelsey M., et al. "Bone Mineral Density and Protein-Derived Food Clusters From the Framingham Offspring Study." Journal of the Academy of Nutrition and Dietetics, vol. 115, no. 10, 2015, pp. 1605-1613.e1.
    Mangano KM, Sahni S, Kiel DP, et al. Bone Mineral Density and Protein-Derived Food Clusters from the Framingham Offspring Study. J Acad Nutr Diet. 2015;115(10):1605-1613.e1.
    Mangano, K. M., Sahni, S., Kiel, D. P., Tucker, K. L., Dufour, A. B., & Hannan, M. T. (2015). Bone Mineral Density and Protein-Derived Food Clusters from the Framingham Offspring Study. Journal of the Academy of Nutrition and Dietetics, 115(10), pp. 1605-1613.e1. doi:10.1016/j.jand.2015.04.001.
    Mangano KM, et al. Bone Mineral Density and Protein-Derived Food Clusters From the Framingham Offspring Study. J Acad Nutr Diet. 2015;115(10):1605-1613.e1. PubMed PMID: 26038297.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Bone Mineral Density and Protein-Derived Food Clusters from the Framingham Offspring Study. AU - Mangano,Kelsey M, AU - Sahni,Shivani, AU - Kiel,Douglas P, AU - Tucker,Katherine L, AU - Dufour,Alyssa B, AU - Hannan,Marian T, Y1 - 2015/05/30/ PY - 2014/09/08/received PY - 2015/04/01/accepted PY - 2015/6/4/entrez PY - 2015/6/4/pubmed PY - 2016/1/9/medline KW - Aging KW - Bone mineral density KW - Cohort KW - Dietary patterns KW - Dietary protein SP - 1605 EP - 1613.e1 JF - Journal of the Academy of Nutrition and Dietetics JO - J Acad Nutr Diet VL - 115 IS - 10 N2 - BACKGROUND: Dietary protein is beneficial to bone health; however, dietary patterns of protein intake and their relationship with bone mineral density (BMD) have not been evaluated. OBJECTIVE: To examine the relationship of dietary protein food clusters with BMD at the femoral neck, trochanter, total femur, and lumbar spine among middle-aged and older men and women. DESIGN: Cross-sectional study. PARTICIPANTS AND SETTING: Two thousand seven hundred fifty-eight community-dwelling individuals from the Framingham Offspring Study. METHODS: BMD was measured by Lunar DPX-L (Lunar Radiation Corporation) in 1996-2001. Dietary intakes were estimated using the Willett food frequency questionnaire in either 1995-1998 or 1998-2001, and the exam closest to a participant's BMD measurement was used. Cluster analysis (FASTCLUS procedure, k-means method) was used to classify participants into groups, determined by major sources of protein. Generalized linear regression was used to compare adjusted least-squares mean BMD across protein food clusters for all pairwise comparisons. RESULTS: From 2,758 participants (44% men; mean age 61±9 years, range=29 to 86 years), five protein food clusters were identified (chicken, fish, processed foods, red meat, and low-fat milk). Three of these food clusters showed associations with BMD. The red meat protein food cluster presented with significantly lower femoral neck BMD compared with the low-fat milk cluster (red meat 0.898±0.005 g/cm(2) vs low-fat milk 0.919±0.007 g/cm(2); P=0.04). Further, the processed foods protein cluster presented with significantly lower femoral neck BMD compared with the low-fat milk cluster (processed foods 0.897±0.004 g/cm(2) vs low-fat milk 0.919±0.007 g/cm(2); P=0.02). A similar, yet nonsignificant, trend was observed for other BMD sites examined. CONCLUSIONS: Diets with the greatest proportion of protein intake from red meat and processed foods may not be as beneficial to the skeleton compared with dietary patterns where the highest proportion of protein is derived from low-fat milk. SN - 2212-2672 UR - https://www.unboundmedicine.com/medline/citation/26038297/full_citation L2 - https://linkinghub.elsevier.com/retrieve/pii/S2212-2672(15)00392-5 DB - PRIME DP - Unbound Medicine ER -