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Nonmedicinal interventions in nonalcoholic fatty liver disease.
Can J Gastroenterol Hepatol 2015 Jun-Jul; 29(5):241-52CJ

Abstract

Unhealthy diet and lack of physical exercise are responsible for fat accumulation in the liver, which may lead to liver disease. Histologically, the severity of the disease has two stages: nonalcoholic fatty liver disease (NAFLD) and nonalcoholic steatohepatitis (NASH). NAFLD is defined by the presence of steatosis with no evidence of cellular injury such as hepatocyte ballooning. NASH is a distinct entity from NAFLD, and is characterized by the presence of inflammation with hepatocytes damage, with or without fibrosis. While several therapeutic strategies have been proposed to improve this condition, the present review aims to discuss nonmedicinal interventions used to reduce liver involvement or to prevent the disease altogether. The authors investigated dietary patterns and vitamin deficiencies associated with NAFLD, and their role in enhancing disease severity. Additionally, they reviewed the role of exercise and the use of interventions, such as as intragastric balloon and bariatric surgery, for improving disease progression. The authors propose monitoring disease progression or repair by following changes in cytoadipokine levels.

Authors

No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

26076224

Citation

Neuman, Manuela G., et al. "Nonmedicinal Interventions in Nonalcoholic Fatty Liver Disease." Canadian Journal of Gastroenterology & Hepatology, vol. 29, no. 5, 2015, pp. 241-52.
Neuman MG, Nanau RM, Cohen LB. Nonmedicinal interventions in nonalcoholic fatty liver disease. Can J Gastroenterol Hepatol. 2015;29(5):241-52.
Neuman, M. G., Nanau, R. M., & Cohen, L. B. (2015). Nonmedicinal interventions in nonalcoholic fatty liver disease. Canadian Journal of Gastroenterology & Hepatology, 29(5), pp. 241-52.
Neuman MG, Nanau RM, Cohen LB. Nonmedicinal Interventions in Nonalcoholic Fatty Liver Disease. Can J Gastroenterol Hepatol. 2015;29(5):241-52. PubMed PMID: 26076224.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Nonmedicinal interventions in nonalcoholic fatty liver disease. AU - Neuman,Manuela G, AU - Nanau,Radu M, AU - Cohen,Lawrence B, PY - 2015/6/16/entrez PY - 2015/6/16/pubmed PY - 2016/3/10/medline SP - 241 EP - 52 JF - Canadian journal of gastroenterology & hepatology JO - Can J Gastroenterol Hepatol VL - 29 IS - 5 N2 - Unhealthy diet and lack of physical exercise are responsible for fat accumulation in the liver, which may lead to liver disease. Histologically, the severity of the disease has two stages: nonalcoholic fatty liver disease (NAFLD) and nonalcoholic steatohepatitis (NASH). NAFLD is defined by the presence of steatosis with no evidence of cellular injury such as hepatocyte ballooning. NASH is a distinct entity from NAFLD, and is characterized by the presence of inflammation with hepatocytes damage, with or without fibrosis. While several therapeutic strategies have been proposed to improve this condition, the present review aims to discuss nonmedicinal interventions used to reduce liver involvement or to prevent the disease altogether. The authors investigated dietary patterns and vitamin deficiencies associated with NAFLD, and their role in enhancing disease severity. Additionally, they reviewed the role of exercise and the use of interventions, such as as intragastric balloon and bariatric surgery, for improving disease progression. The authors propose monitoring disease progression or repair by following changes in cytoadipokine levels. SN - 2291-2797 UR - https://www.unboundmedicine.com/medline/citation/26076224/full_citation L2 - https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/26076224/ DB - PRIME DP - Unbound Medicine ER -