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High-dose vitamin D3 reduces deficiency caused by low UVB exposure and limits HIV-1 replication in urban Southern Africans.
Proc Natl Acad Sci U S A 2015; 112(26):8052-7PN

Abstract

Cape Town, South Africa, has a seasonal pattern of UVB radiation and a predominantly dark-skinned urban population who suffer high HIV-1 prevalence. This coexistent environmental and phenotypic scenario puts residents at risk for vitamin D deficiency, which may potentiate HIV-1 disease progression. We conducted a longitudinal study in two ethnically distinct groups of healthy young adults in Cape Town, supplemented with vitamin D3 in winter, to determine whether vitamin D status modifies the response to HIV-1 infection and to identify the major determinants of vitamin D status (UVB exposure, diet, pigmentation, and genetics). Vitamin D deficiency was observed in the majority of subjects in winter and in a proportion of individuals in summer, was highly correlated with UVB exposure, and was associated with greater HIV-1 replication in peripheral blood cells. High-dosage oral vitamin D3 supplementation attenuated HIV-1 replication, increased circulating leukocytes, and reversed winter-associated anemia. Vitamin D3 therefore presents as a low-cost supplementation to improve HIV-associated immunity.

Authors+Show Affiliations

Clinical Infectious Diseases Research Initiative, Institute of Infectious Disease and Molecular Medicine, University of Cape Town, Observatory 7925, South Africa;Centre for Evidence-based Health Care, Faculty of Medicine and Health Sciences, Stellenbosch University, Tygerberg 7505, South Africa;Clinical Infectious Diseases Research Initiative, Institute of Infectious Disease and Molecular Medicine, University of Cape Town, Observatory 7925, South Africa;Department of Geography, The Pennsylvania State University, University Park, PA 16802; Department of Anthropology, The Pennsylvania State University, University Park, PA 16802; Stellenbosch Institute for Advanced Studies, Stellenbosch 7600, South Africa;Clinical Infectious Diseases Research Initiative, Institute of Infectious Disease and Molecular Medicine, University of Cape Town, Observatory 7925, South Africa; The Francis Crick Institute, Mill Hill Laboratory, London NW7 1AA, United Kingdom; Department of Medicine, Imperial College London, London W2 1PG, United Kingdom.Department of Anthropology, The Pennsylvania State University, University Park, PA 16802; Stellenbosch Institute for Advanced Studies, Stellenbosch 7600, South Africa; ngj2@psu.edu.

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

26080414

Citation

Coussens, Anna K., et al. "High-dose Vitamin D3 Reduces Deficiency Caused By Low UVB Exposure and Limits HIV-1 Replication in Urban Southern Africans." Proceedings of the National Academy of Sciences of the United States of America, vol. 112, no. 26, 2015, pp. 8052-7.
Coussens AK, Naude CE, Goliath R, et al. High-dose vitamin D3 reduces deficiency caused by low UVB exposure and limits HIV-1 replication in urban Southern Africans. Proc Natl Acad Sci USA. 2015;112(26):8052-7.
Coussens, A. K., Naude, C. E., Goliath, R., Chaplin, G., Wilkinson, R. J., & Jablonski, N. G. (2015). High-dose vitamin D3 reduces deficiency caused by low UVB exposure and limits HIV-1 replication in urban Southern Africans. Proceedings of the National Academy of Sciences of the United States of America, 112(26), pp. 8052-7. doi:10.1073/pnas.1500909112.
Coussens AK, et al. High-dose Vitamin D3 Reduces Deficiency Caused By Low UVB Exposure and Limits HIV-1 Replication in Urban Southern Africans. Proc Natl Acad Sci USA. 2015 Jun 30;112(26):8052-7. PubMed PMID: 26080414.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - High-dose vitamin D3 reduces deficiency caused by low UVB exposure and limits HIV-1 replication in urban Southern Africans. AU - Coussens,Anna K, AU - Naude,Celeste E, AU - Goliath,Rene, AU - Chaplin,George, AU - Wilkinson,Robert J, AU - Jablonski,Nina G, Y1 - 2015/06/15/ PY - 2015/6/17/entrez PY - 2015/6/17/pubmed PY - 2015/11/18/medline KW - infectious disease KW - nutrition KW - pigmentation KW - polymorphism KW - seasonal variation SP - 8052 EP - 7 JF - Proceedings of the National Academy of Sciences of the United States of America JO - Proc. Natl. Acad. Sci. U.S.A. VL - 112 IS - 26 N2 - Cape Town, South Africa, has a seasonal pattern of UVB radiation and a predominantly dark-skinned urban population who suffer high HIV-1 prevalence. This coexistent environmental and phenotypic scenario puts residents at risk for vitamin D deficiency, which may potentiate HIV-1 disease progression. We conducted a longitudinal study in two ethnically distinct groups of healthy young adults in Cape Town, supplemented with vitamin D3 in winter, to determine whether vitamin D status modifies the response to HIV-1 infection and to identify the major determinants of vitamin D status (UVB exposure, diet, pigmentation, and genetics). Vitamin D deficiency was observed in the majority of subjects in winter and in a proportion of individuals in summer, was highly correlated with UVB exposure, and was associated with greater HIV-1 replication in peripheral blood cells. High-dosage oral vitamin D3 supplementation attenuated HIV-1 replication, increased circulating leukocytes, and reversed winter-associated anemia. Vitamin D3 therefore presents as a low-cost supplementation to improve HIV-associated immunity. SN - 1091-6490 UR - https://www.unboundmedicine.com/medline/citation/26080414/full_citation L2 - http://www.pnas.org/cgi/pmidlookup?view=long&pmid=26080414 DB - PRIME DP - Unbound Medicine ER -