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Plasma carotenoids and breast cancer risk in the Cancer Prevention Study II Nutrition Cohort.

Abstract

PURPOSE

Several circulating carotenoids have been inversely associated with postmenopausal breast cancer risk in large cohort studies and a pooled analysis. Whether associations differ by tumor or participant characteristics remains unclear. We investigated the associations of plasma carotenoids with postmenopausal breast cancer risk overall and by estrogen receptor (ER) status, tumor stage, smoking status, and body mass index, in a case-control study nested in the Cancer Prevention Study II Nutrition Cohort.

METHODS

A total of 496 invasive breast cancer cases diagnosed between blood draw in 1998-2001 and June 30, 2007 and matched 1:1 with controls on race, birth date, and blood draw date were included. Multivariable-adjusted conditional and unconditional logistic regression models were used to calculate odds ratios (ORs) and 95% confidence intervals (CIs).

RESULTS

Plasma α-carotene above the lowest quartile was associated with significant 40-43% lower risk of invasive breast cancer risk (fourth vs. first quartile OR 0.60, 95% CI 0.41-0.87, P-trend = 0.037) after adjustment for multiple covariates. This inverse association was strengthened after further adjustment for other plasma carotenoids and total fruit and vegetable intake (fourth vs. first quartile OR 0.50, 95% CI 0.29-0.85, P-trend = 0.041). Other plasma carotenoids or total carotenoids were not associated with breast cancer risk. The inverse association of α-carotene with breast cancer remained for ER+, but not for ER- tumors, although test for heterogeneity was not statistically significant (P-heterogeneity = 0.49).

CONCLUSIONS

These results suggest that higher plasma α-carotene is associated with lower risk of invasive breast cancer.

Links

  • Publisher Full Text
  • Authors+Show Affiliations

    ,

    Epidemiology Research Program, American Cancer Society, 250 Williams St NW, Atlanta, GA, 30303, USA, ying.wang@cancer.org.

    , , , ,

    Source

    Cancer causes & control : CCC 26:9 2015 Sep pg 1233-44

    MeSH

    Aged
    Body Mass Index
    Breast
    Breast Neoplasms
    Carotenoids
    Case-Control Studies
    Cohort Studies
    Diet
    Female
    Fruit
    Humans
    Middle Aged
    Neoplasm Staging
    Nutritional Status
    Receptors, Estrogen
    Risk
    Smoking
    Vegetables

    Pub Type(s)

    Journal Article
    Research Support, N.I.H., Extramural
    Research Support, U.S. Gov't, P.H.S.

    Language

    eng

    PubMed ID

    26081425

    Citation

    Wang, Ying, et al. "Plasma Carotenoids and Breast Cancer Risk in the Cancer Prevention Study II Nutrition Cohort." Cancer Causes & Control : CCC, vol. 26, no. 9, 2015, pp. 1233-44.
    Wang Y, Gapstur SM, Gaudet MM, et al. Plasma carotenoids and breast cancer risk in the Cancer Prevention Study II Nutrition Cohort. Cancer Causes Control. 2015;26(9):1233-44.
    Wang, Y., Gapstur, S. M., Gaudet, M. M., Furtado, J. D., Campos, H., & McCullough, M. L. (2015). Plasma carotenoids and breast cancer risk in the Cancer Prevention Study II Nutrition Cohort. Cancer Causes & Control : CCC, 26(9), pp. 1233-44. doi:10.1007/s10552-015-0614-4.
    Wang Y, et al. Plasma Carotenoids and Breast Cancer Risk in the Cancer Prevention Study II Nutrition Cohort. Cancer Causes Control. 2015;26(9):1233-44. PubMed PMID: 26081425.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Plasma carotenoids and breast cancer risk in the Cancer Prevention Study II Nutrition Cohort. AU - Wang,Ying, AU - Gapstur,Susan M, AU - Gaudet,Mia M, AU - Furtado,Jeremy D, AU - Campos,Hannia, AU - McCullough,Marjorie L, Y1 - 2015/06/17/ PY - 2014/12/09/received PY - 2015/06/06/accepted PY - 2015/6/18/entrez PY - 2015/6/18/pubmed PY - 2016/4/14/medline SP - 1233 EP - 44 JF - Cancer causes & control : CCC JO - Cancer Causes Control VL - 26 IS - 9 N2 - PURPOSE: Several circulating carotenoids have been inversely associated with postmenopausal breast cancer risk in large cohort studies and a pooled analysis. Whether associations differ by tumor or participant characteristics remains unclear. We investigated the associations of plasma carotenoids with postmenopausal breast cancer risk overall and by estrogen receptor (ER) status, tumor stage, smoking status, and body mass index, in a case-control study nested in the Cancer Prevention Study II Nutrition Cohort. METHODS: A total of 496 invasive breast cancer cases diagnosed between blood draw in 1998-2001 and June 30, 2007 and matched 1:1 with controls on race, birth date, and blood draw date were included. Multivariable-adjusted conditional and unconditional logistic regression models were used to calculate odds ratios (ORs) and 95% confidence intervals (CIs). RESULTS: Plasma α-carotene above the lowest quartile was associated with significant 40-43% lower risk of invasive breast cancer risk (fourth vs. first quartile OR 0.60, 95% CI 0.41-0.87, P-trend = 0.037) after adjustment for multiple covariates. This inverse association was strengthened after further adjustment for other plasma carotenoids and total fruit and vegetable intake (fourth vs. first quartile OR 0.50, 95% CI 0.29-0.85, P-trend = 0.041). Other plasma carotenoids or total carotenoids were not associated with breast cancer risk. The inverse association of α-carotene with breast cancer remained for ER+, but not for ER- tumors, although test for heterogeneity was not statistically significant (P-heterogeneity = 0.49). CONCLUSIONS: These results suggest that higher plasma α-carotene is associated with lower risk of invasive breast cancer. SN - 1573-7225 UR - https://www.unboundmedicine.com/medline/citation/26081425/full_citation L2 - https://doi.org/10.1007/s10552-015-0614-4 DB - PRIME DP - Unbound Medicine ER -