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NO-Rich Diet for Lifestyle-Related Diseases.

Abstract

Decreased nitric oxide (NO) availability due to obesity and endothelial dysfunction might be causally related to the development of lifestyle-related diseases such as insulin resistance, ischemic heart disease, and hypertension. In such situations, instead of impaired NO synthase (NOS)-dependent NO generation, the entero-salivary nitrate-nitrite-NO pathway might serve as a backup system for NO generation by transmitting NO activities in the various molecular forms including NO and protein S-nitrosothiols. Recently accumulated evidence has demonstrated that dietary intake of fruits and vegetables rich in nitrate/nitrite is an inexpensive and easily-practicable way to prevent insulin resistance and vascular endothelial dysfunction by increasing the NO availability; a NO-rich diet may also prevent other lifestyle-related diseases, including osteoporosis, chronic obstructive pulmonary disease (COPD), and cancer. This review provides an overview of our current knowledge of NO generation through the entero-salivary pathway and discusses its safety and preventive effects on lifestyle-related diseases.

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  • Authors+Show Affiliations

    ,

    Division of Pathophysiology, Department of Clinical Dietetics and Human Nutrition, Faculty of Pharmaceutical Science, Josai University, Saitama 350-0295, Japan. junkoba@josai.ac.jp.

    ,

    Division of Pathophysiology, Department of Clinical Dietetics and Human Nutrition, Faculty of Pharmaceutical Science, Josai University, Saitama 350-0295, Japan. kazuo@josai.ac.jp.

    Division of Pathophysiology, Department of Clinical Dietetics and Human Nutrition, Faculty of Pharmaceutical Science, Josai University, Saitama 350-0295, Japan. mrhiro@josai.ac.jp.

    Source

    Nutrients 7:6 2015 Jun 17 pg 4911-37

    MeSH

    Animals
    Biological Availability
    Chronic Disease
    Diet
    Disease Models, Animal
    Fruit
    Humans
    Life Style
    Nitrates
    Nitric Oxide
    Nitrites
    S-Nitrosothiols
    Vegetables

    Pub Type(s)

    Journal Article
    Research Support, Non-U.S. Gov't
    Review

    Language

    eng

    PubMed ID

    26091235

    Citation

    Kobayashi, Jun, et al. "NO-Rich Diet for Lifestyle-Related Diseases." Nutrients, vol. 7, no. 6, 2015, pp. 4911-37.
    Kobayashi J, Ohtake K, Uchida H. NO-Rich Diet for Lifestyle-Related Diseases. Nutrients. 2015;7(6):4911-37.
    Kobayashi, J., Ohtake, K., & Uchida, H. (2015). NO-Rich Diet for Lifestyle-Related Diseases. Nutrients, 7(6), pp. 4911-37. doi:10.3390/nu7064911.
    Kobayashi J, Ohtake K, Uchida H. NO-Rich Diet for Lifestyle-Related Diseases. Nutrients. 2015 Jun 17;7(6):4911-37. PubMed PMID: 26091235.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - NO-Rich Diet for Lifestyle-Related Diseases. AU - Kobayashi,Jun, AU - Ohtake,Kazuo, AU - Uchida,Hiroyuki, Y1 - 2015/06/17/ PY - 2015/04/02/received PY - 2015/06/08/revised PY - 2015/06/09/accepted PY - 2015/6/20/entrez PY - 2015/6/20/pubmed PY - 2016/5/4/medline KW - cancer KW - chronic obstructive pulmonary disease (COPD) KW - insulin resistance KW - ischemia/reperfusion injury KW - lifestyle-related disease KW - nitrate KW - nitric oxide (NO) KW - nitrite KW - osteoporosis SP - 4911 EP - 37 JF - Nutrients JO - Nutrients VL - 7 IS - 6 N2 - Decreased nitric oxide (NO) availability due to obesity and endothelial dysfunction might be causally related to the development of lifestyle-related diseases such as insulin resistance, ischemic heart disease, and hypertension. In such situations, instead of impaired NO synthase (NOS)-dependent NO generation, the entero-salivary nitrate-nitrite-NO pathway might serve as a backup system for NO generation by transmitting NO activities in the various molecular forms including NO and protein S-nitrosothiols. Recently accumulated evidence has demonstrated that dietary intake of fruits and vegetables rich in nitrate/nitrite is an inexpensive and easily-practicable way to prevent insulin resistance and vascular endothelial dysfunction by increasing the NO availability; a NO-rich diet may also prevent other lifestyle-related diseases, including osteoporosis, chronic obstructive pulmonary disease (COPD), and cancer. This review provides an overview of our current knowledge of NO generation through the entero-salivary pathway and discusses its safety and preventive effects on lifestyle-related diseases. SN - 2072-6643 UR - https://www.unboundmedicine.com/medline/citation/26091235/full_citation L2 - http://www.mdpi.com/resolver?pii=nu7064911 DB - PRIME DP - Unbound Medicine ER -