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Vitamin D deficiency is associated with increased risk of Alzheimer's disease and dementia: evidence from meta-analysis.

Abstract

BACKGROUND

In recent years, the associations between vitamin D status and Alzheimer's disease (AD) and dementia have gained increasing interests. The present meta-analysis was designed to estimate the association between vitamin D deficiency and risk of developing AD and dementia.

METHODS

A literature search conducted until February 2015 identified 10 study populations, which were included in the meta-analysis. Pooled risk ratios (RRs) and 95% confidence interval (CI) were calculated with a random-effect model using Stata software package.

RESULTS

Results of our meta-analysis showed that subjects with deficient vitamin D status (25(OH)D level < 50 nmol/L) were at increased risk of developing AD by 21% compared with those possessing 25(OH)D level > 50 nmol/L. Similar analysis also found a significantly increased dementia risk in vitamin D deficient subjects. There is no evidence for significant heterogeneity among the included studies.

CONCLUSION

Available data indicates that lower vitamin D status may be associated with increased risk of developing AD and dementia. More studies are needed to further confirm the associations and to evaluate the beneficial effects of vitamin D supplementation in preventing AD and dementia.

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  • Authors+Show Affiliations

    ,

    Shandong Provincial Research Center for Bioinformatic Engineering and Technique, School of Life Sciences, Shandong University of Technology, Zibo, 255049, P. R. China.

    Shandong Provincial Research Center for Bioinformatic Engineering and Technique, School of Life Sciences, Shandong University of Technology, Zibo, 255049, P. R. China. jhf@sdut.edu.cn.

    Source

    Nutrition journal 14: 2015 pg 76

    MeSH

    Alzheimer Disease
    Dementia
    Dietary Supplements
    Humans
    Risk Factors
    Vitamin D
    Vitamin D Deficiency

    Pub Type(s)

    Journal Article
    Meta-Analysis
    Research Support, Non-U.S. Gov't

    Language

    eng

    PubMed ID

    26231781

    Citation

    TY - JOUR T1 - Vitamin D deficiency is associated with increased risk of Alzheimer's disease and dementia: evidence from meta-analysis. AU - Shen,Liang, AU - Ji,Hong-Fang, Y1 - 2015/08/01/ PY - 2015/5/26/received PY - 2015/7/27/accepted PY - 2015/8/1/aheadofprint PY - 2015/8/2/entrez PY - 2015/8/2/pubmed PY - 2016/6/9/medline SP - 76 EP - 76 JF - Nutrition journal JO - Nutr J VL - 14 N2 - BACKGROUND: In recent years, the associations between vitamin D status and Alzheimer's disease (AD) and dementia have gained increasing interests. The present meta-analysis was designed to estimate the association between vitamin D deficiency and risk of developing AD and dementia. METHODS: A literature search conducted until February 2015 identified 10 study populations, which were included in the meta-analysis. Pooled risk ratios (RRs) and 95% confidence interval (CI) were calculated with a random-effect model using Stata software package. RESULTS: Results of our meta-analysis showed that subjects with deficient vitamin D status (25(OH)D level < 50 nmol/L) were at increased risk of developing AD by 21% compared with those possessing 25(OH)D level > 50 nmol/L. Similar analysis also found a significantly increased dementia risk in vitamin D deficient subjects. There is no evidence for significant heterogeneity among the included studies. CONCLUSION: Available data indicates that lower vitamin D status may be associated with increased risk of developing AD and dementia. More studies are needed to further confirm the associations and to evaluate the beneficial effects of vitamin D supplementation in preventing AD and dementia. SN - 1475-2891 UR - https://www.unboundmedicine.com/medline/citation/26231781/full_citation L2 - http://nutritionj.biomedcentral.com/articles/10.1186/s12937-015-0063-7 ER -