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Vitamin D supplementation to patients with frequent respiratory tract infections: a post hoc analysis of a randomized and placebo-controlled trial.
BMC Res Notes 2015; 8:391BR

Abstract

BACKGROUND

Vitamin D is considered to be important for a healthy immune system. The aim of this study was to test the hypothesis that vitamin D supplementation reduces number of respiratory tract infections (RTIs) and prolong the time to the first RTI in adult patients with frequent RTIs.

METHODS

We performed a post hoc analysis of a randomized, placebo-controlled and double-blinded study, where adult patients with a high burden of RTIs were randomized to placebo or vitamin D (4000 IE/day for 1 year, n = 124 in the per protocol cohort presented here).

RESULTS

Vitamin D supplementation increased the probability to stay free of RTI during the study year (RR 0.64, 95% CI 0.43-0.94). Further, the total number of RTIs was also reduced in the vitamin D-group (86 RTIs) versus placebo (120 RTIs; p = 0.05). Finally, the time to the first RTI was significantly extended in the vitamin D-group (HR 1.68, 95% CI 1.03-2.68, p = 0.0376).

CONCLUSION

Vitamin D supplementation was found to significantly increase the probability of staying infection free during the study period. This finding further supports the notion that vitamin D-status should be monitored in adult patients with frequent RTIs and suggests that selected patients with vitamin D deficiency are supplemented. This could be a safe and cheap way to reduce RTIs and improve health in this vulnerable patient population. The original trial was registered at http://www.clinicaltrials.gov (NCT01131858).

Authors+Show Affiliations

Division of Clinical Microbiology, Department of Laboratory Medicine, Karolinska Institutet and Karolinska University Hospital Huddinge, 141 86, Stockholm, Sweden. peter.bergman@ki.se.Division of Clincal Immunology, Karolinska Institutet and Karolinska University Hospital Huddinge, 141 86, Stockholm, Sweden. anna-carin.norlin@karolinska.se.Infectious Disease Clinic, Karolinska University Hospital, 141 86, Stockholm, Sweden. susanne.hansen@karolinska.se.Division of Clinical Microbiology, Department of Laboratory Medicine, Karolinska Institutet and Karolinska University Hospital Huddinge, 141 86, Stockholm, Sweden. linda.bjorkhem-bergman@ki.se.

Pub Type(s)

Journal Article
Randomized Controlled Trial
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

26319134

Citation

Bergman, Peter, et al. "Vitamin D Supplementation to Patients With Frequent Respiratory Tract Infections: a Post Hoc Analysis of a Randomized and Placebo-controlled Trial." BMC Research Notes, vol. 8, 2015, p. 391.
Bergman P, Norlin AC, Hansen S, et al. Vitamin D supplementation to patients with frequent respiratory tract infections: a post hoc analysis of a randomized and placebo-controlled trial. BMC Res Notes. 2015;8:391.
Bergman, P., Norlin, A. C., Hansen, S., & Björkhem-Bergman, L. (2015). Vitamin D supplementation to patients with frequent respiratory tract infections: a post hoc analysis of a randomized and placebo-controlled trial. BMC Research Notes, 8, p. 391. doi:10.1186/s13104-015-1378-3.
Bergman P, et al. Vitamin D Supplementation to Patients With Frequent Respiratory Tract Infections: a Post Hoc Analysis of a Randomized and Placebo-controlled Trial. BMC Res Notes. 2015 Aug 30;8:391. PubMed PMID: 26319134.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Vitamin D supplementation to patients with frequent respiratory tract infections: a post hoc analysis of a randomized and placebo-controlled trial. AU - Bergman,Peter, AU - Norlin,Anna-Carin, AU - Hansen,Susanne, AU - Björkhem-Bergman,Linda, Y1 - 2015/08/30/ PY - 2015/04/01/received PY - 2015/08/24/accepted PY - 2015/8/31/entrez PY - 2015/9/1/pubmed PY - 2016/6/9/medline SP - 391 EP - 391 JF - BMC research notes JO - BMC Res Notes VL - 8 N2 - BACKGROUND: Vitamin D is considered to be important for a healthy immune system. The aim of this study was to test the hypothesis that vitamin D supplementation reduces number of respiratory tract infections (RTIs) and prolong the time to the first RTI in adult patients with frequent RTIs. METHODS: We performed a post hoc analysis of a randomized, placebo-controlled and double-blinded study, where adult patients with a high burden of RTIs were randomized to placebo or vitamin D (4000 IE/day for 1 year, n = 124 in the per protocol cohort presented here). RESULTS: Vitamin D supplementation increased the probability to stay free of RTI during the study year (RR 0.64, 95% CI 0.43-0.94). Further, the total number of RTIs was also reduced in the vitamin D-group (86 RTIs) versus placebo (120 RTIs; p = 0.05). Finally, the time to the first RTI was significantly extended in the vitamin D-group (HR 1.68, 95% CI 1.03-2.68, p = 0.0376). CONCLUSION: Vitamin D supplementation was found to significantly increase the probability of staying infection free during the study period. This finding further supports the notion that vitamin D-status should be monitored in adult patients with frequent RTIs and suggests that selected patients with vitamin D deficiency are supplemented. This could be a safe and cheap way to reduce RTIs and improve health in this vulnerable patient population. The original trial was registered at http://www.clinicaltrials.gov (NCT01131858). SN - 1756-0500 UR - https://www.unboundmedicine.com/medline/citation/26319134/full_citation L2 - https://bmcresnotes.biomedcentral.com/articles/10.1186/s13104-015-1378-3 DB - PRIME DP - Unbound Medicine ER -