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Magnesium and type 2 diabetes.

Abstract

Type 2 diabetes is frequently associated with both extracellular and intracellular magnesium (Mg) deficits. A chronic latent Mg deficit or an overt clinical hypomagnesemia is common in patients with type 2 diabetes, especially in those with poorly controlled glycemic profiles. Insulin and glucose are important regulators of Mg metabolism. Intracellular Mg plays a key role in regulating insulin action, insulin-mediated-glucose-uptake and vascular tone. Reduced intracellular Mg concentrations result in a defective tyrosine-kinase activity, postreceptorial impairment in insulin action and worsening of insulin resistance in diabetic patients. A low Mg intake and an increased Mg urinary loss appear the most important mechanisms that may favor Mg depletion in patients with type 2 diabetes. Low dietary Mg intake has been related to the development of type 2 diabetes and metabolic syndrome. Benefits of Mg supplementation on metabolic profiles in diabetic patients have been found in most, but not all clinical studies and larger prospective studies are needed to support the potential role of dietary Mg supplementation as a possible public health strategy in diabetes risk. The aim of this review is to revise current evidence on the mechanisms of Mg deficiency in diabetes and on the possible role of Mg supplementation in the prevention and management of the disease.

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    ,

    Mario Barbagallo, Ligia J Dominguez, Geriatric Unit, Department of Internal Medicine and Medical Specialties, University of Palermo, 90127 Palermo, Italy.

    Mario Barbagallo, Ligia J Dominguez, Geriatric Unit, Department of Internal Medicine and Medical Specialties, University of Palermo, 90127 Palermo, Italy.

    Source

    World journal of diabetes 6:10 2015 Aug 25 pg 1152-7

    Pub Type(s)

    Journal Article
    Review

    Language

    eng

    PubMed ID

    26322160

    Citation

    Barbagallo, Mario, and Ligia J. Dominguez. "Magnesium and Type 2 Diabetes." World Journal of Diabetes, vol. 6, no. 10, 2015, pp. 1152-7.
    Barbagallo M, Dominguez LJ. Magnesium and type 2 diabetes. World J Diabetes. 2015;6(10):1152-7.
    Barbagallo, M., & Dominguez, L. J. (2015). Magnesium and type 2 diabetes. World Journal of Diabetes, 6(10), pp. 1152-7. doi:10.4239/wjd.v6.i10.1152.
    Barbagallo M, Dominguez LJ. Magnesium and Type 2 Diabetes. World J Diabetes. 2015 Aug 25;6(10):1152-7. PubMed PMID: 26322160.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Magnesium and type 2 diabetes. AU - Barbagallo,Mario, AU - Dominguez,Ligia J, PY - 2015/04/15/received PY - 2015/06/29/revised PY - 2015/08/16/accepted PY - 2015/9/1/entrez PY - 2015/9/1/pubmed PY - 2015/9/1/medline KW - Aging KW - Endothelium KW - Hypertension KW - Inflammation KW - Insulin resistance KW - Magnesium KW - Metabolic syndrome KW - Type 2 diabetes SP - 1152 EP - 7 JF - World journal of diabetes JO - World J Diabetes VL - 6 IS - 10 N2 - Type 2 diabetes is frequently associated with both extracellular and intracellular magnesium (Mg) deficits. A chronic latent Mg deficit or an overt clinical hypomagnesemia is common in patients with type 2 diabetes, especially in those with poorly controlled glycemic profiles. Insulin and glucose are important regulators of Mg metabolism. Intracellular Mg plays a key role in regulating insulin action, insulin-mediated-glucose-uptake and vascular tone. Reduced intracellular Mg concentrations result in a defective tyrosine-kinase activity, postreceptorial impairment in insulin action and worsening of insulin resistance in diabetic patients. A low Mg intake and an increased Mg urinary loss appear the most important mechanisms that may favor Mg depletion in patients with type 2 diabetes. Low dietary Mg intake has been related to the development of type 2 diabetes and metabolic syndrome. Benefits of Mg supplementation on metabolic profiles in diabetic patients have been found in most, but not all clinical studies and larger prospective studies are needed to support the potential role of dietary Mg supplementation as a possible public health strategy in diabetes risk. The aim of this review is to revise current evidence on the mechanisms of Mg deficiency in diabetes and on the possible role of Mg supplementation in the prevention and management of the disease. SN - 1948-9358 UR - https://www.unboundmedicine.com/medline/citation/26322160/full_citation L2 - http://www.wjgnet.com/1948-9358/full/v6/i10/1152.htm DB - PRIME DP - Unbound Medicine ER -